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C57BL/6JGpt-Ace2em1Cin(hACE2-stop)/Gpt

hACE2（Extracellular humanization）|Strain NO.T037630

Knockin (KI)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Ace2em1Cin(hACE2-stop)/Gpt
Strain Number: T037630
Official Symbol: ACE2,Ace2,hACE2
Strain Strategy: T037630.hACE2(Extracellular humanization) Strategy-EN .pdfT037630.hACE2 Extracellular humanization strain info.pdf
Official Full Name: angiotensin I converting enzyme 2,angiotensin I converting enzyme
Also Known As: ACEH,2010305L05Rik
NCBI Number: 5927270008
Research Areas: Humanized model,Gene humanization model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Inventory Status: Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses. Immunity (2020)2. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nat Nanotechnol (2022)3. Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV-2 Variants. ACS Nano (2023)4. Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants. Nat Commun (2023)5. Administration of Lactobacillus plantarum GUANKE alleviates SARS-CoV-2-induced pneumonia in mice. Microbiol Spectr (2024)6. Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants. Nat Commun (2024)