Hot Search:

C57BL/6JGpt-Acss2em22Cd4454/Gpt

Acss2-KO|Strain NO.T017245

Knockout (KO)

  • Product Type:
  • Quantity: - +
  • Sex:
  • Age:
  • Genotype:
BASIC INFORMATION
Strain Name: C57BL/6JGpt-Acss2em22Cd4454/Gpt
Strain Number: T017245
Official Symbol: Acss2
Strain Strategy: T017245.Acss2 Cas9-KO Strategy-EN.pdfT017245. Acss2-KO strain info.pdf
Official Full Name: acyl-CoA synthetase short-chain family member 2
Also Known As: 1110017C11Rik,ACAS,ACS,Acas1,Acas2,AceCS1,Acs1,aceCS
NCBI Number: 60525
MGI Number: 1890410
Chromosome: 2
Deletion (size): -4454bp
Research Areas: Metabolic research,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Physiological system,digestive/alimentary system,liver/biliary system,Cell biology,cell nucleus,Molecular biology,ligase
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T017245.Acss2 Genotyping Protocol(KO).pdf
Inventory Status: Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Transl Psychiatry (2023)2. ACSS2 controls PPARgamma activity homeostasis to potentiate adipose-tissue plasticity. Cell Death Differ (2024)3. Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-kappaB pathway. Cell Commun Signal (2024)4. ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation. Nature communications (2025)
Gene Family: Acyl-CoA synthetase family