BALB/cJGpt

BALB/cJGpt|Strain NO.N000020

Inbred strain

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BASIC INFORMATION

Strain Name:	BALB/cJGpt
Strain Number:	N000020
Official Symbol:
Strain Strategy:	N000020.BALB_cJGpt strain info.pdf
Research Areas:	Inbred line
Strain Background:	[N000020] BALB/cJGpt
Modification Type:	Inbred strain
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice 2. The third generation anti-HER2 chimeric antigen receptor mouse T cells alone or together with anti-PD1 antibody inhibits the growth of mouse breast tumor cells expressing HER2 in vitro and in immune competent mice 3. CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK 4. Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer 5. Creatine promotes cancer metastasis through activation of Smad2/3 6. Iron Doped Carbon Dots based Nanohybrids as a Tetramodal Imaging Agent for Gene Delivery promotion and Photothermal-Chemodynamic Cancer Synergistic Theranostics 7. Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression 8. Polymer-directed supramolecular assembly of photosensitizers: Evocation of photothermal effect and highly efficient loading of disulfiram for chemo-phototherapy of cancer 9. PPARγ mediates the anti-epithelial-mesenchymal transition effects of FGF1ΔHBS in chronic kidney diseases via inhibition of TGF-β1/SMAD3 signaling 10. Transdermal delivery of heparin using low-frequency sonophoresis in combination with sponge spicules for venous thrombosis treatment 11. Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and Pcsk9 siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer 12. Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology 13. Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments 14. Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation 15. Magnetic Fields Affect Alcoholic Liver Disease by Liver Cell Oxidative Stress and Proliferation Regulation 16. Controlled intracellular aggregation of magnetic particles improves permeation and retention for magnetic hyperthermia promotion and immune activation 17. EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1 18. ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy 19. Stimuli-responsive heparin-drug conjugates co-assembled into stable nanomedicines for cancer therapy 20. Design of a novel chimeric peptide via dual blockade of CD47/SIRPalpha and PD-1/PD-L1 for cancer immunotherapy 21. Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging 22. LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2 23. FGF19-Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer 24. Glutathione-Exhausting Nanoprobes for NIR-II Fluorescence Imaging-Guided Surgery and Boosting Radiation Therapy Efficacy via Ferroptosis in Breast Cancer 25. Near-Infrared Persistent Luminescence Nanoprobe for Ultrasensitive Image-Guided Tumor Resection 26. Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease 27. Gastric Acid-Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora 28. The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma 29. Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway 30. Appendectomy Mitigates Coxsackievirus B3−Induced Viral Myocarditis 31. B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation 32. Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR 33. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer 34. PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype 35. Enhanced Chemo-Immunotherapy Strategy Utilizing Injectable Thermosensitive Hydrogel for The Treatment of Diffuse Peritoneal Metastasis in Advanced Colorectal Cancer 36. Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response 37. Long-term assessment of cutaneous inflammation and treatment using optical resolution photoacoustic microscopy 38. SARS-CoV-2 mRNA vaccine requires signal peptide to induce antibody responses 39. Engineered oncolytic bacteria HCS1 exerts high immune stimulation and safety profiles for cancer therapy 40. Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine 41. Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation 42. Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect 43. Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis 44. Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis 45. Decitabine/paclitaxel co-delivery systems modified with anti-PD-L1 antibodies mediate chemoimmunotherapy for Triple negative breast cancer 46. Dual‑directional effect of vinorelbine combined with cisplatin or fluorouracil on tumor growth and metastasis in metronomic chemotherapy in breast cancer 47. Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-kappaB-dependent cardiomyocyte pyroptosis 48. Nano-modulators with the function of disrupting mitochondrial Ca(2+) homeostasis and photothermal conversion for synergistic breast cancer therapy 49. PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer 50. Retinoic acid-inducible gene-1 knockdown induces immature properties in dendritic cells and prolongs the survival time of allograft mice 51. TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5 52. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism 53. MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning 54. BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation 55. LncRNA CHROMR/miR-27b-3p/MET axis promotes the proliferation, invasion and contributes to rituximab resistance in diffuse large B-cell lymphoma 56. Usenamine A triggers NLRP3 caspase-1 GSDMD-mediated pyroptosis in lung adenocarcinoma by targeting the DDX3X SQSTM1 axis 57. Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis 58. CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway 59. AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria 60. LncRNA CHROMR/miR-27b-3p/MET axis promotes the proliferation, invasion, and contributes to rituximab resistance in diffuse large B-cell lymphoma 61. A Free Amino Acid Diet Alleviates Colorectal Tumorigenesis through Modulating Gut Microbiota and Metabolites 62. Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma 63. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease 64. Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation 65. The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis 66. An induced mutation of ABC-transporter component VraF(K84E) contributes to vancomycin resistance and virulence in Staphylococcus aureus strain MW2 67. Biomimetic Hydrogel-Mediated Mechano-Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery 68. Fc-Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies 69. VISTA‐targeted antibody‐drug conjugates exhibit potent antitumor effects on malignant pleural mesothelioma 70. Protective effects of Bacillus amyloliquefaciens-derived nonapeptide in cyclophosphamide-induced immunosuppressed mice 71. Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma 72. The rheumatoid arthritis drug auranofin exerts potent anti-lymphoma effect by stimulating TXNRD-mediated ROS generation and inhibition of energy metabolism 73. TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors 74. Exposure to microcystin-LR promotes the progression of colitis-associated colorectal cancer by inducing barrier disruption and gut microbiota dysbiosis 75. A High Immune-Related Index with the Suppression of cGAS-STING Pathway is a Key Determinant to Herceptin Resistance in HER2+ Breast Cancer 76. (19)F MRI/CEUS Dual Imaging-Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple-Negative Breast Cancer 77. Immunogen characterization reveals an intrinsic hindrance in eliciting neutralizing antibodies against JN.1 variant 78. Role of TSP-1 and its receptor ITGB3 in the renal tubulointerstitial injury of focal segmental glomerulosclerosis 79. alpha-Lactalbumin mRNA-LNP Evokes an Anti-Tumor Effect Combined with Surgery in Triple-Negative Breast Cancer 80. Suppression of pathological neovascularization by anti-Flt1 peptide functionalized DNA tetrahedron 81. Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery 82. Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis 83. Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE(2) production 84. Trim21-mediated CCT2 ubiquitination suppresses malignant progression and promotes CD4(+)T cell activation in breast cancer 85. Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma 86. Preclinical Efficacy of Cap-Dependent and Independent mRNA Vaccines against Bovine Viral Diarrhea Virus-1 87. GelMA loaded with platelet lysate promotes skin regeneration and angiogenesis in pressure ulcers by activating STAT3 88. Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis 89. Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer 90. 19F MRI/CEUS Dual Imaging‐Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple‐Negative Breast Cancer 91. The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells 92. Microcystin-LR Regulates Interaction between Tumor Cells and Macrophages via the IRE1α/XBP1 Signaling Pathway to Promote the Progression of Colorectal Cancer 93. Natural agents derived Pickering emulsion enabled by silica nanoparticles with enhanced antibacterial activity against drug-resistant bacteria 94. Apoptotic vesicles (apoVs) derived from fibroblast-converted hepatocyte-like cells effectively ameliorate liver fibrosis 95. Nanobody-Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING-Mediated Anti-Tumor Immunity 96. Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2 97. Local administration of mRNA encoding cytokine cocktail confers potent anti-tumor immunity 98. Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy 99. FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity 100. Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I 101. Photothermal Catalytic Reduction and Bone Tissue Engineering Towards a Three-in-One Therapy Strategy for Osteosarcoma 102. Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells 103. Enhanced tumor targeting and penetration of fluorophores via iRGD peptide conjugation: a strategy for the precision targeting of lung cancer 104. Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy 105. Multiplex antimicrobial activities of the self-assembled amphiphilic polypeptide β nanofiber KF-5 against vaginal pathogens 106. The protective effect and immunomodulatory ability of orally administrated Lacticaseibacillus rhamnosus GG against Mycoplasma pneumoniae infection in BALB/c mice 107. Dynamic transition of Tregs to cytotoxic phenotype amid systemic inflammation in Graves' ophthalmopathy 108. Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles 109. Egg White Diet Induces Severe Allergic Enteritis in an Animal Model Driven by Caspase-3 and Gasdermin C-Mediated Mucosal Alarmin Secretion 110. Dyna-vivo-seq unveils cellular RNA dynamics during acute kidney injury via in vivo metabolic RNA labeling-based scRNA-seq 111. Social isolation promotes tumor immune evasion via β2-adrenergic receptor 112. TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation 113. A protocol for high-throughput screening for small chemicals promoting macrophage-mediated tumor cell phagocytosis in mice 114. OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment 115. Signature of Immune-Related Metabolic Genes Predicts the Prognosis of Hepatocellular Carcinoma 116. Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis 117. Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity 118. MTHFD1 Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the PI3K‐AKT–mTOR Signaling Pathway 119. NOP10 predicts poor prognosis and promotes pancreatic cancer progression 120. Smart Persistent Luminescence Imaging for Early Diagnosis of Drug-Induced Liver Injury 121. Ruthenium (II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy 122. Defining the features and structure of neutralizing antibody targeting the silent face of the SARS‐CoV‐2 spike N‐terminal domain 123. A cascade X-ray energy converting approach toward radio-afterglow cancer theranostics 124. Heart ultrasound and biomechanical evaluation of radiation‐induced heart toxicity using transthoracic echocardiogram (TTE) and dynamic mechanical analysis (DMA)125. Radiation induced liver injury (RILI) evaluation using longitudinal computed tomography (CT) in image‐guided precision murine radiotherapy 126. Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis 127. ZNF655 involved in the progression of multiple myeloma via the activation of AKT 128. Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target 129. Imbalance of oral microbiome homeostasis: the relationship between microbiota and the occurrence of dental caries 130. Preclinical evaluation of 68Ga‐labeled peptides for targeting CD44 imaging 131. House dust mite induced mucosal barrier dysfunction and type 2 inflammatory responses via the MAPK/AP-1/IL-24 Signaling pathway in allergic rhinitis 132. A Humanized Anti-B7H3× 4-1BB Bispecific Antibody Exerts Potent Antitumor Effects through the Activation of Innate and Adaptive Immunity 133. SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway 134. A pH-responsive magnetic-controlled nanocomposite for precise and efficient vancomycin delivery in treating prosthetic joint infections 135. Synergistic Synbiotic-Containing Lactiplantibacillus plantarum and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein 136. METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway 137. Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth 138. A humanized anti-MSLN× 4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity 139. MORF4L2 induces immunosuppressive microenvironment and immunotherapy resistance through GRHL2/MORF4L2/H4K12Ac/CSF1 axis in triple-negative breast cancer 140. Gut–liver translocation of pathogen Klebsiella pneumoniae promotes hepatocellular carcinoma in mice 141. S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway