C57BL/6JGpt-Atf4em1Cd2205/Gpt
Mouse Model: Atf4-KO
Strain Number: T002330
Knockout (KO)
- Product Type:
- Quantity: - +
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- Age:
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Atf4em1Cd2205/Gpt |
| Strain Number: | T002330 |
| Official Symbol: | Atf4 |
| Strain Strategy: | T002330. ATF4(Atf4） Cas9-KO Strategy-EN.pdf |
| Official Full Name: | activating transcription factor 4 |
| Also Known As: | Atf-4,C/ATF,CREB2,TAXREB67 |
| NCBI Number: | 11911 |
| MGI Number: | 88096 |
| Chromosome: | 15 |
| Deletion (size): | -2205bp |
| Research Areas: | Metabolic research,adipose tissue,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,vision/eye,Physiological system,integument,cardiovascular system,skeleton,craniofacial ,Muscle ,reproductive system,digestive/alimentary system,liver/biliary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell death,Cytoskeleton,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T002330.Atf4 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A‐mediated endothelial epigenetic alteration. The FASEB Journal (2021)2. miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research (2021)3. ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy. Life Sciences (2021) |
| Gene Family: | Basic leucine zipper proteins |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.