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huCD34+HSC-NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt(CH)

huHSC-NCG(CH)|Strain NO.T037620

Knockout (KO)

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BASIC INFORMATION
Strain Name: huCD34+HSC-NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt(CH)
Strain Number: T037620
Official Symbol: Prkdc,Il2rg
Strain Strategy: T037620.huHSC-NCG(CH) Strain info.pdf
Official Full Name: protein kinase, DNA activated, catalytic polypeptide,interleukin 2 receptor, gamma chain
Also Known As: DNA-PKcs,DNAPDcs,DNAPK,DNPK1,DOXNPH,HYRC1,XRCC7,dxnph,p460,scid,slip,CD132,[g]c,gamma(c),gc,p64
NCBI Number: 1909016186
MGI Number: 10477996551
Chromosome: 16#X
Research Areas: Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background: [N000235] NOD/ShiLtJGpt
Modification Type: Knockout (KO)
Inventory Status: Live
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy. Cell Rep (2023)2. Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma. Cell Reports Medicine (2024)3. Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2. Cell Commun Signal (2024)4. Deciphering MOSPD1's impact on breast cancer progression and therapeutic response. Biology Direct (2024)5. Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma. Science advances (2025)