| Strain Name: |
huCD34+HSC-NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt(CH) |
| Strain Number: |
T037620 |
| Official Symbol: |
Prkdc,Il2rg |
| Strain Strategy: |
T037620.huHSC-NCG(CH) Strain info.pdf
|
| Official Full Name: |
protein kinase, DNA activated, catalytic polypeptide,interleukin 2 receptor, gamma chain |
| Also Known As: |
p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; AI326420; AU019811; DNA-PKcs,gc; p64; [g]c; CD132; gamma(c) |
| NCBI Number: |
1909016186
|
| Research Areas: |
Humanized model,Humanization of the immune system,Immunodeficiency |
| Strain Background: |
[N000235] NOD/ShiLtJGpt |
| Modification Type: |
Knockout (KO) |
| Inventory Status: |
Live |
| Sale Status: |
IF (Available for Distribution) |
| Health Status: |
Specific pathogen free (SPF) |
| Health Report: |
Please log in to view |
| Publications: |
1. Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy. Cell Rep (2023)2. Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma. Cell Reports Medicine (2024)3. Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2. Cell Commun Signal (2024)4. Deciphering MOSPD1's impact on breast cancer progression and therapeutic response. Biology Direct (2024)5. Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma. Science advances (2025)
|
