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C57BL/6JGpt-Sting1em10Cd12452/Gpt

Sting1-KO|Strain NO.T012747

Knockout (KO)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Sting1em10Cd12452/Gpt
Strain Number: T012747
Official Symbol: Sting1
Strain Strategy: T012747.Sting1 Cas9-KO Strategy-EN.pdfT012747.Sting1-KO strain info.pdf
Official Full Name: stimulator of interferon response cGAMP interactor 1
Also Known As: 2610307O08Rik,ERIS,MPYS,Mita,STING,STING-beta,Tmem173
NCBI Number: 72512
MGI Number: 1919762
Chromosome: 18
Deletion (size): -12452bp
Research Areas: Metabolic research,homeostasis/metabolism,Developmental Biology,mortality/aging,immune system,Physiological system,integument,respiratory system,digestive/alimentary system,hematopoietic system,Cell biology,Mitochondrial research,cellular,Cytoplasmic vesicle,endoplasmic reticulum,endosome,Golgi apparatus,cell nucleus,cytomembrane,Organelles membrane,Molecular biology,DNA transcription
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T012747.Sting1 Genotyping Protocol(KO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses. Nat Commun (2022)2. Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment. Bioact Mater (2023)3. Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway. Research (2023)4. Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity. Nat Commun (2023)5. Flavonoid Derivative DMXAA Attenuates Cisplatin-induced Acute Kidney Injury Independent of STING Signaling. CLINICAL SCIENCE (2023)6. STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. Free Radic Biol Med (2023)7. The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation. Signal Transduct Target Ther (2023)8. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death Dis (2022)9. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis. Eur J Pharmacol (2022)10. A Frog Skin-Derived Peptide Targeting SCD1 Exerts Radioprotective Effects Against Skin Injury by Inhibiting STING-Mediated Inflammation. Adv Sci (2024)11. Effect of Regulation of Chemerin/Chemokine-like Receptor 1/Stimulator of Interferon Genes Pathway on Astrocyte Recruitment to Abeta Plaques. Int J Mol Sci (2024)12. Revamping anti-cGAS-STING therapy via an injectable thermo-responsive supramolecular hydrogel for pathological retinal Angiogenesis. Asian Journal of Pharmaceutical Sciences (2024)13. The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3‐Mediated Pyroptosis. J Cachexia Sarcopenia Muscle (2024)14. STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia. Cell Death Dis (2024)15. Degradation of PARP1 by MARCHF3 in tumor cells triggers cCAS-STING activation in dendritic cells to regulate antitumor immunity in hepatocellular …. J Immunother Cancer (2024)16. Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy. Cancer Cell (2025)17. Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder. Adv Sci (Weinh) (2025)