C57BL/6JGpt-Atf4em1Cd2205/Gpt
Atf4-KO|Strain NO.T002330
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Atf4em1Cd2205/Gpt |
| Strain Number: | T002330 |
| Official Symbol: | Atf4 |
| Strain Strategy: | T002330. ATF4(Atf4） Cas9-KO Strategy-EN.pdf |
| Official Full Name: | activating transcription factor 4 |
| Also Known As: | Atf-4,C/ATF,CREB2,TAXREB67 |
| NCBI Number: | 11911 |
| MGI Number: | 88096 |
| Chromosome: | 15 |
| Deletion (size): | -2205bp |
| Research Areas: | Metabolic research,adipose tissue,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,vision/eye,Physiological system,integument,cardiovascular system,skeleton,craniofacial ,Muscle ,reproductive system,digestive/alimentary system,liver/biliary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell death,Cytoskeleton,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T002330.Atf4 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Activating transcription factor 4 regulates angiogenesis under lipid overload via methionine adenosyltransferase 2A‐mediated endothelial epigenetic alteration2. miR-1283 Contributes to Endoplasmic Reticulum Stress in the Development of Hypertension Through the Activating Transcription Factor-4 (ATF4)/C/EBP-Homologous Protein (CHOP) Signaling Pathway3. ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy |
| Gene Family: | Basic leucine zipper proteins |