NOD/ShiLtJGpt

Model: NOD/ShiLtJGpt
Strain Number: N000235

Spontaneous Mutation,Inbred strain

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: NOD/ShiLtJGpt
Strain Number: N000235
Official Symbol: /,/
Strain Strategy: N000235.NOD_ShiLtJGpt strain Info .pdf
NCBI Number: //
Research Areas: Inbred line
Strain Background: [N000235] NOD/ShiLtJGpt
Modification Type: Spontaneous Mutation,Inbred strain
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Effect of Eriocalyxin B on prostatic inflammation and pelvic pain in a mouse model of experimental autoimmune prostatitis. The Prostate (2020)2. Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes. Acta Diabetologica (2021)3. The Effect of Immunosuppressive Adjuvant Kynurenine on Type 1 Diabetes Vaccine. Frontiers in Immunology (2021)4. Changes in the gut microbiota: a possible factor influencing peripheral blood immune indexes in non-obese diabetic mice. Antonie van Leeuwenhoek (2021)5. Tetrahedral Framework Nucleic Acids Reestablish Immune Tolerance and Restore Saliva Secretion in a Sjögren’s Syndrome Mouse Model. ACS Applied Materials & Interfaces (2021)6. PPAR-alpha Agonist Fenofibrate Ameliorates Sjogren Syndrome-Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice. Invest Ophthalmol Vis Sci (2022)7. PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis. Advances in Rheumatology (2022)8. Targeting EZH2 prevents the occurrence and mitigates the development of Sjögren's syndrome in mice. International Immunopharmacology (2022)9. Integrated DNA Methylation and Transcriptomics Analyses of Lacrimal Glands Identify the Potential Genes Implicated in the Development of Sjogren's Syndrome-Related Dry Eye. J Inflamm Res (2023)10. Effects of Extracellular Vesicles Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells on Cell Immunity in Nonobese Mice. Stem Cells International (2024)11. Combination of Astragalus-Salvia and Ophiopogon-Dendrobium herb pairs alleviates Sjögren’s Syndrome via inhibiting the JAK1/STAT3 and PI3K/AKT pathways in NOD/Ltj mice. Chinese Journal of Natural Medicines (2024)12. RERE-AS1 enhances the effect of CDK4/6 inhibitor Ribociclib and suppresses malignant phenotype in breast cancer via MEK/ERK pathway. J Transl Med (2024)13. S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sjögren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway. Investigative ophthalmology & visual science (2025)14. Dual targeting of Aurora Kinase A and poly (ADP-ribose) polymerase as a therapeutic option for patients with ovarian cancer: preclinical evaluations. J Cancer Res Clin Oncol (2025)15. HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells. Cell Oncol (Dordr) (2025)16. HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages. Journal of inflammation research (2025)17. Alterations in CD8+CD45RA+CCR7- T cells as a potential biomarker for primary Sjögren's syndrome. Immunobiology (2025)18. Exploring the role of diosgenin in modulating RUNX1 and HIPK2 transcription to mitigate Primary Sjögren's Syndrome. Immunobiology (2025)19. Prostaglandin F2α exacerbated dry eye by promoting lacrimal gland fibrosis progression through the activation of the RhoA/ROCKs signaling pathway. Ocul Surf (2025)20. Establishment of a mouse model of Sjögren syndrome-related interstitial lung disease. J Immunol (2025)21. Artemisinin derivatives modulate KEAP1-NRF2-xCT pathway to alleviate Sjögren's disease: insights from scRNA-seq and systems biology. Frontiers in immunology (2025)22. A Natural Extract Derived from Fish Scales Prevents Type 1 Diabetes in Nonobese Diabetic Mice by Modulating Gut Microbiota and Serum Metabolomics. ACS omega (2025)23. Spatial multi-omics profiling uncovers metabolic heterogeneity in Sjögren's syndrome and identifies PS(36:1) as a potential therapeutic target. Journal of translational medicine (2025)24. Sialylation-related gene signature predict prognosis and immunotherapy efficacy in low- and high-grade glioma: a PCA-based stratification study. Frontiers in oncology (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.