C57BL/6JGpt-Spp1em1Cflox/Gpt
Mouse Model: Spp1-flox
Strain Number: T012963
Conditional knockout (cKO)
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- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Spp1em1Cflox/Gpt |
| Strain Number: | T012963 |
| Official Symbol: | Spp1 |
| Strain Strategy: | T012963.Spp1 Cas9-CKO Strain Strategy.pdf |
| Official Full Name: | secreted phosphoprotein 1 |
| Also Known As: | 2AR,Apl-1,BNSP,BSPI,Bsp,ETA-1,Eta,OP,Opn,Opnl,Ric,Spp-1 |
| NCBI Number: | 20750 |
| MGI Number: | 98389 |
| Chromosome: | 5 |
| Distance Between Two Loxps: | 6563bp |
| Research Areas: | Metabolic research,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,cardiovascular system,skeleton,Muscle ,respiratory system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,Golgi apparatus,Molecular biology,Signal Transduction,DNA transcription |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T012963.Spp1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment. Nat Commun (2025)2. Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment. Signal transduction and targeted therapy (2025)3. Single-cell and spatial transcriptomics profile the interaction of SPP1+ macrophages and FAP+ fibroblasts in non-small cell lung cancer. Translational lung cancer research (2025) |
| Gene Family: | Receptor ligandsSIBLING family |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.