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C57BL/6JGpt-Uoxem3Cd3501/Gpt

Mouse Model: Uox-KO
Strain Number: T011801

Knockout (KO)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Uoxem3Cd3501/Gpt
Strain Number: T011801
Official Symbol: Uox
Strain Strategy: T011801.Uox-KO Strategy-EN.pdfT011801.Uox-KO strain info.pdf
Official Full Name: urate oxidase
Also Known As: AI663847
NCBI Number: 22262
MGI Number: 98907
Chromosome: 3
Deletion (size): -3501bp
Research Areas: Disease Models,Metabolic Disease,hyperuricemia model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications. J Cardiovasc Transl Res (2024)2. Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy. Pharmaceutics (2024)3. Spatiotemporal landscape of kidney in a mouse model of hyperuricemia at single‐cell level. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2025)4. Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization. Journal of inflammation research (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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