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C57BL/6JGpt

Model: C57BL/6JGpt
Strain Number: N000013

Inbred strain

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt
Strain Number: N000013
Official Symbol: /
Strain Strategy: Log in to read more
NCBI Number: /
Research Areas: Inbred line
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Inbred strain
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage-Myofibroblast Transition in Bladder Remodeling. Adv Healthc Mater (2023)2. Construction of a cross-species cell landscape at single-cell level. Nucleic Acids Res (2022)3. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nat Nanotechnol (2022)4. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. SCIENCE ADVANCES (2022)5. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Cell Mol Immunol (2022)6. Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver. Cell Immunol (2022)7. Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway. Bioengineered (2022)8. Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation. Acta Pharmaceutica Sinica B (2021)9. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Science Advances (2022)10. IL‐36γ and IL‐36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress‐Induced Cell Death. Advanced Science (2021)11. Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies. Redox Biology (2021)12. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics. Acta Pharmaceutica Sinica B (2021)13. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice. Acta Pharmaceutica Sinica B (2021)14. ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer. Journal for ImmunoTherapy of Cancer (2021)15. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity. Theranostics (2021)16. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease. Theranostics (2021)17. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. Journal of Hematology & Oncology (2021)18. Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer. Nature Immunology (2021)19. Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy. Advanced Functional Materials (2020)20. PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery. Autophagy (2020)21. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Advanced Science (2020)22. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell Metabolism (2021)23. N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression. Molecular Cell (2021)24. Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury. EBioMedicine (2022)25. CD11b(+) CD43(hi) Ly6C(lo) splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis. Hepatology (2022)26. Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease. International Journal of Biological Sciences (2022)27. MAP7D2 reduces CD8(+) cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer. Molecular Therapy (2022)28. Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice. Aging Cell (2022)29. The m(6)A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell (2022)30. α-D-1,3-glucan from Radix Puerariae thomsonii improves NAFLD by regulating the intestinal flora and metabolites. Carbohydrate Polymers (2022)31. Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov (2022)32. Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis. Experimental & Molecular Medicine (2022)33. TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma. Journal of Clinical Investigation (2022)34. Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation. J Immunother Cancer (2022)35. Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route. Sci Total Environ (2022)36. Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun (2022)37. Single cell sequencing reveals that CD39 inhibition mediates changes to the tumor microenvironment. Nat Commun (2022)38. Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice. Nat Commun (2022)39. Long-term cadmium exposure impairs cognitive function by activating lnc-Gm10532/m6A/FIS1 axis-mediated mitochondrial fission and dysfunction. Sci Total Environ (2022)40. Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice. Diabetologia (2022)41. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells. Adv Sci (Weinh) (2022)42. Use of intercellular proximity labeling to quantify and decipher cell-cell interactions directed by diversified molecular pairs. Adv Sci (2022)43. Macrophage GSK3beta-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy. J Immunother Cancer (2022)44. Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFbeta2/ALK1 axis. Exp Mol Med (2022)45. FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury. Signal Transduct Target Ther (2022)46. Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction. Mol Ther Nucleic Acids (2023)47. Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis. Adv Sci (Weinh) (2022)48. Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice. Military Medical Research (2023)49. FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Nature Communications (2023)50. Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis. Nature Communications (2023)51. Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis. PHARMACOLOGICAL RESEARCH (2023)52. Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression. Acta Pharmaceutica Sinica B (2023)53. G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes. Acta Pharmaceutica Sinica B (2023)54. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. Acta Pharmaceutica Sinica B (2023)55. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction. Bioactive Materials (2023)56. