C57BL/6JGpt-Mlklem1Cd1679/Gpt
Mouse Model: Mlkl-KO
Strain Number: T002470
Knockout (KO)
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- Quantity: - +
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Mlklem1Cd1679/Gpt |
| Strain Number: | T002470 |
| Official Symbol: | Mlkl |
| Strain Strategy: | T002470. Mlkl Cas9-KO Strategy-EN.pdf |
| Official Full Name: | mixed lineage kinase domain-like |
| Also Known As: | 9130019I15Rik |
| NCBI Number: | 74568 |
| MGI Number: | 1921818 |
| Chromosome: | 8 |
| Deletion (size): | -1679bp |
| Research Areas: | Metabolic research,Protein metabolism,homeostasis/metabolism,immune system,Physiological system,hematopoietic system,Cell biology,Cell death,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T002470.Mlkl Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. MLKL is involved in the regulation of skin wound healing and interplay between macrophages and myofibroblasts in mice. Sci Rep (2025)2. Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1. Nat Commun (2024) |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.