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C57BL/6JGpt-Acss2em22Cd4454/Gpt

Mouse Model: Acss2-KO
Strain Number: T017245

Knockout (KO)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Acss2em22Cd4454/Gpt
Strain Number: T017245
Official Symbol: Acss2
Strain Strategy: T017245.Acss2 Cas9-KO Strategy-EN.pdfT017245. Acss2-KO strain info.pdf
Official Full Name: acyl-CoA synthetase short-chain family member 2
Also Known As: 1110017C11Rik,ACAS,ACS,Acas1,Acas2,AceCS1,Acs1,aceCS
NCBI Number: 60525
MGI Number: 1890410
Chromosome: 2
Deletion (size): -4454bp
Research Areas: Metabolic research,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Physiological system,digestive/alimentary system,liver/biliary system,Cell biology,cell nucleus,Molecular biology,ligase
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T017245.Acss2 Genotyping Protocol(KO).pdf
Inventory Status: Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Transl Psychiatry (2023)2. ACSS2 controls PPARgamma activity homeostasis to potentiate adipose-tissue plasticity. Cell Death Differ (2024)3. Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-kappaB pathway. Cell Commun Signal (2024)4. ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation. Nature communications (2025)
Gene Family: Acyl-CoA synthetase family

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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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