C57BL/6JGpt

C57BL/6JGpt|Strain NO.N000013

Inbred strain

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt
Strain Number:	N000013
Official Symbol:	/
Strain Strategy:	N000013.C57BL_6JGpt strain info.pdf
NCBI Number:	/
Research Areas:	Inbred line
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Inbred strain
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage-Myofibroblast Transition in Bladder Remodeling 2. Natural Cell Patches: Melanin Nanoparticles for MR Imaging‐Guided Antiatherosclerosis Therapy via Attenuating Macrophage Pyroptosis 3. Construction of a cross-species cell landscape at single-cell level 4. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination 5. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4 6. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia 7. Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver 8. Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway 9. Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation 10. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism 11. IL‐36γ and IL‐36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress‐Induced Cell Death 12. Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies 13. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics 14. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice 15. ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer 16. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity 17. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease 18. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors 19. Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer 20. Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy 21. PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery 22. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo 23. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity 24. N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression 25. Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury 26. CD11b(+) CD43(hi) Ly6C(lo) splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis 27. Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease 28. MAP7D2 reduces CD8(+) cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer 29. Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice 30. The m(6)A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia 31. α-D-1,3-glucan from Radix Puerariae thomsonii improves NAFLD by regulating the intestinal flora and metabolites 32. Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming 33. Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis 34. TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma 35. Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation 36. Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route 37. Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor 38. Single cell sequencing reveals that CD39 inhibition mediates changes to the tumor microenvironment 39. Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice 40. Long-term cadmium exposure impairs cognitive function by activating lnc-Gm10532/m6A/FIS1 axis-mediated mitochondrial fission and dysfunction 41. Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice 42. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells 43. Use of intercellular proximity labeling to quantify and decipher cell-cell interactions directed by diversified molecular pairs 44. Macrophage GSK3beta-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy 45. Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFbeta2/ALK1 axis 46. FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury 47. Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction 48. Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis 49. Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice 50. FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke 51. Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis 52. Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis 53. Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression 54. G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes 55. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases 56. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction 57. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses 58. PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy 59. PES1 reduces CD8(+) T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma 60. Bioabsorbable nano-micelle hybridized hydrogel scaffold prevents postoperative melanoma recurrence 61. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism 62. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy 63. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer 64. Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice 65. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice 66. Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer 67. The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway 68. Upregulation of beta-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain 69. Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury 70. C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape 71. Design of a novel chimeric peptide via dual blockade of CD47/SIRPalpha and PD-1/PD-L1 for cancer immunotherapy 72. Dysregulated Gln-Glu-alpha-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage 73. Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis 74. Malic Enzyme 1 as a Novel Anti-Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury 75. beta-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice 76. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma 77. Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca(2+) overload 78. Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice 79. Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice 80. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes 81. The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma 82. Zoledronic acid and thymosin alpha1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells 83. Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils 84. Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells 85. Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy 86. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing 87. The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice 88. Chronic stress accelerates glioblastoma progression via DRD2/ERK/beta-catenin axis and Dopamine/ERK/TH positive feedback loop 89. Flavonoid Derivative DMXAA Attenuates Cisplatin-induced Acute Kidney Injury Independent of STING Signaling 90. Vimentin affects inflammation and neutrophil recruitment in airway epithelium during Streptococcus suis serotype 2 infection 91. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke 92. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice 93. RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A 94. Administration of AG490 decreases the senescence of umbilical cord-mesenchymal stem cells and promotes the cytotherapeutic effect in liver fibrosis 95. Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides 96. Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy 97. Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer 98. Development and Validation of Robust Ferroptosis-Related Genes in Myocardial Ischemia-Reperfusion Injury 99. Intravesical chemotherapy synergize with an immune adjuvant by a thermo-sensitive hydrogel system for bladder cancer 100. Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway 101. Microglia sense and suppress epileptic neuronal hyperexcitability 102. Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast 103. Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization 104. PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1 105. Pomegranate-derived exosome-like nanovesicles ameliorate high-fat diet-induced nonalcoholic fatty liver disease via alleviating mitochondrial dysfunction 106. PPARalpha/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach 107. Sandwich-Structured Implants to Obstruct Multipath Energy Supply and Trigger Self-Enhanced Hypoxia-Initiated Chemotherapy Against Postsurgical Tumor Recurrence and Metastasis 108. Multi-omics reveals aspirin eugenol ester alleviates neurological disease 109. Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes 110. C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome 111. Antigen priming induces functional reprogramming in iNKT cells via metabolic and epigenetic regulation An insight into iNKT cell-based anti-tumor immunotherapy 112. Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration 113. DOCK8 inhibits the immune function of neutrophils in sepsis by regulating aerobic glycolysis 114. Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy 115. Enteric fungi protect against intestinal ischemia-reperfusion injury via inhibiting the SAA1-GSDMD pathway 116. HIVEP3 inhibits fate decision of CD8+ invariant NKT cells after positive selection 117. Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice 118. Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics 119. J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-kappaB signaling pathway 120. Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing 121. Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis 122. Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells 123. PC3T: a signature-driven predictor of chemical compounds for cellular transition 124. Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate 125. Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors 126. Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin 127. Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria 128. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages 129. The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice 130. Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis 131. Astragaloside IV Ameliorates Inflammatory Damage in Mice with Acute Liver Failure 132. Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling 133. CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis 134. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation 135. Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway 136. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease 137. Engineered oncolytic bacteria HCS1 exerts high immune stimulation and safety profiles for cancer therapy 138. Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100beta under high-altitude conditions 139. Evaluation of time-dependent phenotypes of myocardial ischemia-reperfusion in mice 140. GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure 141. HBV suppresses macrophage immune responses by impairing the TCA cycle through the induction of CS/PDHC hyperacetylation 142. Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis 143. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis 144. IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma 145. Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus-Angelica sinensis Codecoction 146. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity 147. Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer 148. Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis 149. MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-kappaB pathway 150. Novel cannabinoid receptor 1 inverse agonist CRB-913 enhances efficacy of tirzepatide, semaglutide, and liraglutidein the diet-induced obesity mouse model 151. Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine 152. Oxymatrine inhibits melanoma development by modulating the immune microenvironment and targeting the MYC/PD-L1 pathway 153. PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation 154. Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress 155. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease 156. MircroRNA-92b as a negative regulator of the TGF-beta signaling by targeting the type I receptor 157. Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression 158. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis 159. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1 160. A single-cell transcriptomic atlas characterizes age-related changes of murine cranial stem cell niches 161. Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma 162. Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes 163. Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma 164. Costal Cartilage Graft Repair Osteochondral Defect in a Mouse Model 165. Discovery of Zidovudine as a cardiomyocyte protectant for doxorubicin-induced toxicity through high-throughput phenotypic drug screening 166. Does decreased autophagy and dysregulation of LC3A in astrocytes play a role in major depressive disorder?167. Group 3 Innate Lymphoid Cells Exacerbate Lupus Nephritis by Promoting B Cell Activation in Kidney Ectopic Lymphoid Structures 168. Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction 169. Hollow Cu2MoS4 nanoparticles loaded with immune checkpoint inhibitors reshape the tumor microenvironment to enhance immunotherapy for pancreatic cancer 170. Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect 171. Interferon stimulated immune profile changes in a humanized mouse model of HBV infection 172. Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes 173. Metabolomics study reveals increased deoxycholic acid contributes to deoxynivalenol-mediated intestinal barrier injury 174. Mirabegron displays anticancer effects by globally browning adipose tissues 175. PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage 176. Protective effects of metformin on pancreatic beta-cell ferroptosis in type 2 diabetes in vivo 177. Temporal dynamics and composition of ocular surface microbiota in C57BL/6J mice: uncovering a 12h ultradian rhythm 178. The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3–SRF axis 179. Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer 180. Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance 181. The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity 182. Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma 183. A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection 184. Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway 185. Bile acid metabolomics identifies chenodeoxycholic acid as a therapeutic agent for pancreatic necrosis 186. Comprehensive Analysis of PANoptosis-Related Gene Signature of Ulcerative Colitis 187. CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway 188. Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling 189. Foxa2 attenuates steatosis and inhibits the NF-kappaB/IKK signaling pathway in nonalcoholic fatty liver disease 190. Gut Microbial Diversity Analysis of Different Native Chickens and Screening of Chicken-Derived Probiotics 191. Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation 192. Liver Regeneration-Related Genes of Nontumor Liver Tissues Predict the Prognosis of Patients with Hepatocellular Carcinoma 193. Magnetic Metal-Organic Framework-Based Nanoplatform with Platelet Membrane Coating as a Synergistic Programmed Cell Death Protein 1 Inhibitor against Hepatocellular Carcinoma 194. MiR-192-5p Ameliorates Hepatic Lipid Metabolism in Non-Alcoholic Fatty Liver Disease by Targeting Yy1 195. Muscone ameliorates myocardial ischemia‒reperfusion injury by promoting myocardial glycolysis 196. Retinoic acid-inducible gene-1 knockdown induces immature properties in dendritic cells and prolongs the survival time of allograft mice 197. Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries 198. Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy 199. Tetrahedral framework nucleic acid loaded with glabridin: A transdermal delivery system applicated to anti-hyperpigmentation 200. Time-restricted feeding alleviates metabolic implications of circadian disruption by regulating gut hormone release and brown fat activation 201. Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic beta-Cell Impairment 202. Single-particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier 203. Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2 204. Extracellular vesicles released by transforming growth factor-beta 1-preconditional mesenchymal stem cells promote recovery in mice with spinal cord injury 205. Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis 206. Bioinformatic analysis and in vivo validation of angiogenesis related genes in inflammatory bowel disease.>207. Si-Zhi Wan regulates osteoclast autophagy in osteoporosis through the AMPK signaling pathway to attenuate osteoclastogenesis 208. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response 209. LIM1863 is useful to explore collective cancer cell migration, and the group of heterogeneous cells undergoing collective migration behaves like a supracellular unit.210. Biphasic calcium phosphate recruits Tregs to promote bone regeneration 211. The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy-induced osteoporosis 212. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery 213. Jinfukang inhibits lung cancer metastasis by regulating T cell receptors 214. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging 215. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism 216. Identification and validation of key biomarkers associated with macrophages in nonalcoholic fatty liver disease based on hdWGCNA and machine learning 217. Paternal preconceptional supplementation of n‐3 polyunsaturated fatty acids alleviates offspring nonalcoholic fatty liver disease in high‐fat diet‐induced obese mice 218. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction 219. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson's disease 220. Hepatitis B virus-mediated sodium influx contributes to hepatic inflammation via synergism with intrahepatic danger signals 221. MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning 222. Knockdown of Slfn5 alleviates lipopolysaccharide-induced pneumonia by regulating Janus kinase/signal transduction and activator of transcription pathway 223. Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function 224. Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation.pdf 225. Inhibition of 15-hydroxyprostaglandin dehydrogenase protects neurons from ferroptosis in ischemic stroke 226. Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS 227. Enteral nutrition promotes the remission of colitis by gut bacteria-mediated histidine biosynthesis 228. BCG immunotherapy promotes tumor-derived T-cell activation through the FLT3/FLT3LG pathway in bladder cancer 229. Inhibition of Hyperglycemia and Hyperlipidemia by Blocking Toll-like Receptor 4: Comparison of Wild-Type and Toll-like Receptor 4 Gene Knockout Mice on Obesity and Diabetes Modeling 230. Neuromorphic electro-stimulation based on atomically thin semiconductor for damage-free inflammation inhibition 231. Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder 232. RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis 233. Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice 234. Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis 235. Downregulation of the CD151 protects the cardiac function by the crosstalk between the endothelial cells and cardiomyocytes via exosomes 236. Bee Venom Stimulates Growth Factor Release from Adipose-Derived Stem Cells to Promote Hair Growth 237. Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL 238. Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity 239. Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration 240. Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis 241. High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures 242. TREM2 Alleviates Subarachnoid Hemorrhage-Induced Brain Injury through Attenuating Neuroinflammation and Programmed Cell Death in Vivo and in Vitro 243. P53 Alleviates the Progression of Periodontitis by Reducing M1-type Macrophage Differentiation 244. Melatonin improves cholestatic liver disease via the gut-liver axis 245. Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation 246. Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKepsilon/STAT1/NLRP3 Pathway 247. Targeted delivery of Fc-fused PD-L1 for effective management of acute and chronic colitis 248. Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function 249. Urban Particulate Matter Triggers Meibomian Gland Dysfunction 250. Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway 251. Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence 252. Establishment of new transurethral catheterization methods for male mice.253. Integrated multi-omic analysis identifies fatty acid binding protein 4 as a biomarker and therapeutic target of ischemia-reperfusion injury in steatotic liver transplantation 254. GALNT12 suppresses the bone-specific prostate cancer metastasis by activating BMP pathway via the O-glycosylation of BMPR1A 255. Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection 256. Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by Disrupting Macrophage-Fibroblast Crosstalk 257. Lipopolysaccharide inhibits osteoblast formation and receptor activator of nuclear factor-kappaB ligand degradation via autophagy inhibition 258. FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion 259. Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies 260. The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis 261. Synthetic self-adjuvanted multivalent Mucin 1 (MUC1) glycopeptide vaccines with improved in vivo antitumor efficacy 262. Traditional Chinese Medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation 263. The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage 264. Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage 265. Targeting P2Y(14)R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis 266. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion 267. PLCE1 enhances mitochondrial dysfunction to promote GSDME-mediated pyroptosis in doxorubicin-induced cardiotoxicity 268. MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes 269. Maresin-1 ameliorates hypertensive vascular remodeling through its receptor LGR6 270. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes 271. Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases 272. Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke 273. Investigating the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis treatment 274. Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction 275. Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice 276. Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation 277. Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity 278. Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression 279. Establishment of new transurethral catheterization methods for male mice 280. Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects 281. Development of Small HN Linked Radionuclide Iodine-125 for Nanocarrier Image Tracing in Mouse Model 282. Endothelial cell-derived extracellular vesicles expressing surface VCAM1 promote sepsis-related acute lung injury by targeting and reprogramming monocytes 283. Astaxanthin improves skeletal muscle regeneration in CTX-induced injury of HFD-fed obese mice via mitochondrial biogenesis 284. Characterizing neuroinflammation and identifying prenatal diagnostic markers for neural tube defects through integrated multi-omics analysis 285. Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation 286. Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis 287. Aspirin Caused Intestinal Damage through FXR and ET-1 Signaling Pathways 288. Alteration of thyroid hormones in mouse models of Alzheimer's disease and aging 289. A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis 290. A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE(-/-) mice 291. Dexmedetomidine inhibits paraventricular corticotropin-releasing hormone neurons that attenuate acute stress-induced anxiety-like behavior in mice 292. Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice 293. 2'-Hydroxycinnamaldehyde Alleviates Intestinal Inflammation by Attenuating Intestinal Mucosal Barrier Damage Via Directly Inhibiting STAT3 294. Lipid and Transcriptional Regulation in a Parkinson's Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen-Based Nanomedicines 295. NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis 296. SNX8 enables lysosome reformation and reverses lysosomal storage disorder 297. Osteocyte mitochondria regulate angiogenesis of transcortical vessels 298. B cell subsets contribute to myocardial protection by inducing neutrophil apoptosis after ischemia and reperfusion 299. Label-free analysis of the beta-hydroxybutyricacid drug on mitochondrial redox states repairment in type 2 diabetic mice by resonance raman scattering 300. TNF-alpha-Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy-Related Protein VCP 301. A Stapled Peptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase Subunits METTL3 and METTL14 for Cancer Therapy 302. Adipose-derived stem cells derived decellularized extracellular matrix enabled skin regeneration and remodeling 303. Aristolochic acid induces acute kidney injury through ferroptosis 304. AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation 305. Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage 306. Engagement of N(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2 307. IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1 308. Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins 309. Exercise accelerates recruitment of CD8(+) T cell to promotes anti-tumor immunity in lung cancer via epinephrine 310. FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment 311. GRK2-YAP signaling is implicated in pulmonary arterial hypertension development 312. Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1beta-dependent macrophage activation and tubular cell senescence 313. Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-kappaB/GLUT1 and SREBP1 pathways 314. Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis 315. Longitudinal multi-omics analysis uncovers the altered landscape of gut microbiota and plasma metabolome in response to high altitude 316. Regulating Lars2 in mitochondria: A potential Alzheimer's therapy by inhibiting tau phosphorylation 317. Neuropeptide Y, a potential marker for lupus, promotes lupus development 318. NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease 319. Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis 320. Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice 321. Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism 322. Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21 323. Whole transcriptome sequencing analyses of islets reveal ncRNA regulatory networks underlying impaired insulin secretion and increased beta-cell mass in high fat diet-induced diabetes mellitus 324. A Tumor Environment-Activated Photosensitized Biomimetic Nanoplatform for Precise Photodynamic Immunotherapy of Colon Cancer 325. Dampening of ISGylation of RIG-I by ADAP regulates type I interferon response of macrophages to RNA virus infection 326. ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1p65 signaling in inflammatory bowel disease-related fibrosis 327. Endothelial cell-derived extracellular vesicles modulate the therapeutic efficacy of mesenchymal stem cells through IDH2/TET pathway in ARDS 328. Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma 329. Enhanced immunosuppressive capability of mesenchymal stem cell-derived small extracellular vesicles with high expression of CD73 in experimental autoimmune uveitis 330. Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation 331. Exosomes derived from TNF-alpha-treated bone marrow mesenchymal stem cells ameliorate myocardial infarction injury in mice 332. Exosomal LRG1 promotes non-small cell lung cancer proliferation and metastasis by binding FN1 protein 333. Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis 334. Gingival-derived mesenchymal stem cells alleviate allergic asthma inflammation via HGF in animal models 335. Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APC(min/+) Mice 336. Gut dysbiosis contributes to SCFAs reduction-associated adipose tissue macrophage polarization in gestational diabetes mellitus 337. LncRNA 4930581F22Rik promotes myogenic differentiation by regulating the ERK/MAPK signaling pathway 338. IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis 339. NET-Related Gene as Potential Diagnostic Biomarkers for Diabetic Tubulointerstitial Injury 340. METTL3 Deficiency Aggravates Hepatic Ischemia/Reperfusion Injury in Mice by Activating the MAPK Signaling Pathway 341. Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFbeta1-mediated tumor progression 342. LncRNA TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination 343. Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation 344. Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics 345. Mfn2 regulates mitochondria and mitochondria-associated endoplasmic reticulum membrane function in neurodegeneration induced by repeated sevoflurane exposure 346. Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure 347. Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis 348. Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy 349. Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis 350. Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma 351. Splenectomy ameliorates liver cirrhosis by restoring the gut microbiota balance 352. Stimulation of tumoricidal immunity via bacteriotherapy inhibits glioblastoma relapse 353. Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X 354. USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation 355. Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction 356. Bioinformatic analyses reveal lysosomal-associated protein transmembrane 5 as a potential therapeutic target in lipotoxicity-induced injury in diabetic kidney disease 357. Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis 358. A Novel Murine Model for Lupus-Like Ocular Chronic Graft-Versus-Host Disease 359. Circular RNA-based therapy provides sustained and robust neuroprotection for retinal ganglion cells 360. Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis 361. Carbon Dot Nanozyme Ameliorating Ischemia-Reperfusion-Induced Muscle Injury by Antioxidation and Downregulating iNOS/COX-2 Pathway 362. Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress 363. Hippocampal mitophagy contributes to spatial memory via maintaining neurogenesis during the development of mice 364. Lactobacillus acidophilus CICC 6075 Attenuates HFD-induced Obesity by Improving Gut Microbiota Composition and Histidine Biosynthesis 365. Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling 366. Liraglutide ameliorates TAC-induced cardiac hypertrophy and heart failure by upregulating expression level of ANP expression 367. Isaridin E Protects against Sepsis by Inhibiting Von Willebrand Factor-Induced Endothelial Hyperpermeability and Platelet-Endothelium Interaction 368. Insight into Fructose-to-Sucrose Ratio as the Potential Target of Urinalysis in Bladder Cancer 369. Niraparib enhances antitumor immunity and contributes to the efficacy of PD-L1 blockade in cervical cancer 370. Novel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity 371. Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing 372. Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection 373. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis 374. Pyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction 375. Sema4D Knockout Attenuates Choroidal Neovascularization by Inhibiting M2 Macrophage Polarization Via Regulation of the RhoA/ROCK Pathway 376. Unveiling pharmacological targets of Rihimaside C for radiation-induced lung injury: An in silico and experimental integrated approach 377. Grape seed extract prevents oestrogen deficiency-induced bone loss by modulating the gut microbiota and metabolites 378. Hypoalbuminemia contributes to ascites formation via sodium and water retention: Evidence from clinical date and albumin deficient mice 379. Limosilactobacillus fermentum TY-S11 ameliorates hypercholesterolemia via promoting cholesterol excretion and regulating gut microbiota in high-cholesterol diet-fed apolipoprotein E-deficient mice 380. Transcriptome Study of rd1Mouse Brain and Association with Parkinson's Disease 381. A neural-mast cell axis regulates skin microcirculation in diabetes 382. Postbiotics from Lactobacillus delbrueckii Alleviate Intestinal Inflammation by Promoting the Expansion of Intestinal Stem Cells in S. Typhimurium-Induced Mice 383. Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages 384. A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response 385. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway 386. The Dual‐Target Nanoparticles with ROS Sensitivity Inhibit the Hedgehog Signaling Pathway and Decrease Oxidative Stress in Activated Hepatic Stellate Cells to Alleviate Liver Fibrosis 387. Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues 388. Metabolic Profiling of Cochlear Organoids Identifies alpha-Ketoglutarate and NAD(+) as Limiting Factors for Hair Cell Reprogramming 389. ALKBH5-mediated N6-methyladenosine modification of HO-1 mRNA regulates ferroptosis in cobalt-induced neurodegenerative damage 390. Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7 391. Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel 392. Immunostimulatory effects of Toll-like receptor ligands as adjuvants in establishing a novel mouse model for pemphigus vulgaris 393. CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1 394. Cerebral Endothelial CXCR2 Promotes Neutrophil Transmigration into Central Nervous System in LPS-Induced Septic Encephalopathy 395. Hepatic IL22RA1 deficiency promotes hepatic steatosis by modulating oxysterol in the liver 396. High dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease via Activating ubiquitin-specific peptidase 2/11beta-hydroxysteroid dehydrogenase type 1 Pathway in Mice 397. HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling 398. Hepatocyte-derived FGL1 accelerates liver metastasis and tumor growth by inhibiting CD8+ T and NK cells 399. Identification of the CDH18 gene associated with age-related macular degeneration using weighted gene co-expression network analysis 400. Mesenchymal stem cell-derived exosomes ameliorate diabetic kidney disease through NOD2 signaling pathway 401. The role of miR-128 and MDFI in cardiac hypertrophy and heart failure: Mechanistic 402. Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU 403. Miao sour soup alleviates DSS-induced colitis in mice: modulation of gut microbiota and intestinal barrier function 404. Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers 405. Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165 406. Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress 407. S100A9 as a Key Myocardial Injury Factor Interacting with ATP5 Exacerbates Mitochondrial Dysfunction and Oxidative Stress in Sepsis-Induced Cardiomyopathy 408. Rose Bengal diacetate-mediated antimicrobial photodynamic inactivation: potentiation by potassium iodide and acceleration of wound healing in MRSA-infected diabetic mice 409. Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury 410. Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation 411. CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation 412. Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway 413. Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis 414. Screening of active components in Astragalus mongholicus Bunge and Panax notoginseng formula for anti-fibrosis in CKD: nobiletin inhibits Lgals1/PI3K/AKT signaling to improve renal fibrosis 415. siRNA-loaded folic acid-modified TPGS alleviate MASH via targeting ER stress sensor XBP1 and reprogramming macrophages 416. SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration 417. Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration 418. Silibinin Targeting Heat Shock Protein 90 Represents a Novel Approach to Alleviate Nonalcoholic Fatty Liver Disease by Simultaneously Lowering Hepatic Lipotoxicity and Enhancing Gut Barrier Function 419. beta-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization 420. Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer 421. CDKL3 is a targetable regulator of cell cycle progression in cancers 422. PIM1/NF-kappaB/CCL2 blockade enhances anti-PD-1 therapy response by modulating macrophage infiltration and polarization in tumor microenvironment of NSCLC 423. Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery 424. Therapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis 425. ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis 426. USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1 427. The Aggregation of alpha-Synuclein in the Dorsomedial Striatum Significantly Impairs Cognitive Flexibility in Parkinson's Disease Mice 428. Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus 429. Triggering Receptor Expressed on Myeloid Cells 2 Alleviated Sevoflurane-Induced Developmental Neurotoxicity via Microglial Pruning of Dendritic Spines in the CA1 Region of the Hippocampus 430. Eucommia ulmoidesOliv. leaves flavonoids attenuate methylglyoxal‐induced endothelial cell apoptosis in vitro and in vivo by upregulating AKT‐Nrf2 signaling and downregulating oxidative stress 431. Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke 432. Bilateral diffuse alveolar damage contributes to the fatal toxicity of pre-existing interstitial lung disease mice after partial thoracic irradiation 433. A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2 434. LCZ696, an angiotensin receptor-neprilysin inhibitor, ameliorates epithelial-mesenchymal transition of peritoneal mesothelial cells and M2 macrophage polarization 435. Astrocytic Nrf2 modulates microglial phagocytosis in environmental pollution-induced depressive-like mice 436. Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration 437. Lacidophilin Modulated Gut Microbiota and Ameliorated Dextran Sulfate Sodium-Induced Mouse Colitis 438. Increased intestinal permeability and lipopolysaccharide contribute to swainsonine-induced systemic inflammation 439. The link between neutrophils, NETs, and NLRP3 inflammasomes: The dual effect of CD177 and its therapeutic potential in acute respiratory distress syndrome/acute lung injury 440. CTDSPL2 promotes the progression of non-small lung cancer through PI3K/AKT signaling via JAK1 441. Hippocampal HDAC5-mediated histone acetylation underlies stress susceptibility in mice exposed to chronic social defeat stress 442. The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression 443. beta-Caryophyllene Confers Cardioprotection by Scavenging Radicals and Blocking Ferroptosis 444. Synergistic intravesical instillation for bladder cancer: CRISPR-Cas13a and fenbendazole combination therapy 445. The role of gut microbiota in chronic restraint stress-induced cognitive deficits in mice 446. Unraveling Cross-Organ Impacts of Airborne Pollutants: A Multiomics Study on Respiratory Exposure and Gastrointestinal Health 447. Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage 448. LINC00460/miR-186-3p/MYC feedback loop facilitates colorectal cancer immune escape by enhancing CD47 and PD-L1 expressions 449. Mechanism of Chaihuang-Yishen formula to attenuate renal fibrosis in the treatment of chronic kidney disease: Insights from network pharmacology and experimental validation 450. Identification of hub modules and therapeutic targets associated with CD8(+)T-cells in HF and their pan-cancer analysis 451. ML335 inhibits TWIK2 channel-mediated potassium efflux and attenuates mitochondrial damage in MSU crystal-induced inflammation 452. A Knitted and MXenzyme-Integrated Dressing for Geriatrics Diagnosis and Ulcer Healing 453. Identification of Isoliensinine as a Ferroptosis Suppressor with Iron-Chelating Activity 454. The role of mitochondrial autophagy in osteoarthritis 455. Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation 456. Far-infrared radiation alleviates steatohepatitis and fibrosis in metabolic dysfunction-associated fatty liver disease 457. Chlorella pyrenoidosa ameliorates ulcerative colitis by tuning intestinal microecology: Butyric acid is a crucial player 458. Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis 459. Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency 460. Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity 461. Regulatory effect of rapamycin on recruitment and function of myeloid-derived suppressor cells in heart failure 462. Modulating Elasticity of Liposome for Enhanced Cancer Immunotherapy 463. ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4(+) macrophage infiltration 464. Low doses of acetyl trihexyl citrate plasticizer promote adipogenesis in hepatocytes and mice 465. Intergenerational metabolism-disrupting effects of maternal exposure to plasticizer acetyl tributyl citrate (ATBC)466. CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism 467. IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration 468. Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice 469. Lipid synthesis, triggered by PPARgamma T166 dephosphorylation, sustains reparative function of macrophages during tissue repair 470. VSV infection and LPS treatment alter serum bile acid profiles.471. Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases 472. Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics 473. Comparison of antigen-specific B cell responses reveals disparity in immunogenicity and memory B cell formation across COVID-19 vaccine platforms 474. Discovery and evaluation of a novel 18F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity 475. Isolation and Characterization of Novel Escherichia coli O157:H7 Phage SPEC13 as a Therapeutic Agent for E. coli Infections In Vitro and In Vivo 476. GLT‐1 downregulation in hippocampal astrocytes induced by type 2 diabetes contributes to postoperative cognitive dysfunction in adult mice 477. Long-term exposure to polystyrene microplastics reduces macrophages and affects the microbiota–gut–brain axis in mice 478. Enhanced interaction between genome-edited mesenchymal stem cells and platelets improves wound healing in mice 479. Microbial-derived Urolithin A Targets GLS1 to Inhibit Glutaminolysis and Attenuate Cirrhotic Portal Hypertension 480. c-Myc alone is enough to reprogram fibroblasts into functional macrophages 481. Exploring the therapeutic potential of Bifidobacterium longum subsp. longum CCFM1029 in Parkinson's disease: Insights from behavioral, neurophysiological, gut microbiota, and microbial metabolites analysis 482. Short-term respiratory cadmium exposure partially activates pulmonary NLRP3 inflammasome by inducing ferroptosis in mice 483. Anti-tumor effects of nanosecond pulsed electric fields in a murine model of pancreatic cancer 484. Electroacupuncture reduces inflammatory damage following cerebral ischemia–reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia 485. Metabolic Profiling of Cochlear Organoids Identifies α‐Ketoglutarate and NAD+ as Limiting Factors for Hair Cell Reprogramming 486. Insulin-like growth factor-2 mRNA-binding protein 2 facilitates post-ischemic angiogenesis by increasing the stability of fibroblast growth factor 2 mRNA and its protein expression 487. Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis 488. Capture of RNA-binding proteins across mouse tissues using HARD-AP 489. Nicotinamide mononucleotide enhances fracture healing by promoting skeletal stem cell proliferation 490. The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis 491. Childhood anaesthesia and autism risk: population and murine study 492. Rhodium nanozyme mitigates RPE degeneration and preserves vision in age-related macular degeneration via antioxidant and anti-inflammatory mechanisms 493. Enhancing diabetic foot ulcer healing: Impact of the regulation of the FUS and ILF2 RNA‑binding proteins through negative pressure wound therapy 494. Lonicerin attenuates high-fat diet-induced hepatic steatosis through modulation of the gut microbiota-bile acid-FXR axis in mice 495. Inulin does not affect trimethylamine N‐oxide formation in mice with a high‐fat diet combined with choline and L‐carnitine 496. A multifunctional targeted nano-delivery system with radiosensitization and immune activation in glioblastoma 497. Small GTP-binding protein GDP dissociation stimulator influences cisplatin-induced acute kidney injury via PERK-dependent ER stress 498. Liver mechanosignaling as a natural anti-hepatitis B virus mechanism 499. Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice 500. Ellagic acid-enhanced biocompatibility and bioactivity in multilayer core-shell gold nanoparticles for ameliorating myocardial infarction injury 501. Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 bglap–bglap2 Deficiency Mouse Model 502. ZIKV induces P62-mediated autophagic degradation of TRAF6 through TRAF6-NS1 interaction 503. Single-cell RNA sequencing highlights the immunosuppression of IDO1+ macrophages in the malignant transformation of oral leukoplakia 504. Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis 505. Daucosterol alleviates heart failure with preserved ejection fraction through activating PPARα pathway 506. Branched‐Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel 507. Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I 508. DNA Methylation-Mediated GPX4 Transcriptional Repression and Osteoblast Ferroptosis Promote Titanium Particle-Induced Osteolysis 509. Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing 510. The Spermine Oxidase/Spermine Axis Coordinates ATG5-Mediated Autophagy to Orchestrate Renal Senescence and Fibrosis 511. Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells 512. Modulating amacrine cell–derived dopamine signaling promotes optic nerve regeneration and preserves visual function 513. YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer 514. DAP3 promotes mitochondrial activity and tumour progression in hepatocellular carcinoma by regulating MT-ND5 expression 515. Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC 516. Targeting tumor-associated macrophage-derived CD74 improves efficacy of neoadjuvant chemotherapy in combination with PD-1 blockade for cervical cancer 517. Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum 518. Crystalline silica-induced recruitment and immuno-imbalance of CD4(+) tissue resident memory T cells promote silicosis progression 519. Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity 520. Gasdermin D-mediated metabolic crosstalk promotes tissue repair 521. Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway 522. Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation 523. Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis 524. Identification and validation of a novel gene ARVCF associated with alcohol dependence among Chinese population 525. Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice 526. EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection 527. Local administration of mRNA encoding cytokine cocktail confers potent anti-tumor immunity 528. Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy 529. METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma 530. Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression 531. ACSL6-activated IL-18R1–NF-κB promotes IL-18–mediated tumor immune evasion and tumor progression.532. Enhanced tumor targeting and penetration of fluorophores via iRGD peptide conjugation: a strategy for the precision targeting of lung cancer 533. A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues 534. NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice 535. Mitochondrial modulation treating postoperative cognitive dysfunction neuroprotection via DRP1 inhibition by Mdivi1 536. Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits 537. The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning 538. Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty 539. Tilianin attenuates inflammasome activation in endothelial progenitor cells to mitigate myocardial ischemia-reperfusion injury 540. DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1 541. The gut microbiome in patients with Cushing's disease affects depression-and anxiety-like behavior in mice 542. Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond 543. TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet's disease 544. Gasdermin D promotes development of intestinal tumors through regulating IL-1β release and gut microbiota composition 545. Co-inhibition of PGF and VEGFA enhances the effectiveness of immunotherapy in bladder cancer 546. Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function 547. Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma 548. A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice 549. Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion 550. EGCG protects intestines of mice and pelvic cancer patients against radiation injury via the gut microbiota/D-tagatose/AMPK axis 551. Social isolation promotes tumor immune evasion via β2-adrenergic receptor 552. Pharmacological Inhibition of Phosphoglycerate Kinase 1 Reduces OxiDative Stress and Restores Impaired Autophagy in Experimental Acute Pancreatitis 553. Dihydro‐resveratrol ameliorates NLRP3 inflammasome‐mediated neuroinflammation via Bnip3‐dependent mitophagy in Alzheimer's disease 554. Acetate supplementation improves neurological outcomes by preventing hyperglycemia and suppressing Serpina3n expression in CA1 region after cardiac arrest and cardiopulmonary resuscitation 555. Ginsenoside Rb1 Alleviates DSS-Induced Ulcerative Colitis by Protecting the Intestinal Barrier Through the Signal Network of VDR, PPARγ and NF-κB 556. Odoratin balances ROS/NO through EZH2/PPARγ signalling to improve myocardial fibrosis 557. Tanyu Tongzhi formula attenuates atherosclerotic plaque vulnerability by inhibiting CD40+ monocyte differentiation 558. Decrease of Prolylcarboxypeptidase Dose of Aqueous Humor is Involved in the Pathogenesis of Primary Open-Angle Glaucoma via Finetuning of the Local Ocular Renin-Angiotensin System 559. Butyrate Inhibits the HDAC8/NF-κB Pathway to Enhance Slc26a3 Expression and Improve the Intestinal Epithelial Barrier to Relieve Colitis 560. Autophagy activation ameliorates the fibrosis of trabecular meshwork cells induced by TGFβ2 through the promotion of fibrotic proteins degradation 561. Theta-burst transcranial magnetic stimulation attenuates chronic ischemic demyelination and vascular cognitive impairment in mice 562. The gut microbiotas with metabolites regulate the protective role of miR-30a-5p in myocardial infarction 563. Identification of KW-2449 as a dual inhibitor of ferroptosis and necroptosis reveals that autophagy is a targetable pathway for necroptosis inhibitors to prevent ferroptosis 564. Hsa_circ_0004194 suppresses colorectal cancer progression via hsa-miR-27a-3p 565. Distinct effects of physical and functional ablation of brown adipose tissue on T3-dependent pathological cardiac remodeling 566. A bispecific antibody targeting the Ig domains of Siglec-E displays enhanced antitumor effects 567. Scutellarin alleviated ulcerative colitis through gut microbiota-mediated cAMP/PKA/NF-κB pathway 568. Impaired cardiomyocytes accelerate cardiac hypertrophy and fibrosis by delivering exosomes containing Shh/N-Shh/Gli1 in angiotensin II infused mice 569. Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice 570. Dual genes manipulation enhanced chemotherapy potentiates antitumor immunity based on extracellular vesicle system for glioblastoma treatment 571. Therapeutic Suppression of Atherosclerotic Burden and Vulnerability via Dll4 Inhibition in Plaque Macrophages Using Dual-Targeted Liposomes 572. Low-intensity pulsed ultrasound improves metabolic dysregulation in obese mice by suppressing inflammation and extracellular matrix remodeling 573. Carnosic acid ameliorates postinflammatory hyperpigmentation by inhibiting inflammatory reaction and melanin deposition 574. Characterization and analysis of extracellular vesicle-derived miRNAs from different adipose tissues in mice 575. ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis‐Associated Hepatocellular Carcinoma by Modulating Tumor‐Associated Macrophages 576. Gut microbiota of miR‐30a‐5p‐deleted mice aggravate high‐fat diet‐induced hepatic steatosis by regulating arachidonic acid metabolic pathway 577. Microbiome-induced reprogramming in post-transcriptional landscape using nanopore direct RNA sequencing 578. Britannin inhibits hepatocellular carcinoma development and metastasis through the GSK-3β/β-catenin signaling pathway 579. S-ketamine alleviates depression-like behavior and hippocampal neuroplasticity in the offspring of mice that experience prenatal stress 580. Targeting G-quadruplex by TMPyP4 for inhibition of colorectal cancer through cell cycle arrest and boosting anti-tumor immunity 581. Leupaxin promotes hepatic gluconeogenesis and glucose metabolism by coactivation with hepatic nuclear factor 4α 582. TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla 583. Probiotic-derived extracellular vesicles alleviate AFB1-induced intestinal injury by modulating the gut microbiota and AHR activation 584. 1, 25 (OH) 2D3 promotes insulin secretion through the classical pyroptosis pathway in vitro and vivo 585. Integrated bioinformatics analysis and in vivo validation of potential immune-related genes linked to diabetic nephropathy 586. Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer 587. Qingke Pingchuan granules alleviate airway inflammation in COPD exacerbation by inhibiting neutrophil extracellular traps in mice 588. Systemic tumor regression with synergy therapy: radiotherapy and CAR-T 589. Sestrin2 balances mitophagy and apoptosis through the PINK1-Parkin pathway to attenuate severe acute pancreatitis 590. Visualizing ER-phagy and ER architecture in vivo 591. Orbitofrontal control of the olfactory cortex regulates olfactory discrimination learning 592. Hypercapnia promotes NLRP3 inflammasome activation in microglia by activating P2X7R after lipopolysaccharide-induced activation of the TLR4/NF-κB signaling …593. Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE 594. PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF–caspase 8–GSDMD/E axis in ovarian cancer 595. WNT7B promotes cancer progression via WNT/β-catenin signaling pathway and predicts a poor prognosis in oral squamous cell carcinoma 596. Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating ERK1/2 …597. Helicobacter pylori promotes gastric cancer progression by activating the TGF-β/Smad2/EMT pathway through HKDC1 598. The Ketogenic Diet Modulates Tumor-Associated Neutrophil Polarization via the AMOT-YAP/TAZ Axis to Inhibit Colorectal Cancer Progression 599. Peptostreptococcus Anaerobius enhances dextran sulfate sodium-induced colitis by promoting nf-κB-NLRP3-Dependent macrophage pyroptosis 600. Wogonin mitigates microglia-mediated synaptic over-pruning and cognitive impairment following epilepsy 601. Mouse Bladder Smooth Muscle Lack the Functional Active NMDAR 602. Lipocalin-2 promotes CKD vascular calcification by aggravating VSMCs ferroptosis through NCOA4/FTH1-mediated ferritinophagy 603. F2RL1 Inhibition Alleviates Lipotoxicity-Induced Kidney Injury Through the Hippo Pathway in Diabetic Kidney Disease 604. Fast and sensitive multivalent spatial pattern-recognition for circular RNA detection 605. A synthetic peptide, derived from neurotoxin GsMTx4, acts as a non-opioid analgesic to alleviate mechanical and neuropathic pain through the TRPV4 channel 606. Segetalin B Promotes Bone Formation in Ovariectomized Mice by Activating PLD1/SIRT1 Signaling to Inhibit γ-Secretase-Mediated Notch1 Overactivation 607. Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming 608. Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNVIP neurons 609. Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis 610. WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration 611. Mechanism of S100A9-mediated astrocyte activation via TLR4/NF-κB in Parkinson's disease 612. MSAB limits osteoarthritis development and progression through inhibition of β-catenin-DDR2 signaling 613. Characterization and Role of Glucagon-Like Peptide 1 Receptor in the Lacrimal Gland: Novel Insights into Diabetic Dry Eye Pathogenesis 614. Tachykinin signaling in the right parabrachial nucleus mediates early-phase neuropathic pain development 615. Ammonium Sensing Patch with Ultrawide Linear Range and Eliminated Interference for Universal Body Fluids Analysis 616. Intermittent Social Isolation Enhances Social Investigation but Impairs Social Memory in Adult Male Mice 617. Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway 618. PKM2 is a key factor to regulate neurogenesis and cognition by controlling lactate homeostasis 619. LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer 620. Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes 621. Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis 622. Polydatin-Mediated Inhibition of HSP90α Disrupts NLRP3 Complexes and Alleviates Acute Pancreatitis 623. Exploring the clinical significance of TPX2 in pancreatic cancer: from biomarker to immunotherapy 624. Disulfidptosis and Its Hub Gene Slc3a2 Involved in Ulcerative Colitis Pathogenesis, Disease Progression, and Patient Responses to Biologic Therapies 625. Drug-Induced Senescence of Donor Dermal Fibroblasts Enhances Revascularization and Graft Success in Skin Transplantation 626. Role of m6A methyltransferase METTL3 in Keratoconus pathogenesis 627. PIEZO1 activation enhances myogenesis and mitigates muscle degeneration in rotator cuff tear 628. Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis 629. Rosthornin B alleviates inflammatory diseases via directly targeting NLRP3 630. Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios 631. Reciprocal tumor-platelet interaction through the EPHB1-EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma 632. Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy 633. Asymmetric dynamics of GABAergic system and paradoxical responses of GABAergic neurons in piriform seizures 634. Maternal gut microbiota influence stem cell function in offspring 635. Dietary inulin ameliorates obesity-induced severe acute pancreatitis via gut-pancreas axis 636. Hyperoside attenuates sepsis-induced acute lung injury by Nrf2 activation and ferroptosis inhibition 637. Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production 638. Cryoablation-induced neutrophil Ca2+ elevation and NET formation exacerbate immune escape in colorectal cancer liver metastasis 639. Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease 640. RRM2 Regulates Hepatocellular Carcinoma Progression Through Activation of TGF-β/Smad Signaling and Hepatitis B Virus Transcription 641. Dynamic Diselenide Hydrogels for Controlled Tumor Organoid Culture and Dendritic Cell Vaccination 642. Integrative Analysis Identifies NSUN2 as an Essential Coordinator for Glioma Malignancy and Glucose Metabolism 643. Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas 644. β-Hydroxybutyrate suppresses M1 macrophage polarization through β-hydroxybutyrylation of the STAT1 protein 645. Lactiplantibacillusplantarum HM-P2 influences gestational gut microbiome and microbial metabolism 646. Therapeutic Potential of IL‐37 in Cervical Cancer: Suppression of Tumour Progression and Enhancement of CD47‐Mediated Macrophage Phagocytosis 647. Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy 648. OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice 649. The mesenteric adipokine SFRP5 alleviated intestinal epithelial apoptosis improving barrier dysfunction in Crohn's disease 650. An anti-RAGE chimeric antibody alleviates CCl4-induced liver fibrosis via RAGE/NF-kB pathway in mice 651. STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation 652. Succinate Regulates Exercise‐Induced Muscle Remodelling by Boosting Satellite Cell Differentiation Through Succinate Receptor 1 653. TTK Inhibition Alleviates Postinjury Neointimal Formation and Atherosclerosis 654. Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis 655. Helicobacter Pylori-induced BRD2 m6A modification sensitizes gastric cancer cells to chemotherapy by breaking FLIP/Caspase-8 homeostasis 656. All-trans Retinoic Acid Sensitizes Epithelial Ovarian Cancer to PARP Inhibition after Exposure to Cisplatin 657. OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment 658. A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor 659. TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3,-5 660. Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells 661. Chemical activation of mitochondrial ClpP to modulate energy metabolism of CD4+ T cell for inflammatory bowel diseases treatment 662. Gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage 663. Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis 664. Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance 665. SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence 666. Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and …667. Phloretin attenuates inflammation induced by subarachnoid hemorrhage through regulation of the TLR2/MyD88/NF-kB pathway 668. Tetrandrine induces muscle atrophy involving ROS-mediated inhibition of Akt and FoxO3 669. Postbiotics From Lactobacillus Johnsonii Activates Gut Innate Immunity to Mitigate Alcohol‐Associated Liver Disease 670. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease 671. Preclinical Evaluation on Human Platelet Lysate for the Treatment of Secondary Injury Following Intracerebral Hemorrhage 672. An Integrative Approach for Imaging and Quantitative Analysis of Gut Microbiota Growth In Vivo Using Fluorescent D-Amino Acid Labeling and Fluorescence In Situ …673. NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice 674. Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice 675. Knockout of TMEM206 in mice associated with a loss of corneal transparency 676. Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p/CXCL1 axis 677. Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy 678. Loss of DNA Polymerase β Delays Atherosclerosis in ApoE−/− Mice Due to Inhibition of Vascular Smooth Muscle Cell Migration 679. rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis 680. STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia 681. Transient HR enhancement by RAD51-stimulatory compound confers protection on intestinal rather than hematopoietic tissue against irradiation in mice 682. Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury 683. Oral Astragalus polysaccharide alleviates adenine-induced kidney injury by regulating gut microbiota–short-chain fatty acids–kidney G protein-coupled receptors axis 684. Bisphenol B Exposure Promotes Melanoma Progression via Dysregulation of Lipid Metabolism in C57BL/6J Mice 685. Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids 686. CRISPR/CasRx-mediated RNA knockdown targeting β-catenin and Ihh signaling alleviates osteoarthritis 687. Inhibition of PCSK9 Protects against Cerebral Ischemia‒Reperfusion Injury via Attenuating Microcirculatory Dysfunction 688. Identifying and validating the key regulatory transcription factor YY1 in the aging process of pancreatic beta cells based on bioinformatics 689. Comparative investigation of metabolite signatures and hypoadiposity effect between Dali tea and Yunkang tea 690. Circulating Interleukin-6 Mediates PM2. 5-induced Ovarian Injury by Suppressing the PPARγ Pathway 691. CD137 Protein Expression Pattern Determines the Functional Role of Galectin‐9 in Colorectal Cancer 692. Donor Substitution Engineering of Hemicyanine Nanoparticles to Reprogram the Tumor Microenvironment and Enhance Fn14‐Targeted BiTE for Glioblastoma …693. Signature of Immune-Related Metabolic Genes Predicts the Prognosis of Hepatocellular Carcinoma 694. NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice 695. LDHA exacerbates myocardial ischemia-reperfusion injury through inducing NLRP3 lactylation 696. Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants 697. Klrb1 Loss Promotes Chronic Hepatic Inflammation and Metabolic Dysregulation 698. Upregulation of CD244 promotes CD8+ T cell exhaustion in patients with alveolar echinococcosis and a murine model 699. A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein 700. Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma 701. … microbiota and intestinal FXR siganlling involved in the alleviation of mulberry (Morus alba L.) leaf ethanol extract on type 2 diabetes mellitus in db/db mice 702. Testosterone deficiency aggravates diet-induced non-alcoholic fatty liver disease by inducing hepatocyte ferroptosis via targeting BMAL1 in mice 703. ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m6A-dependent manner after myocardial infarction 704. GSDMD Mediates Ang II-Induced Hypertensive Nephropathy by Regulating the GATA2/AQP4 Signaling Pathway 705. Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis 706. Knockout of TMEM206 in mice associated with a loss of corneal transparency 707. Suppression of intestinal Ticam1 ameliorated MASH via Akkermansia muciniphila QAA37749. 1 mediated betaine transformation 708. rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis 709. Testosterone deficiency aggravates diet-induced non-alcoholic fatty liver disease by inducing hepatocyte ferroptosis via targeting BMAL1 in mice 710. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease 711. Lactobacillus johnsonii Generates Cyclo(pro‐trp) and Promotes Intestinal Ca2+ Absorption to Alleviate CKD–SHPT 712. Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C 713. RvE1/ChemR23 facilitates hematoma clearance and promotes M2 polarization of macrophages/microglia in intracerebral hemorrhage 714. Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling 715. Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models 716. CircMRP4 orchestrates podocytes injury via the miR-499-5p/RRAGB/mTORC1 axis in diabetic kidney disease 717. Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice 718. Probiotic Limosilactobacillus reuteri DSM 17938 Alleviates Acute Liver Injury by Activating the AMPK Signaling via Gut Microbiota–Derived Propionate 719. METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway 720. The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in experimental severe asthma 721. CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1 722. Serpina3k lactylation protects from cardiac ischemia reperfusion injury 723. Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel 724. Protocol for extraction of gut interstitial fluid in mice with two-front nutrient supply 725. VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment 726. Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway 727. Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion 728. PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers 729. Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth 730. A Baicalin‐Based Functional Polymer in Dynamic Reversible Networks Alleviates Osteoarthritis by Cellular Interactions 731. Butyrolactone I blocks the transition of acute kidney injury to chronic kidney disease in mice by targeting JAK1 732. 4‐Octyl Itaconate Alleviates Myocardial Ischemia‐Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation 733. Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING‐Mediated Glycolysis 734. Electroacupuncture Pretreatment Reduces Ischemic Brain Injury by Inhibiting the Lactate Production and Its Derived Protein Lactylation Formation 735. Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease 736. Epigenetic regulation of cardiac tissue development by lysine lactylation 737. HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia 738. ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence 739. Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function 740. Peptide-drug conjugates repolarize glioblastoma-associated macrophages to resensitize chemo-immunotherapy of glioblastoma 741. Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration 742. A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification 743. ENTPD8 Overexpression Enhances Anti-PD-L1 Therapy in Hepatocellular Carcinoma via miR-214-5p Inhibition 744. Spatiotemporal landscape of kidney in a mouse model of hyperuricemia at single‐cell level 745. Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway 746. GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases 747. The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction 748. Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis 749. M6A Demethyltransferase FTO Attenuates Meniscus Degeneration and Osteoarthritis via Orchestrating Autophagy and Energetic Metabolism 750. Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation 751. Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis 752. Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity 753. A humanized anti-MSLN× 4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity 754. Redox-responsive metal-organic framework nanocapsules enhance tumor chemo-immunotherapy by modulating tumor metabolic reprogramming 755. Machine Learning‐Assisted High‐Throughput Screening of Nanozymes for Ulcerative Colitis 756. Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice 757. UVB Induces Sympathetic Nervous System Activation and Norepinephrine Secretion to Regulate The Skin Color of Mice Through the β2-AR/AP-1 Pathway in Epidermal Keratinocytes 758. Identification of Downregulated MECR Gene in Parkinson's Disease Through Integrated Transcriptomic Analysis and Validation 759. CA19-9-related macrophage polarization drives poor prognosis in HCC after immune checkpoint inhibitor treatment 760. Bioactive Glycyrrhizic Acid Ionic Liquid Self‐Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti‐Photoaging Signal Peptides 761. Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell–Cell Fusion and Immune Activation 762. Inulin improved endometrial ciliary damage caused by DEHP and nanoplastics co-exposure 763. MORF4L2 induces immunosuppressive microenvironment and immunotherapy resistance through GRHL2/MORF4L2/H4K12Ac/CSF1 axis in triple-negative breast cancer 764. Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice 765. Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut 766. E3 ligase RNF128 restricts A. alternata-induced ILC2 activation and type 2 immune response in the murine lung 767. Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis 768. The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma 769. The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity 770. Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses 771. Exosomes derived from fibroblasts in DFUs delay wound healing by delivering miR-93-5p to target macrophage ATG16L1 772. Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression 773. Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME “two-hit” in mice 774. FcRn-guided antigen trafficking enhances cancer vaccine efficacy 775. Exosome-equipped TNF antisense oligodeoxynucleotide or 2-deoxy-D-glucose ameliorated nonalcoholic steatohepatitis by modulating superoxide dismutase 1 in mice 776. Tigulixostat Alleviates Hyperuricemic Nephropathy by Promoting M2 Macrophage Polarization 777. Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway 778. Noradrenergic inputs from the locus coeruleus to anterior piriform cortex and the olfactory bulb modulate olfactory outputs 779. circSIRT2/miR‐542‐3p/VASH1 axis regulates endothelial‐to‐mesenchymal transition (EndMT) in subretinal fibrosis in age‐related macular degeneration models 780. MYSM1 attenuates osteoarthritis by recruiting PP2A to deubiquitinate and dephosphorylate RIPK2 781. Gut–liver translocation of pathogen Klebsiella pneumoniae promotes hepatocellular carcinoma in mice 782. Transcriptomics and Proteomics Analysis of the Liver of RAD52 Knockout Mice 783. Ultra-small quercetin-based nanotherapeutics ameliorate acute liver failure by combatting inflammation/cellular senescence cycle 784. USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis