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C57BL/6JGpt-Sting1em10Cd12452/Gpt

Sting1-KO|Strain NO.T012747

Knockout (KO)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Sting1em10Cd12452/Gpt
Strain Number: T012747
Official Symbol: Sting1
Strain Strategy: T012747.Sting1 Cas9-KO Strategy-EN.pdf
Official Full Name: stimulator of interferon response cGAMP interactor 1
Also Known As: 2610307O08Rik,ERIS,MPYS,Mita,STING,STING-beta,Tmem173
NCBI Number: 72512
MGI Number: 1919762
Chromosome: 18
Deletion (size): -12452bp
Research Areas: Metabolic research,homeostasis/metabolism,Developmental Biology,mortality/aging,immune system,Physiological system,integument,respiratory system,digestive/alimentary system,hematopoietic system,Cell biology,Mitochondrial research,cellular,Cytoplasmic vesicle,endoplasmic reticulum,endosome,Golgi apparatus,cell nucleus,cytomembrane,Organelles membrane,Molecular biology,DNA transcription
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T012747.Sting1 Genotyping Protocol(KO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses2. Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment3. Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway4. Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity5. Flavonoid Derivative DMXAA Attenuates Cisplatin-induced Acute Kidney Injury Independent of STING Signaling6. STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury7. The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation8. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages9. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis