C57BL/6JGpt-Anxa1em1Cflox/Gpt
Mouse Model: Anxa1-flox
Strain Number: T016067
Conditional knockout (cKO)
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- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Anxa1em1Cflox/Gpt |
| Strain Number: | T016067 |
| Official Symbol: | Anxa1 |
| Strain Strategy: | T016067.Anxa1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | annexin A1 |
| Also Known As: | Anx-1,Anx-A1,C430014K04Rik,Lpc-1,Lpc1 |
| NCBI Number: | 16952 |
| MGI Number: | 96819 |
| Chromosome: | 19 |
| Distance Between Two Loxps: | 9700bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,synapse,Physiological system,cardiovascular system,skeleton,craniofacial ,digestive/alimentary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell Proliferation,Cell death,Cytoskeleton,Mitochondrial research,cellular,Cell localization,Cytoplasmic vesicle,endosome,cell nucleus,cytomembrane,Organelles membrane,Molecular biology,Signal Transduction,DNA binding protein,Regulation of enzyme activity,hydrolytic enzyme,Lipid binding protein,RNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T016067.Anxa1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. VIP Stabilizes the Cytoskeleton of Schlemm’s Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation. Oxidative Medicine and Cellular Longevity (2021)2. Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway. Journal for ImmunoTherapy of Cancer (2024)3. Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils. Nat Commun (2025) |
| Gene Family: | AnnexinsReceptor ligands |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.