C57BL/6JGpt-Nfe2l1em1Cflox/Gpt
Nfe2l1-flox|Strain NO.T016349
Conditional knockout (cKO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Nfe2l1em1Cflox/Gpt |
| Strain Number: | T016349 |
| Official Symbol: | Nfe2l1 |
| Strain Strategy: | T016349.Nfe2l1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | nuclear factor, erythroid derived 2,-like 1 |
| Also Known As: | AA408798,AW212678,LCR-F1,Lcrf1,NRF1,TCF-11,TCF11 |
| NCBI Number: | 18023 |
| MGI Number: | 99421 |
| Chromosome: | 11 |
| Distance Between Two Loxps: | 6300bp |
| Research Areas: | Metabolic research,Developmental Biology,immune system,integument,Tumor research,DNA transcription,digestive/alimentary system,Protein metabolism,Glucose metabolism,liver/biliary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,cell differentiation,Cell biology,Molecular biology,cellular,embryo,growth/size/body,hematopoietic system,mortality/aging,Cell localization,Lipid Metabolism,endoplasmic reticulum,cell nucleus,DNA binding protein,Lipid binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T016349.Nfe2l1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation. Cell Reports (2024)2. NRF1 coordinates mitochondrial adaptations to dampen intracellular ROS and inflammatory responses during ischemia reperfusion. Cell death discovery (2025) |
| Gene Family: | Basic leucine zipper proteins |