C57BL/6JGpt-Acss2em22Cd4454/Gpt
Acss2-KO|Strain NO.T017245
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Acss2em22Cd4454/Gpt |
| Strain Number: | T017245 |
| Official Symbol: | Acss2 |
| Strain Strategy: | T017245.Acss2 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | acyl-CoA synthetase short-chain family member 2 |
| Also Known As: | 1110017C11Rik,ACAS,ACS,Acas1,Acas2,AceCS1,Acs1,aceCS |
| NCBI Number: | 60525 |
| MGI Number: | 1890410 |
| Chromosome: | 2 |
| Deletion (size): | -4454bp |
| Research Areas: | Metabolic research,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Physiological system,digestive/alimentary system,liver/biliary system,Cell biology,cell nucleus,Molecular biology,ligase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T017245.Acss2 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels2. ACSS2 controls PPARgamma activity homeostasis to potentiate adipose-tissue plasticity3. Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-kappaB pathway |
| Gene Family: | Acyl-CoA synthetase family |