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BALB/cJGpt

BALB/cJGpt|Strain NO.N000020

Inbred strain

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BASIC INFORMATION
Strain Name: BALB/cJGpt
Strain Number: N000020
Strain Strategy: N000020.BALB_cJGpt strain info.pdf
Research Areas: Inbred line
Strain Background: [N000020] BALB/cJGpt
Modification Type: Inbred strain
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice. Food & Function (2020)2. The third generation anti-HER2 chimeric antigen receptor mouse T cells alone or together with anti-PD1 antibody inhibits the growth of mouse breast tumor cells expressing HER2 in vitro and in immune competent mice. Frontiers in Oncology (2020)3. CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK. Oncogene (2020)4. Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer. Nature Immunology (2021)5. Creatine promotes cancer metastasis through activation of Smad2/3. Cell metabolism (2021)6. Iron Doped Carbon Dots based Nanohybrids as a Tetramodal Imaging Agent for Gene Delivery promotion and Photothermal-Chemodynamic Cancer Synergistic Theranostics. Materials & Design (2021)7. Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression. Cell death & disease (2021)8. Polymer-directed supramolecular assembly of photosensitizers: Evocation of photothermal effect and highly efficient loading of disulfiram for chemo-phototherapy of cancer. Applied Materials Today (2021)9. PPARγ mediates the anti-epithelial-mesenchymal transition effects of FGF1ΔHBS in chronic kidney diseases via inhibition of TGF-β1/SMAD3 signaling. Frontiers in pharmacology (2021)10. Transdermal delivery of heparin using low-frequency sonophoresis in combination with sponge spicules for venous thrombosis treatment. Biomaterials Science (2021)11. Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and Pcsk9 siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer. ACS Applied Materials & Interfaces (2022)12. Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology. Journal of Medicinal Chemistry (2022)13. Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments. Nat Commun (2022)14. Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation. J Immunother Cancer (2022)15. Magnetic Fields Affect Alcoholic Liver Disease by Liver Cell Oxidative Stress and Proliferation Regulation. Research (2023)16. Controlled intracellular aggregation of magnetic particles improves permeation and retention for magnetic hyperthermia promotion and immune activation. Theranostics (2023)17. EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1. Adv Sci (2023)18. ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy. Adv Healthc Mater (2023)19. Stimuli-responsive heparin-drug conjugates co-assembled into stable nanomedicines for cancer therapy. Acta Biomater (2023)20. Design of a novel chimeric peptide via dual blockade of CD47/SIRPalpha and PD-1/PD-L1 for cancer immunotherapy. Sci China Life Sci (2023)21. Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging. SCI ADV (2023)22. LncRNA UCA1 Participates in De Novo Synthesis of Guanine Nucleotides in Bladder Cancer by Recruiting TWIST1 to Increase IMPDH1/2. Int J Biol Sci (2023)23. FGF19-Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer. Adv Sci (2023)24. Glutathione-Exhausting Nanoprobes for NIR-II Fluorescence Imaging-Guided Surgery and Boosting Radiation Therapy Efficacy via Ferroptosis in Breast Cancer. ACS Nano (2023)25. Near-Infrared Persistent Luminescence Nanoprobe for Ultrasensitive Image-Guided Tumor Resection. Adv Sci (2023)26. Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease. Carbohydr Polym (2023)27. Gastric Acid-Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora. Adv Sci (2023)28. The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma. Cell Death Dis (2023)29. Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway. J Cancer (2023)30. Appendectomy Mitigates Coxsackievirus B3−Induced Viral Myocarditis. Viruses (2023)31. B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation. JHEP Reports (2023)32. Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR. J Transl Med (2023)33. Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer. Cell Death Dis (2023)34. PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype. Genes & Diseases (2023)35. Enhanced Chemo-Immunotherapy Strategy Utilizing Injectable Thermosensitive Hydrogel for The Treatment of Diffuse Peritoneal Metastasis in Advanced Colorectal Cancer. Adv Sci (2023)36. Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response. Nat Prod Bioprospect (2023)37. Long-term assessment of cutaneous inflammation and treatment using optical resolution photoacoustic microscopy. Biomed Opt Express (2023)38. SARS-CoV-2 mRNA vaccine requires signal peptide to induce antibody responses. Vaccine (2023)39. Engineered oncolytic bacteria HCS1 exerts high immune stimulation and safety profiles for cancer therapy. Theranostics (2023)40. Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine. Cell Rep Med (2023)41. Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation. Sleep Breath (2023)42. Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect. J Virol (2023)43. Blocking MyD88 signaling with MyD88 inhibitor prevents colitis-associated colorectal cancer development by maintaining colonic microbiota homeostasis. Sci Rep (2023)44. Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis. J Nanobiotechnology (2023)45. Decitabine/paclitaxel co-delivery systems modified with anti-PD-L1 antibodies mediate chemoimmunotherapy for Triple negative breast cancer. Materials & Design (2024)46. Dual‑directional effect of vinorelbine combined with cisplatin or fluorouracil on tumor growth and metastasis in metronomic chemotherapy in breast cancer. Int J Oncol (2024)47. Empagliflozin alleviates the development of autoimmune myocarditis via inhibiting NF-kappaB-dependent cardiomyocyte pyroptosis. Biomed Pharmacother (2023)48. Nano-modulators with the function of disrupting mitochondrial Ca(2+) homeostasis and photothermal conversion for synergistic breast cancer therapy. J Nanobiotechnology (2023)49. PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer. J Nanobiotechnology (2023)50. Retinoic acid-inducible gene-1 knockdown induces immature properties in dendritic cells and prolongs the survival time of allograft mice. Gene (2023)51. TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5. iScience (2024)52. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism. Advanced Science (2023)53. MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning. Cell Biosci (2024)54. BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation. Molecular Medicine (2024)55. LncRNA CHROMR/miR-27b-3p/MET axis promotes the proliferation, invasion and contributes to rituximab resistance in diffuse large B-cell lymphoma. J Biol Chem (2024)56. Usenamine A triggers NLRP3 caspase-1 GSDMD-mediated pyroptosis in lung adenocarcinoma by targeting the DDX3X SQSTM1 axis. Aging-US (2024)57. Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis. bioRxiv (2024)58. CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway. J Cancer (2024)59. AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. Emerg Microbes Infect (2024)60. LncRNA CHROMR/miR-27b-3p/MET axis promotes the proliferation, invasion, and contributes to rituximab resistance in diffuse large B-cell lymphoma. J Biol Chem (2024)61. A Free Amino Acid Diet Alleviates Colorectal Tumorigenesis through Modulating Gut Microbiota and Metabolites. Nutrients (2024)62. Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma. Cell Death Dis (2024)63. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater (2024)64. Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation. Cell Death Discov (2024)65. The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis. Cell Death Dis (2024)66. An induced mutation of ABC-transporter component VraF(K84E) contributes to vancomycin resistance and virulence in Staphylococcus aureus strain MW2. Int J Med Microbiol (2024)67. Biomimetic Hydrogel-Mediated Mechano-Immunometabolic Therapy for Inhibition of ccRCC Recurrence After Surgery. Adv Sci (2024)68. Fc-Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies. J Immunother Cancer (2024)69. VISTA‐targeted antibody‐drug conjugates exhibit potent antitumor effects on malignant pleural mesothelioma. MedComm (2024)70. Protective effects of Bacillus amyloliquefaciens-derived nonapeptide in cyclophosphamide-induced immunosuppressed mice. Journal of Functional Foods (2024)71. Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma. Nat Cell Biol (2024)72. The rheumatoid arthritis drug auranofin exerts potent anti-lymphoma effect by stimulating TXNRD-mediated ROS generation and inhibition of energy metabolism. Redox Biol (2024)73. TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors. Cell Biosci (2024)74. Exposure to microcystin-LR promotes the progression of colitis-associated colorectal cancer by inducing barrier disruption and gut microbiota dysbiosis. Ecotoxicol Environ Saf (2024)75. A High Immune-Related Index with the Suppression of cGAS-STING Pathway is a Key Determinant to Herceptin Resistance in HER2+ Breast Cancer. Int J Biol Sci (2024)76. (19)F MRI/CEUS Dual Imaging-Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple-Negative Breast Cancer. Adv Sci (2024)77. Immunogen characterization reveals an intrinsic hindrance in eliciting neutralizing antibodies against JN.1 variant. iScience (2024)78. Role of TSP-1 and its receptor ITGB3 in the renal tubulointerstitial injury of focal segmental glomerulosclerosis. J Biol Chem (2024)79. alpha-Lactalbumin mRNA-LNP Evokes an Anti-Tumor Effect Combined with Surgery in Triple-Negative Breast Cancer. Pharmaceutics (2024)80. Suppression of pathological neovascularization by anti-Flt1 peptide functionalized DNA tetrahedron. Chemical Engineering Journal (2024)81. Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery. Nat Commun (2024)82. Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis. Nat Commun (2024)83. Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE(2) production. Cell Rep (2024)84. Trim21-mediated CCT2 ubiquitination suppresses malignant progression and promotes CD4(+)T cell activation in breast cancer. Cell Death Dis (2024)85. Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma. Acta Pharmacol Sin (2024)86. Preclinical Efficacy of Cap-Dependent and Independent mRNA Vaccines against Bovine Viral Diarrhea Virus-1. Veterinary Sciences (2024)87. GelMA loaded with platelet lysate promotes skin regeneration and angiogenesis in pressure ulcers by activating STAT3. Sci Rep (2024)88. Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis. Mol Neurobiol (2024)89. Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer. Heliyon (2024)90. 19F MRI/CEUS Dual Imaging‐Guided Sonodynamic Therapy Enhances Immune Checkpoint Blockade in Triple‐Negative Breast Cancer. Advanced Science (2024)91. The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells. Journal of Translational Medicine (2024)92. Microcystin-LR Regulates Interaction between Tumor Cells and Macrophages via the IRE1α/XBP1 Signaling Pathway to Promote the Progression of Colorectal Cancer. Cells (2024)93. Natural agents derived Pickering emulsion enabled by silica nanoparticles with enhanced antibacterial activity against drug-resistant bacteria. Journal of Colloid and Interface Science (2024)94. Apoptotic vesicles (apoVs) derived from fibroblast-converted hepatocyte-like cells effectively ameliorate liver fibrosis. Journal of Nanobiotechnology (2024)95. Nanobody-Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING-Mediated Anti-Tumor Immunity. Advanced Science (2024)96. Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2. Cell Commun Signal (2024)97. Local administration of mRNA encoding cytokine cocktail confers potent anti-tumor immunity. Frontiers in Immunology (2024)98. Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy. Journal for ImmunoTherapy of Cancer (2024)99. FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity. Cancer Letters (2024)100. Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I. J Transl Med (2024)101. Photothermal Catalytic Reduction and Bone Tissue Engineering Towards a Three-in-One Therapy Strategy for Osteosarcoma. Adv Mater (2024)102. Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells. Front Immunol (2024)103. Enhanced tumor targeting and penetration of fluorophores via iRGD peptide conjugation: a strategy for the precision targeting of lung cancer. Translational Lung Cancer Research (2024)104. Metal-phenolic-network-coated gold nanoclusters for enhanced photothermal/chemodynamic/immunogenic cancer therapy. Bioact Mater (2024)105. Multiplex antimicrobial activities of the self-assembled amphiphilic polypeptide β nanofiber KF-5 against vaginal pathogens. Biol Direct (2024)106. The protective effect and immunomodulatory ability of orally administrated Lacticaseibacillus rhamnosus GG against Mycoplasma pneumoniae infection in BALB/c mice. PLoS One (2024)107. Dynamic transition of Tregs to cytotoxic phenotype amid systemic inflammation in Graves' ophthalmopathy. JCI Insight (2024)108. Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles. Theranostics (2024)109. Egg White Diet Induces Severe Allergic Enteritis in an Animal Model Driven by Caspase-3 and Gasdermin C-Mediated Mucosal Alarmin Secretion. J Agric Food Chem (2024)110. Dyna-vivo-seq unveils cellular RNA dynamics during acute kidney injury via in vivo metabolic RNA labeling-based scRNA-seq. Nat Commun (2024)111. Social isolation promotes tumor immune evasion via β2-adrenergic receptor. Brain Behav Immun (2024)112. TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation. Oncol Res (2024)113. A protocol for high-throughput screening for small chemicals promoting macrophage-mediated tumor cell phagocytosis in mice. STAR protocols (2024)114. OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment. EBioMedicine (2024)115. Signature of Immune-Related Metabolic Genes Predicts the Prognosis of Hepatocellular Carcinoma. Frontiers in Immunology (2024)116. Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis. Exp Hematol Oncol (2024)117. Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity. Cell Death Dis (2024)118. MTHFD1 Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the PI3K‐AKT–mTOR Signaling Pathway. Cancer Med (2024)119. NOP10 predicts poor prognosis and promotes pancreatic cancer progression. BMC Cancer (2024)120. Smart Persistent Luminescence Imaging for Early Diagnosis of Drug-Induced Liver Injury. Chemical & Biomedical Imaging (2024)121. Ruthenium (II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy. Adv Sci (Weinh) (2024)122. Defining the features and structure of neutralizing antibody targeting the silent face of the SARS‐CoV‐2 spike N‐terminal domain. MedComm (2024)123. A cascade X-ray energy converting approach toward radio-afterglow cancer theranostics. Nat Nanotechnol (2024)124. Heart ultrasound and biomechanical evaluation of radiation‐induced heart toxicity using transthoracic echocardiogram (TTE) and dynamic mechanical analysis (DMA). Precision Radiation Oncology (2024)125. Radiation induced liver injury (RILI) evaluation using longitudinal computed tomography (CT) in image‐guided precision murine radiotherapy. Precision Radiation Oncology (2024)126. Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis. J Med Chem (2024)127. ZNF655 involved in the progression of multiple myeloma via the activation of AKT. Cell Biol Int (2024)128. Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target. Cell (2025)129. Imbalance of oral microbiome homeostasis: the relationship between microbiota and the occurrence of dental caries. (2025)130. Preclinical evaluation of 68Ga‐labeled peptides for targeting CD44 imaging. (2025)131. House dust mite induced mucosal barrier dysfunction and type 2 inflammatory responses via the MAPK/AP-1/IL-24 Signaling pathway in allergic rhinitis. International immunopharmacology (2025)132. A Humanized Anti-B7H3× 4-1BB Bispecific Antibody Exerts Potent Antitumor Effects through the Activation of Innate and Adaptive Immunity. Biochemical and biophysical research communications (2025)133. SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)134. A pH-responsive magnetic-controlled nanocomposite for precise and efficient vancomycin delivery in treating prosthetic joint infections. (2025)135. Synergistic Synbiotic-Containing Lactiplantibacillus plantarum and Fructo-Oligosaccharide Alleviate the Allergenicity of Mice Induced by Soy Protein. Foods (Basel, Switzerland) (2025)136. METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)137. Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)138. A humanized anti-MSLN× 4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity. Journal of translational medicine (2025)139. MORF4L2 induces immunosuppressive microenvironment and immunotherapy resistance through GRHL2/MORF4L2/H4K12Ac/CSF1 axis in triple-negative breast cancer. (2025)140. Gut–liver translocation of pathogen Klebsiella pneumoniae promotes hepatocellular carcinoma in mice. Nature microbiology (2025)141. S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway. Investigative ophthalmology & visual science (2025)142. Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model. Journal of neuroinflammation (2025)143. FXYD5 regulates gastric cancer cell metastasis and drug resistance by EMT modulation. Cancer gene therapy (2025)144. Tunable Hierarchically Porous Gadolinium-Based Metal-Organic Frameworks for Bacteria-Targeting Magnetic Resonance Imaging and In Situ Anti-Bacterial Therapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)145. Targeting USP1 Potentiates Radiation-Induced Type I IFN-Dependent Antitumor Immunity by Enhancing Oligo-Ubiquitinated SAR1A-Mediated STING Trafficking and Activation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)146. TRIM22 inhibits the metastasis of colorectal cancer through facilitating β-Catenin degradation. Experimental cell research (2025)147. A Hf(IV)-Coordinated NIR-II Fluorescence "Turn-On" Nanoprobe for Precise Imaging-Guided Surgery in Breast Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)148. Helicobacter pylori activates DOPEY1 to promote p53 degradation through the USP7/TRIP12 axis in gastric tumorigenesis. Oncogene (2025)149. A tumor-targeting black phosphorus-based nanoplatform for controlled chemo-photothermal therapy of breast cancer. Materials today. Bio (2025)150. A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination. Immunity (2025)151. WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis. Nature communications (2025)