C57BL/6JGpt-Grk2em3Cd1783/Gpt
Grk2-KO|Strain NO.T014508
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Grk2em3Cd1783/Gpt |
| Strain Number: | T014508 |
| Official Symbol: | Grk2 |
| Strain Strategy: | Log in to read more |
| Official Full Name: | G protein-coupled receptor kinase 2 |
| Also Known As: | Adrbk-1,Adrbk1,Bark-1,beta ARK,betaARK1 |
| NCBI Number: | 110355 |
| MGI Number: | 87940 |
| Chromosome: | 19 |
| Deletion (size): | -1783bp |
| Research Areas: | Metabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,immune system,nervous system,synapse,Physiological system,integument,cardiovascular system,Muscle ,hematopoietic system,Cell biology,Cell Proliferation,Cell death,Mitochondrial research,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis. Pharmaceuticals (2023)2. GRK2 mediates cisplatin-induced acute liver injury via the modulation of NOX4. Cell Biol Toxicol (2024)3. Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis. International journal of biological sciences (2025)4. GRK2 dysfunction mediates acute kidney injury in murine administered methotrexate combined with omeprazole. Acta pharmacologica Sinica (2025) |
| Gene Family: | AGC family kinasesPleckstrin homology domain containing |