C57BL/6JGpt

C57BL/6JGpt|Strain NO.N000013

Inbred strain

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt
Strain Number:	N000013
Official Symbol:
Strain Strategy:	N000013.C57BL_6JGpt strain info.pdf
Research Areas:	Inbred line
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Inbred strain
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage-Myofibroblast Transition in Bladder Remodeling 2. Natural Cell Patches: Melanin Nanoparticles for MR Imaging‐Guided Antiatherosclerosis Therapy via Attenuating Macrophage Pyroptosis 3. Construction of a cross-species cell landscape at single-cell level 4. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination 5. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4 6. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia 7. Methyl butyrate attenuates concanavalin A-induced autoimmune hepatitis by inhibiting Th1-cell activation and homing to the liver 8. Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway 9. Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation 10. Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism 11. IL‐36γ and IL‐36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress‐Induced Cell Death 12. Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies 13. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics 14. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice 15. ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer 16. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity 17. MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease 18. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors 19. Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer 20. Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy 21. PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery 22. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo 23. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity 24. N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression 25. Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury 26. CD11b(+) CD43(hi) Ly6C(lo) splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis 27. Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease 28. MAP7D2 reduces CD8(+) cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer 29. Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice 30. The m(6)A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia 31. α-D-1,3-glucan from Radix Puerariae thomsonii improves NAFLD by regulating the intestinal flora and metabolites 32. Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming 33. Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis 34. TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma 35. Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation 36. Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route 37. Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor 38. Single cell sequencing reveals that CD39 inhibition mediates changes to the tumor microenvironment 39. Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice 40. Long-term cadmium exposure impairs cognitive function by activating lnc-Gm10532/m6A/FIS1 axis-mediated mitochondrial fission and dysfunction 41. Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice 42. The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca(2+) -LRMDA Axis in Myeloid Cells 43. Use of intercellular proximity labeling to quantify and decipher cell-cell interactions directed by diversified molecular pairs 44. Macrophage GSK3beta-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy 45. Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFbeta2/ALK1 axis 46. FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury 47. Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction 48. Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis 49. Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice 50. FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke 51. Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis 52. Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis 53. Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression 54. G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes 55. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases 56. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction 57. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses 58. PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy 59. PES1 reduces CD8(+) T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma 60. Bioabsorbable nano-micelle hybridized hydrogel scaffold prevents postoperative melanoma recurrence 61. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism 62. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy 63. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer 64. Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice 65. Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice 66. Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer 67. The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway 68. Upregulation of beta-catenin signaling represents a single common pathway leading to the various phenotypes of spinal degeneration and pain 69. Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury 70. C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape 71. Design of a novel chimeric peptide via dual blockade of CD47/SIRPalpha and PD-1/PD-L1 for cancer immunotherapy 72. Dysregulated Gln-Glu-alpha-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage 73. Infusion of GMSCs relieves autoimmune arthritis by suppressing the externalization of neutrophil extracellular traps via PGE2-PKA-ERK axis 74. Malic Enzyme 1 as a Novel Anti-Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury 75. beta-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice 76. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma 77. Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca(2+) overload 78. Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice 79. Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice 80. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes 81. The Combination of R848 with Sorafenib Enhances Antitumor Effects by Reprogramming the Tumor Immune Microenvironment and Facilitating Vascular Normalization in Hepatocellular Carcinoma 82. Zoledronic acid and thymosin alpha1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells 83. Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils 84. Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells 85. Skeletal muscle-specific DJ-1 ablation-induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophy 86. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing 87. The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice 88. Chronic stress accelerates glioblastoma progression via DRD2/ERK/beta-catenin axis and Dopamine/ERK/TH positive feedback loop 89. Flavonoid Derivative DMXAA Attenuates Cisplatin-induced Acute Kidney Injury Independent of STING Signaling 90. Vimentin affects inflammation and neutrophil recruitment in airway epithelium during Streptococcus suis serotype 2 infection 91. Synaptotagmin-3 interactions with GluA2 mediate brain damage and impair functional recovery in stroke 92. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice 93. RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A 94. Administration of AG490 decreases the senescence of umbilical cord-mesenchymal stem cells and promotes the cytotherapeutic effect in liver fibrosis 95. Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides 96. Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy 97. Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer 98. Development and Validation of Robust Ferroptosis-Related Genes in Myocardial Ischemia-Reperfusion Injury 99. Intravesical chemotherapy synergize with an immune adjuvant by a thermo-sensitive hydrogel system for bladder cancer 100. Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway 101. Microglia sense and suppress epileptic neuronal hyperexcitability 102. Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast 103. Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization 104. PAX5 and circ1857 affected DLBCL progression and B-cell proliferation through regulating GINS1 105. Pomegranate-derived exosome-like nanovesicles ameliorate high-fat diet-induced nonalcoholic fatty liver disease via alleviating mitochondrial dysfunction 106. PPARalpha/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach 107. Sandwich-Structured Implants to Obstruct Multipath Energy Supply and Trigger Self-Enhanced Hypoxia-Initiated Chemotherapy Against Postsurgical Tumor Recurrence and Metastasis 108. Multi-omics reveals aspirin eugenol ester alleviates neurological disease 109. Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes 110. C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome 111. Antigen priming induces functional reprogramming in iNKT cells via metabolic and epigenetic regulation An insight into iNKT cell-based anti-tumor immunotherapy 112. Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration 113. DOCK8 inhibits the immune function of neutrophils in sepsis by regulating aerobic glycolysis 114. Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy 115. Enteric fungi protect against intestinal ischemia-reperfusion injury via inhibiting the SAA1-GSDMD pathway 116. HIVEP3 inhibits fate decision of CD8+ invariant NKT cells after positive selection 117. Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice 118. Identification and analysis of key genes in adipose tissue for human obesity based on bioinformatics 119. J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-kappaB signaling pathway 120. Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing 121. Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis 122. Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells 123. PC3T: a signature-driven predictor of chemical compounds for cellular transition 124. Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate 125. Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors 126. Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin 127. Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria 128. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages 129. The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice 130. Actin polymerization inhibition by targeting ARPC2 affects intestinal stem cell homeostasis 131. Astragaloside IV Ameliorates Inflammatory Damage in Mice with Acute Liver Failure 132. Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling 133. CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis 134. Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation 135. Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway 136. Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson's disease 137. Engineered oncolytic bacteria HCS1 exerts high immune stimulation and safety profiles for cancer therapy 138. Enteric glial cells aggravate the intestinal epithelial barrier damage by secreting S100beta under high-altitude conditions 139. Evaluation of time-dependent phenotypes of myocardial ischemia-reperfusion in mice 140. GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure 141. HBV suppresses macrophage immune responses by impairing the TCA cycle through the induction of CS/PDHC hyperacetylation 142. Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis 143. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis 144. IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma 145. Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus-Angelica sinensis Codecoction 146. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity 147. Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer 148. Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis 149. MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-kappaB pathway 150. Novel cannabinoid receptor 1 inverse agonist CRB-913 enhances efficacy of tirzepatide, semaglutide, and liraglutidein the diet-induced obesity mouse model 151. Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine 152. Oxymatrine inhibits melanoma development by modulating the immune microenvironment and targeting the MYC/PD-L1 pathway 153. PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation 154. Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress 155. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease 156. MircroRNA-92b as a negative regulator of the TGF-beta signaling by targeting the type I receptor 157. Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression 158. Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis 159. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1 160. A single-cell transcriptomic atlas characterizes age-related changes of murine cranial stem cell niches 161. Aloperine targets lysosomes to inhibit late autophagy and induces cell death through apoptosis and paraptosis in glioblastoma 162. Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes 163. Blockage of CacyBP inhibits macrophage recruitment and improves anti-PD-1 therapy in hepatocellular carcinoma 164. Costal Cartilage Graft Repair Osteochondral Defect in a Mouse Model 165. Discovery of Zidovudine as a cardiomyocyte protectant for doxorubicin-induced toxicity through high-throughput phenotypic drug screening 166. Does decreased autophagy and dysregulation of LC3A in astrocytes play a role in major depressive disorder?167. Group 3 Innate Lymphoid Cells Exacerbate Lupus Nephritis by Promoting B Cell Activation in Kidney Ectopic Lymphoid Structures 168. Highly efficient conversion of mouse fibroblasts into functional hepatic cells under chemical induction 169. Hollow Cu2MoS4 nanoparticles loaded with immune checkpoint inhibitors reshape the tumor microenvironment to enhance immunotherapy for pancreatic cancer 170. Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect 171. Interferon stimulated immune profile changes in a humanized mouse model of HBV infection 172. Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes 173. Metabolomics study reveals increased deoxycholic acid contributes to deoxynivalenol-mediated intestinal barrier injury 174. Mirabegron displays anticancer effects by globally browning adipose tissues 175. PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage 176. Protective effects of metformin on pancreatic beta-cell ferroptosis in type 2 diabetes in vivo 177. Temporal dynamics and composition of ocular surface microbiota in C57BL/6J mice: uncovering a 12h ultradian rhythm 178. The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3–SRF axis 179. Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer 180. Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance 181. The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity 182. Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma 183. A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection 184. Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway 185. Bile acid metabolomics identifies chenodeoxycholic acid as a therapeutic agent for pancreatic necrosis 186. Comprehensive Analysis of PANoptosis-Related Gene Signature of Ulcerative Colitis 187. CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway 188. Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling 189. Foxa2 attenuates steatosis and inhibits the NF-kappaB/IKK signaling pathway in nonalcoholic fatty liver disease 190. Gut Microbial Diversity Analysis of Different Native Chickens and Screening of Chicken-Derived Probiotics 191. Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation 192. Liver Regeneration-Related Genes of Nontumor Liver Tissues Predict the Prognosis of Patients with Hepatocellular Carcinoma 193. Magnetic Metal-Organic Framework-Based Nanoplatform with Platelet Membrane Coating as a Synergistic Programmed Cell Death Protein 1 Inhibitor against Hepatocellular Carcinoma 194. MiR-192-5p Ameliorates Hepatic Lipid Metabolism in Non-Alcoholic Fatty Liver Disease by Targeting Yy1 195. Muscone ameliorates myocardial ischemia‒reperfusion injury by promoting myocardial glycolysis 196. Retinoic acid-inducible gene-1 knockdown induces immature properties in dendritic cells and prolongs the survival time of allograft mice 197. Silibinin Inhibits Cell Ferroptosis and Ferroptosis-Related Tissue Injuries 198. Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy 199. Tetrahedral framework nucleic acid loaded with glabridin: A transdermal delivery system applicated to anti-hyperpigmentation 200. Time-restricted feeding alleviates metabolic implications of circadian disruption by regulating gut hormone release and brown fat activation 201. Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic beta-Cell Impairment 202. Single-particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier 203. Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2 204. Extracellular vesicles released by transforming growth factor-beta 1-preconditional mesenchymal stem cells promote recovery in mice with spinal cord injury 205. Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis 206. Bioinformatic analysis and in vivo validation of angiogenesis related genes in inflammatory bowel disease.>207. Si-Zhi Wan regulates osteoclast autophagy in osteoporosis through the AMPK signaling pathway to attenuate osteoclastogenesis 208. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response 209. LIM1863 is useful to explore collective cancer cell migration, and the group of heterogeneous cells undergoing collective migration behaves like a supracellular unit.210. Biphasic calcium phosphate recruits Tregs to promote bone regeneration 211. The supplementation of Rothia as a potential preventive approach for bone loss in mice with ovariectomy-induced osteoporosis 212. Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery 213. Jinfukang inhibits lung cancer metastasis by regulating T cell receptors 214. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging 215. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism 216. Identification and validation of key biomarkers associated with macrophages in nonalcoholic fatty liver disease based on hdWGCNA and machine learning 217. Paternal preconceptional supplementation of n‐3 polyunsaturated fatty acids alleviates offspring nonalcoholic fatty liver disease in high‐fat diet‐induced obese mice 218. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction 219. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson's disease 220. Hepatitis B virus-mediated sodium influx contributes to hepatic inflammation via synergism with intrahepatic danger signals 221. MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning 222. Knockdown of Slfn5 alleviates lipopolysaccharide-induced pneumonia by regulating Janus kinase/signal transduction and activator of transcription pathway 223. Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function 224. Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation.pdf 225. Inhibition of 15-hydroxyprostaglandin dehydrogenase protects neurons from ferroptosis in ischemic stroke 226. Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS 227. Enteral nutrition promotes the remission of colitis by gut bacteria-mediated histidine biosynthesis 228. BCG immunotherapy promotes tumor-derived T-cell activation through the FLT3/FLT3LG pathway in bladder cancer 229. Inhibition of Hyperglycemia and Hyperlipidemia by Blocking Toll-like Receptor 4: Comparison of Wild-Type and Toll-like Receptor 4 Gene Knockout Mice on Obesity and Diabetes Modeling 230. Neuromorphic electro-stimulation based on atomically thin semiconductor for damage-free inflammation inhibition 231. Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder 232. RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis 233. Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice 234. Bhlhe40 deficiency attenuates LPS-induced acute lung injury through preventing macrophage pyroptosis 235. Downregulation of the CD151 protects the cardiac function by the crosstalk between the endothelial cells and cardiomyocytes via exosomes 236. Bee Venom Stimulates Growth Factor Release from Adipose-Derived Stem Cells to Promote Hair Growth 237. Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL 238. Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity 239. Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration 240. Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis 241. High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures 242. TREM2 Alleviates Subarachnoid Hemorrhage-Induced Brain Injury through Attenuating Neuroinflammation and Programmed Cell Death in Vivo and in Vitro 243. P53 Alleviates the Progression of Periodontitis by Reducing M1-type Macrophage Differentiation 244. Melatonin improves cholestatic liver disease via the gut-liver axis 245. Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation 246. Low-Shear Stress Promotes Atherosclerosis via Inducing Endothelial Cell Pyroptosis Mediated by IKKepsilon/STAT1/NLRP3 Pathway 247. Targeted delivery of Fc-fused PD-L1 for effective management of acute and chronic colitis 248. Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function 249. Urban Particulate Matter Triggers Meibomian Gland Dysfunction