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Gpt:ICR

Mouse Model: ICR
Strain Number: N000294

Outbred

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: Gpt:ICR
Strain Number: N000294
Official Symbol: /
Strain Strategy: N000294.ICR strain info.pdf
NCBI Number: /
Research Areas: Distant line
Strain Background: [N000294] ICR/Gpt
Modification Type: Outbred
Inventory Status: Live
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Edible CaCO 3 nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation. Journal of nanobiotechnology (2021)2. X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3. PLoS genetics (2021)3. Using Liposomes to Alleviate the Toxicity of Chelerythrine, a Natural PKC Inhibitor, in Treating Non-Small Cell Lung Cancer. Frontiers in Oncology (2021)4. Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia. Haematologica (2021)5. Changes in the gut microbiota: a possible factor influencing peripheral blood immune indexes in non-obese diabetic mice. Antonie van Leeuwenhoek (2021)6. Limonin ameliorates acute pancreatitis by suppressing JAK2/STAT3 signaling pathway. Environmental Toxicology (2021)7. Tetrahedral Framework Nucleic Acids Reestablish Immune Tolerance and Restore Saliva Secretion in a Sjögren’s Syndrome Mouse Model. ACS Applied Materials & Interfaces (2021)8. miR-98-5p plays a critical role in depression and antidepressant effect of ketamine. Translational Psychiatry (2021)9. Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure. Environment International (2022)10. Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system. Experimental Neurology (2022)11. Targeting EZH2 prevents the occurrence and mitigates the development of Sjögren's syndrome in mice. International Immunopharmacology (2022)12. Hydrogen Sulfide Prevents LPS-Induced Depression-like Behavior through the Suppression of NLRP3 Inflammasome and Pyroptosis and the Improvement of Mitochondrial Function in the Hippocampus of Mice. Biology-basel (2023)13. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses (2023)14. Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting. Engineering (2024)15. Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research. Biomolecules (2024)16. Exploration on Application Effectiveness of Microbial Capture Filter Membranes from Different Materials in Barrier Environment Facilities. Laboratory Animal and Comparative Medicine (2024)17. Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing. International Journal of Molecular Sciences (2024)18. Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study. Journal of Functional Foods (2024)19. Combination of Astragalus-Salvia and Ophiopogon-Dendrobium herb pairs alleviates Sjögren’s Syndrome via inhibiting the JAK1/STAT3 and PI3K/AKT pathways in NOD/Ltj mice. Chinese Journal of Natural Medicines (2024)20. A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice. Nat Commun (2024)21. The synergistic effect of pulsed red light and leonurus inhibits primary dysmenorrhea induced by oxytocin in mice by modulating calcium signaling and inhibiting inflammatory responses. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2024)22. Salivary gland protective and antiinflammatory effects of genistein in Sjögren's syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha. Cell Mol Biol Lett (2024)23. Pulsed red light photobiomodulation ameliorates oxytocin-induced primary dysmenorrhea in mice by inhibiting oxidative stress and lipid accumulation. Journal of photochemistry and photobiology. (2025)24. Chemerin mediates exercise-induced improvements of bone microstructure and bone mass in diabetes or high fat diet mice. Molecular and cellular endocrinology (2025)25. S100PBP interacts with nucleoporin TPR and facilitates XY crossover formation in mice. EMBO Rep (2025)26. Spatiotemporal Adaptations-Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response. Adv Sci (Weinh) (2025)27. N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer's disease. Genes and immunity (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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