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses. EMBO Mol Med (2023)57. PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy. International Journal of Biological Sciences (2023)58. PES1 reduces CD8(+) T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma. Journal of Biomedical Science (2023)59. Bioabsorbable nano-micelle hybridized hydrogel scaffold prevents postoperative melanoma recurrence. Journal of Controlled Release (2023)60. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism. Nature Communications (2023)61. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer. J Immunother Cancer (2023)62. Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice. Int J Biol Sci (2023)63. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice. Nat Commun (2023)64. Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer. Journal of Pharmaceutical Analysis (2023)65. The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway. NPJ Regen Med (2023)66. Upregulation of beta-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain. Bone Res (2023)67. Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury. Adv Sci (2023)68. C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape. Int J Biol Sci (2023)69. Design of a novel chimeric peptide via dual blockade of CD47/SIRPalpha and PD-1/PD-L1 for cancer immunotherapy. Sci China Life Sci (2023)70. Dysregulated Gln-Glu-alpha-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage. Cell Rep Med (2023)71. Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis. J Adv Res (2023)72. Malic Enzyme 1 as a Novel Anti-Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury. Adv Sci (2023)73. beta-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice. Redox Biol (2023)74. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma. J Exp Clin Cancer Res (2023)75. Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca(2+) overload. Redox Biol (2023)76. Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice. J Biomed Sci (2023)77. Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice. Redox Biol (2023)78. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes. Nat Cell Biol (2023)79. The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma. Adv Sci (2023)80. Zoledronic acid and thymosin alpha1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells. J Immunother Cancer (2023)81. Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils. Bioengineering & Translational Medicine (2023)82. Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells. Int J Biol Sci (2023)83. Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy. J Cachexia Sarcopenia Muscle (2023)84. The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice. Nat Commun (2023)85. Chronic stress accelerates glioblastoma progression via DRD2/ERK/beta-catenin axis and Dopamine/ERK/TH positive feedback loop. J Exp Clin Cancer Res (2023)86. Flavonoid Derivative DMXAA Attenuates Cisplatin-induced Acute Kidney Injury Independent of STING Signaling. CLINICAL SCIENCE (2023)87. Vimentin affects inflammation and neutrophil recruitment in airway epithelium during Streptococcus suis serotype 2 infection. VETERINARY RESEARCH (2023)88. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke. Cell Reports (2023)89. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. BMC Med (2023)90. RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A. Molecular Therapy-Nucleic Acids (2021)91. Administration of AG490 decreases the senescence of umbilical cord-mesenchymal stem cells and promotes the cytotherapeutic effect in liver fibrosis. Cell Death Discov (2023)92. Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides. Nat Commun (2023)93. Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy. Nat Commun (2023)94. Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer. Bioact Mater (2023)95. Development and Validation of Robust Ferroptosis-Related Genes in Myocardial Ischemia-Reperfusion Injury. J Cardiovasc Dev Dis (2023)96. Intravesical chemotherapy synergize with an immune adjuvant by a thermo-sensitive hydrogel system for bladder cancer. Bioact Mater (2024)97. Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway. Redox Rep (2023)98. Microglia sense and suppress epileptic neuronal hyperexcitability. Pharmacol Res (2023)99. Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast. Int J Radiat Oncol Biol Phys (2023)100. Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization. Sci Rep (2023)101. PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1. Cancer Sci (2023)102. Pomegranate-derived exosome-like nanovesicles ameliorate high-fat diet-induced nonalcoholic fatty liver disease via alleviating mitochondrial dysfunction. Journal of Functional Foods (2023)103. PPARalpha/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach. Environ Int (2023)104. Sandwich-Structured Implants to Obstruct Multipath Energy Supply and Trigger Self-Enhanced Hypoxia-Initiated Chemotherapy Against Postsurgical Tumor Recurrence and Metastasis. Adv Sci (2023)105. Multi-omics reveals aspirin eugenol ester alleviates neurological disease. Biomed Pharmacother (2023)106. Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes. iScience (2023)107. C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome. Life Sci (2022)108. Antigen priming induces functional reprogramming in iNKT cells via metabolic and epigenetic regulation An insight into iNKT cell-based anti-tumor immunotherapy. Cancer Immunol Res (2023)109. Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration. JHEP Reports (2023)110. DOCK8 inhibits the immune function of neutrophils in sepsis by regulating aerobic glycolysis. Immun Inflamm Dis (2023)111. Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy. J Transl Med (2023)112. Enteric fungi protect against intestinal ischemia-reperfusion injury via inhibiting the SAA1-GSDMD pathway. J Adv Res (2023)113. HIVEP3 inhibits fate decision of CD8+ invariant NKT cells after positive selection. J Leukoc Biol (2023)114. Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice. Biocell (2023)115. Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics. Gene (2023)116. J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-kappaB signaling pathway. J Mol Histol (2023)117. Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing. Biomater Res (2023)118. Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis. Adv Sci (2023)119. Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells. Signal Transduct Target Ther (2023)120. PC3T: a signature-driven predictor of chemical compounds for cellular transition. Commun Biol (2023)121. Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate. STAR Protoc (2023)122. Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors. J Transl Med (2023)123. Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin. Biomed Pharmacother (2023)124. Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria. Cell Rep (2023)125. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death Dis (2022)126. The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice. Cell Reports (2022)127. Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis. Burns Trauma (2023)128. Astragaloside IV Ameliorates Inflammatory Damage in Mice with Acute Liver Failure. Chinese Medicine (2023)129. Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling. Nat Commun (2023)130. CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis. Ren Fail (2023)131. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation. Nat Commun (2023)132. Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway. Drug Des Devel Ther (2023)133. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease. Cell Death Discov (2023)134. Engineered oncolytic bacteria HCS1 exerts high immune stimulation and safety profiles for cancer therapy. Theranostics (2023)135. Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100beta under high-altitude conditions. Mol Biomed (2023)136. Evaluation of time-dependent phenotypes of myocardial ischemia-reperfusion in mice. Aging-US (2023)137. GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure. Int J Med Sci (2023)138. HBV suppresses macrophage immune responses by impairing the TCA cycle through the induction of CS/PDHC hyperacetylation. Hepatol Commun (2023)139. Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis. Aging-US (2023)140. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal (2023)141. IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma. Nat Commun (2023)142. Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus-Angelica sinensis Codecoction. ACS Appl Mater Interfaces (2023)143. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity. Cell Rep (2023)144. Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer. Transl Oncol (2023)145. Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis. Cell Discov (2023)146. MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-kappaB pathway. Respir Res (2023)147. Novel cannabinoid receptor 1 inverse agonist CRB-913 enhances efficacy of tirzepatide, semaglutide, and liraglutidein the diet-induced obesity mouse model. Obesity (2023)148. Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine. Cell Rep Med (2023)149. Oxymatrine inhibits melanoma development by modulating the immune microenvironment and targeting the MYC/PD-L1 pathway. Int Immunopharmacol (2023)150. PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation. Gut Microbes (2023)151. Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress. Cell Death Dis (2023)152. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metab (2023)153. MircroRNA-92b as a negative regulator of the TGF-beta signaling by targeting the type I receptor. iScience (2023)154. Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression. Cell Metab (2022)155. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis. Eur J Pharmacol (2022)156. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1. Cell Mol Life Sci (2023)157. A single-cell transcriptomic atlas characterizes age-related changes of murine cranial stem cell niches. Aging Cell (2023)158. Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma. Mol Biomed (2023)159. Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes. International Journal of Medical Sciences (2024)160. Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma. J Exp Clin Cancer Res (2023)161. Costal Cartilage Graft Repair Osteochondral Defect in a Mouse Model. Cartilage (2023)162. Discovery of Zidovudine as a cardiomyocyte protectant for doxorubicin-induced toxicity through high-throughput phenotypic drug screening. Fundamental Research (2023)163. Does decreased autophagy and dysregulation of LC3A in astrocytes play a role in major depressive disorder?. Transl Psychiatry (2023)164. Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction. J Mol Cell Biol (2023)165. Hollow Cu2MoS4 nanoparticles loaded with immune checkpoint inhibitors reshape the tumor microenvironment to enhance immunotherapy for pancreatic cancer. Acta Biomater (2023)166. Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect. J Virol (2023)167. Interferon stimulated immune profile changes in a humanized mouse model of HBV infection. Nat Commun (2023)168. Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes. ACS Pharmacology & Translational Science (2023)169. Metabolomics study reveals increased deoxycholic acid contributes to deoxynivalenol-mediated intestinal barrier injury. Life Sci (2023)170. Mirabegron displays anticancer effects by globally browning adipose tissues. Nat Commun (2023)171. PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage. Journal of Integrative Neuroscience (2023)172. Protective effects of metformin on pancreatic beta-cell ferroptosis in type 2 diabetes in vivo. Biomed Pharmacother (2023)173. Temporal dynamics and composition of ocular surface microbiota in C57BL/6J mice: uncovering a 12h ultradian rhythm. Front Cell Infect Microbiol (2023)174. The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3–SRF axis. Acta Pharmaceutica Sinica B (2023)175. Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer. Genome Biol (2023)176. Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance. Nat Genet (2023)177. The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity. Cell Metab (2023)178. Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma. Clin Epigenetics (2023)179. A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection. Pharmacol Res (2023)180. Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway. Biomed Pharmacother (2023)181. Bile acid metabolomics identifies chenodeoxycholic acid as a therapeutic agent for pancreatic necrosis. Cell Rep Med (2023)182. Comprehensive Analysis of PANoptosis-Related Gene Signature of Ulcerative Colitis. International Journal of Molecular Sciences (2023)183. CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway. Heliyon (2024)184. Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling. Nat Commun (2023)185. Foxa2 attenuates steatosis and inhibits the NF-kappaB/IKK signaling pathway in nonalcoholic fatty liver disease. PeerJ (2023)186. Gut Microbial Diversity Analysis of Different Native Chickens and Screening of Chicken-Derived Probiotics. Animals (2023)187. Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation. SCIENCE ADVANCES (2023)188. Liver Regeneration-Related Genes of Nontumor Liver Tissues Predict the Prognosis of Patients with Hepatocellular Carcinoma. J Hepatocell Carcinoma (2023)189. Magnetic Metal-Organic Framework-Based Nanoplatform with Platelet Membrane Coating as a Synergistic Programmed Cell Death Protein 1 Inhibitor against Hepatocellular Carcinoma. ACS Nano (2023)190. MiR-192-5p Ameliorates Hepatic Lipid Metabolism in Non-Alcoholic Fatty Liver Disease by Targeting Yy1. Biomolecules (2023)191. Muscone ameliorates myocardial ischemia‒reperfusion injury by promoting myocardial glycolysis. Heliyon (2023)192. Retinoic acid-inducible gene-1 knockdown induces immature properties in dendritic cells and prolongs the survival time of allograft mice. Gene (2023)193. Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries. Antioxidants (2023)194. Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy. Gut (2023)195. Tetrahedral framework nucleic acid loaded with glabridin: A transdermal delivery system applicated to anti-hyperpigmentation. Cell Prolif (2023)196. Time-restricted feeding alleviates metabolic implications of circadian disruption by regulating gut hormone release and brown fat activation. Food Funct (2023)197. Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic beta-Cell Impairment. Exp Clin Endocrinol Diabetes (2023)198. Single-particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier. J Extracell Vesicles (2023)199. Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2. Acta Pharmaceutica Sinica B (2024)200. Extracellular vesicles released by transforming growth factor-beta 1-preconditional mesenchymal stem cells promote recovery in mice with spinal cord injury. Bioactive Materials (2024)201. Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis. Redox Biol (2024)202. Bioinformatic analysis and in vivo validation of angiogenesis related genes in inflammatory bowel disease.>. BIOCELL (2024)203. Si-Zhi Wan regulates osteoclast autophagy in osteoporosis through the AMPK signaling pathway to attenuate osteoclastogenesis. JOURNAL OF PHARMACY AND PHARMACOLOGY (2024)204. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Disease Models & Mechanisms (2024)205. LIM1863 is useful to explore collective cancer cell migration, and the group of heterogeneous cells undergoing collective migration behaves like a supracellular unit.. BIOCELL (2023)206. Biphasic calcium phosphate recruits Tregs to promote bone regeneration. Acta Biomater (2024)207. The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy-induced osteoporosis. Food Science & Nutrition (2024)208. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery. Aging Cell (2023)209. Jinfukang inhibits lung cancer metastasis by regulating T cell receptors. J Ethnopharmacol (2024)210. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging. Biomedicines (2024)211. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism. Advanced Science (2023)212. Identification and validation of key biomarkers associated with macrophages in nonalcoholic fatty liver disease based on hdWGCNA and machine learning. Aging-US (2024)213. Paternal preconceptional supplementation of n‐3 polyunsaturated fatty acids alleviates offspring nonalcoholic fatty liver disease in high‐fat diet‐induced obese mice. Food Frontiers (2024)214. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction. Mol Metab (2024)215. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson's disease. J Transl Med (2024)216. Hepatitis B virus-mediated sodium influx contributes to hepatic inflammation via synergism with intrahepatic danger signals. iScience (2024)217. MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning. Cell Biosci (2024)218. Knockdown of Slfn5 alleviates lipopolysaccharide-induced pneumonia by regulating Janus kinase/signal transduction and activator of transcription pathway. J Thorac Dis (2023)219. Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function. 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