BALB/cNj-Foxn1^nu/Gpt

BALB/c-Nude|Strain NO.D000521

Spontaneous Mutation

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BASIC INFORMATION

Strain Name:	BALB/cNj-Foxn1^nu/Gpt
Strain Number:	D000521
Official Symbol:	Foxn1
Strain Strategy:	D000521.BALB_c-Nude strain info.pdf
Official Full Name:	forkhead box N1
Also Known As:	D11Bhm185e,Fkh19,HFH-11,Hfh11,Whn,nu,nude
NCBI Number:	15218
MGI Number:	102949
Chromosome:	11
Research Areas:	immunodeficiency,Other immunodeficient strains
Strain Background:	[N000020] BALB/cJGpt
Modification Type:	Spontaneous Mutation
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. A dynamic DNA tetrahedron framework for active targeting 2. Highly efficient fabrication of functional hepatocyte spheroids by a magnetic system for the rescue of acute liver failure 3. DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2 4. Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-beta/SMAD3 pathway 5. Targeting FAPα-expressing hepatic stellate cells overcomes resistance to anti-angiogenics in colorectal cancer liver metastasis models 6. Generation of a live attenuated influenza A vaccine by proteolysis targeting 7. Allosteric activation of the metabolic enzyme GPD1 inhibits bladder cancer growth via the lysoPC-PAFR-TRPV2 axis 8. Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis: therapeutic potential for endogenous pulp regeneration 9. A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies 10. Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm 11. NIR‐Activated Multimodal Photothermal/Chemodynamic/Magnetic Resonance Imaging Nanoplatform for Anticancer Therapy by Fe (II) Ions Doped MXenes (Fe‐Ti3C2)12. A framework nucleic acid based robotic nanobee for active targeting therapy 13. Polypeptide uploaded efficient nanophotosensitizers to overcome photodynamic resistance for enhanced anticancer therapy 14. Cell‐Released Magnetic Vesicles Capturing Metabolic Labeled Rare Circulating Tumor Cells Based on Bioorthogonal Chemistry 15. MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage 16. TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα 17. Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells 18. Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity 19. Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy 20. Heat stress activates YAP/TAZ to induce the heat shock transcriptome 21. Integrated omics of metastatic colorectal cancer 22. Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma 23. Clonal mutations activate the NF-κB pathway to promote recurrence of nasopharyngeal carcinoma 24. In Vivo Bioorthogonal Labeling of Rare-Earth Doped Nanoparticles for Improved NIR-II Tumor Imaging by Extracellular Vesicle-Mediated Targeting 25. Rational Design of pH-Activated Upconversion Luminescent Nanoprobes for Bioimaging of Tumor Acidic Microenvironment and the Enhancement of Photothermal Therapy 26. FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer 27. MAP7D2 reduces CD8(+) cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer 28. The synergistic regulation of chondrogenesis by collagen-based hydrogels and cell co-culture 29. Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth 30. TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma 31. Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation 32. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme 33. Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system 34. Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment 35. Orthogonal excitations of lanthanide nanoparticle up/down conversion emissions via switching NIR lights for in-vivo theranostics 36. A carbon monoxide releasing metal organic framework nanoplatform for synergistic treatment of triple-negative breast tumors 37. Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation 38. CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug 39. CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin 40. Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs 41. The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling 42. BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer 43. A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers 44. Phosphomevalonate Kinase Controls beta-Catenin Signaling via the Metabolite 5-Diphosphomevalonate 45. Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations 46. Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes beta-catenin palmitoylation to drive colorectal cancer progression 47. METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression 48. Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells 49. A radiohybrid theranostics ligand labeled with fluorine-18 and lutetium-177 for fibroblast activation protein-targeted imaging and radionuclide therapy 50. Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy 51. LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia 52. Nano-magnetic aptamer sensor incorporating AND logic recognition-launched hybridization chain reaction for organ origin identification of circulating tumor cells 53. CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway 54. EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1 55. Stimuli-responsive heparin-drug conjugates co-assembled into stable nanomedicines for cancer therapy 56. The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma 57. PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells 58. Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 59. SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool 60. SUMO specific peptidase 3 halts pancreatic ductal adenocarcinoma metastasis via deSUMOylating DKC1 61. Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling 62. Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy 63. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma 64. Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer 65. NOTCH4(DeltaL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1 66. Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC 67. Chronic stress accelerates glioblastoma progression via DRD2/ERK/beta-catenin axis and Dopamine/ERK/TH positive feedback loop 68. Inhibition of DPAGT1 suppresses HER2 shedding and trastuzumab resistance in human breast cancer 69. Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis 70. A biomimetic nanoreactor for combinational chemo/chemodynamic therapy of choriocarcinoma through synergistic apoptosis and ferroptosis strategy 71. CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression 72. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer 73. FOXP1-GINS1 axis promotes DLBCL proliferation and directs doxorubicin resistance 74. HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway 75. Inetetamab, a novel anti-HER2 monoclonal antibody, exhibits potent synergistic anticancer effects with cisplatin by inducing pyroptosis in lung adenocarcinoma 76. Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation 77. PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair 78. A mitochondrial EglN1-AMPKalpha axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress 79. A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer 80. CLASRP oncogene as a novel target for colorectal cancer 81. DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer 82. ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer 83. Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer 84. In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy 85. LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer 86. LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter 87. Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer 88. Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors 89. Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression 90. Beauvericin suppresses the proliferation and pulmonary metastasis of osteosarcoma by selectively inhibiting TGFBR2 pathway 91. Design, Synthesis, and Biological Evaluation of a Novel [(18)F]-Labeled Arginine Derivative for Tumor Imaging 92. Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer 93. Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling 94. Heat shock protein B7 (HSPB7) inhibits lung adenocarcinoma progression by inhibiting glycolysis 95. High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma 96. LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter 97. LINC00926 promotes progression of renal cell carcinoma via regulating miR-30a-5p/SOX4 axis and activating IFNgamma-JAK2-STAT1 pathway 98. M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1 99. Overexpression of HSPB6 inhibits osteosarcoma progress through the ERK signaling pathway 100. PHACTR1 promotes the mobility of papillary thyroid carcinoma cells by inducing F-actin formation 101. PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma 102. RACK1 facilitates breast cancer progression by competitively inhibiting the binding of beta-catenin to PSMD2 and enhancing the stability of beta-catenin 103. Rational Design of Bioorthogonally Activatable PROTAC for Tumor-Targeted Protein Degradation 104. SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFβ1/Smad signaling pathway 105. Silencing GMPPB Inhibits the Proliferation and Invasion of GBM via Hippo/MMP3 Pathways 106. Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma 107. TBX3 promotes the epithelial mesenchymal transition of cervical cancer by upregulating ID1 108. The role of Her-2 in penile squamous cell carcinoma progression and cisplatin chemoresistance and potential for antibody-drug conjugate-based therapy 109. URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers 110. USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress 111. WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2 112. Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression 113. Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma 114. Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer 115. Epidermal-dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures 116. HILPS, a long noncoding RNA essential for global oxygen sensing in humans 117. Hsa_circ_0020134 promotes liver metastasis of colorectal cancer through the miR-183-5p-PFN2-TGF-beta/Smad axis 118. Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance 119. PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies 120. SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/beta-catenin signaling in colorectal carcinoma 121. Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG 122. SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma 123. Synaptotagmin 1 Suppresses Colorectal Cancer Metastasis by Inhibiting ERK/MAPK Signaling-Mediated Tumor Cell Pseudopodial Formation and Migration 124. The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity 125. The m(7)G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling 126. Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway 127. TSTA3 overexpression promotes malignant characteristics in LUSC by regulating LAMP2-mediated autophagy and tumor microenvironment 128. Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma 129. ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape 130. ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3 131. Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis 132. Essential genes analysis reveals small ribosomal subunit protein eS28 may be a prognostic factor and potential vulnerability in osteosarcoma 133. Exploring the potential of carbon-coated MoSe2 nanoparticles as a photothermal therapy for ovarian cancer 134. HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism 135. hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma 136. Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a 137. PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors 138. POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6 139. Predictive role of E2F6 in cancer prognosis and responses of immunotherapy 140. PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer 141. Single-particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier 142. S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation 143. Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1 144. Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3beta axis in non-small cell lung cancer 145. ID2 promotes tumor progression and metastasis in thyroid cancer 146. Regulation of tumor metastasis and CD8(+) T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer 147. ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma 148. WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling 149. Baicalin alleviates chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor 150. The miR-19a/Cylindromatosis Axis Regulates Pituitary Adenoma Bone Invasion by Promoting Osteoclast Differentiation 151. FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2alpha blockade by facilitating LDHA phosphorylation 152. Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway 153. Jinfukang inhibits lung cancer metastasis by regulating T cell receptors 154. Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting 155. Ellagic acid inhibits tumor growth and potentiates the therapeutic efficacy of sorafenib in hepatocellular carcinoma 156. Targeting DAD1 gene with CRISPR-Cas9 system transmucosally delivered by fluorinated polylysine nanoparticles for bladder cancer intravesical gene therapy 157. Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway 158. ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma 159. Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain 160. Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy 161. Proteomic analysis reveals LRPAP1 as a key player in the micropapillary pattern metastasis of lung adenocarcinoma 162. SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFbeta1/Smad signaling pathway 163. MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning 164. CYB561 promotes HER2+ breast cancer proliferation by inhibiting H2AFY degradation 165. Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression 166. Radiotherapy-Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth 167. Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells 168. Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in gastric cancer 169. Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker 170. Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells 171. ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9 172. SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway 173. Vasorin exocytosed from glioma cells facilitates angiogenesis via VEGFR2 AKT signaling pathway 174. Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway 175. Transmembrane protein 176B regulates amino acid metabolism through the PI3K-Akt-mTOR signaling pathway and promotes gastric cancer progression 176. Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1 177. Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer 178. Abnormal upregulation of NUBP2 contributes to cancer progression in colorectal cancer 179. Activation of the FOXM1/ASF1B/PRDX3 axis confers hyperproliferative and antioxidative stress reactivity to gastric cancer 180. PELI1: key players in the oncogenic characteristics of pancreatic Cancer 181. NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization 182. Membrane-associated RING-CH 7 inhibits stem-like capacities of bladder cancer cells by interacting with nucleotide-binding oligomerization domain containing 1 183. Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway 184. FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation 185. FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA 186. GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism 187. Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair 188. BZW2 promotes malignant progression in lung adenocarcinoma through enhancing the ubiquitination and degradation of GSK3beta 189. Characterization of AST-001 non-clinical pharmacokinetics: A novel selective AKR1C3-activated prodrug in mice, rats, and cynomolgus monkeys 190. Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway 191. Self-Assembled DNA Composite-Engineered Mesenchymal Stem Cells for Improved Skin-Wound Repair 192. TNF-alpha-Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy-Related Protein VCP
Gene Family:	Forkhead boxes