C57BL/6JGpt-Myd88em1Cflox/Gpt
Mouse Model: Myd88-flox
Strain Number: T009598
Conditional knockout (cKO)
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- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Myd88em1Cflox/Gpt |
| Strain Number: | T009598 |
| Official Symbol: | Myd88 |
| Strain Strategy: | T009598.Myd88 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | myeloid differentiation primary response gene 88 |
| NCBI Number: | 17874 |
| MGI Number: | 108005 |
| Chromosome: | 9 |
| Distance Between Two Loxps: | 3600bp |
| Research Areas: | Metabolic research,Developmental Biology,immune system,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,hearing/ear,respiratory system,adipose tissue,Cell Proliferation,Cell death,DNA transcription,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,growth/size/body,hematopoietic system,Cell localization,cell nucleus,Organelles membrane,synapse |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T009598.Myd88 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Macrophage-specific MyD88 deletion and pharmacological inhibition prevents liver damage in non-alcoholic fatty liver disease via reducing inflammatory response. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2022)2. Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation. Adv Sci (Weinh) (2022)3. Myeloid MyD88 Mediates Macrophage Infiltration and Activation in Ang II‐Induced Cardiac Hypertrophy. Journal of cellular and molecular medicine (2025) |
| Gene Family: | My-T-BRC complexTIR domain containing |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.