C57BL/6NGpt

Mouse Model: C57BL/6NGpt
Strain Number: D000274

Inbred strain

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6NGpt
Strain Number: D000274
Strain Strategy: D000274.C57BL_6NGpt strain info.pdf
Strain Background: [D000274] C57BL/6NGpt
Modification Type: Inbred strain
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. RNAi targeting heparin cofactor II promotes hemostasis in hemophilia A. Molecular Therapy-Nucleic Acids (2021)2. The Short-Day Cycle Induces Intestinal Epithelial Purine Metabolism Imbalance and Hepatic Disfunctions in Antibiotic-Mediated Gut Microbiota Perturbation Mice. Int J Mol Sci (2022)3. Effects of Fermented Green Tea Waste Extract Gels on Oxidative Damage in Short-Term Passive Smoking Mice. Gels (2022)4. Ban-xia-xie-xin-tang ameliorates hepatic steatosis by regulating Cidea and Cidec expression in HFD-fed mice. Phytomedicine (2022)5. Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression. Theranostics (2023)6. Rosiglitazone reduces diabetes angiopathy by inhibiting mitochondrial dysfunction dependent on regulating HSP22 expression. iScience (2023)7. Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis. Cell Death Dis (2023)8. PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway. Cell Mol Life Sci (2024)9. Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic target for HP1alpha-positive intrahepatic cholangiocarcinoma. J Exp Clin Cancer Res (2024)10. Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy. Frontiers in oncology (2025)11. Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility. Cells (2025)12. F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression. Nature communications (2025)13. Absolute Quantitative Detection of Hypervirulent Klebsiella pneumoniae Using a Novel Silicon-Doped Carbon Quantum Dot-Probe-Graphene Oxide. ACS sensors (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.