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huCD34+HSC-NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt(CH)

Mouse Model: huHSC-NCG(CH)
Strain Number: T037620

Knockout (KO)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: huCD34+HSC-NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt(CH)
Strain Number: T037620
Official Symbol: Prkdc,Il2rg
Strain Strategy: T037620.huHSC-NCG(CH) Strain info.pdf
Official Full Name: protein kinase, DNA activated, catalytic polypeptide,interleukin 2 receptor, gamma chain
Also Known As: DNA-PKcs,DNAPDcs,DNAPK,DNPK1,DOXNPH,HYRC1,XRCC7,dxnph,p460,scid,slip,CD132,[g]c,gamma(c),gc,p64
NCBI Number: 1909016186
MGI Number: 10477996551
Chromosome: 16#X
Research Areas: Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background: [N000235] NOD/ShiLtJGpt
Modification Type: Knockout (KO)
Inventory Status: Live
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy. Cell Rep (2023)2. Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma. Cell Reports Medicine (2024)3. Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2. Cell Commun Signal (2024)4. Deciphering MOSPD1's impact on breast cancer progression and therapeutic response. Biology Direct (2024)5. Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma. Science advances (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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