C57BL/6JGpt-Gsdmdem16Cd723/Gpt
Gsdmd-KO|Strain NO.T010437
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Gsdmdem16Cd723/Gpt |
| Strain Number: | T010437 |
| Official Symbol: | Gsdmd |
| Strain Strategy: | T010437.Gsdmd Cas9-KO Strategy-EN.pdfT010437.Gsdmd-KO strain info.pdf |
| Official Full Name: | gasdermin D |
| Also Known As: | 1810036L03Rik,AW558049,DF5L,Dfna5l,GsdmD-1,Gsdmdc1,M2-4 |
| NCBI Number: | 69146 |
| MGI Number: | 1916396 |
| Chromosome: | 15 |
| Deletion (size): | -723bp |
| Research Areas: | Developmental Biology,mortality/aging,immune system,Physiological system,digestive/alimentary system,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T010437.Gsdmd Genotyping Protocol(KO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis2. Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration3. Gasdermin D affects aortic vascular smooth muscle cell pyroptosis and Ang II-induced vascular remodeling4. NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation5. A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis6. Gasdermin D-mediated metabolic crosstalk promotes tissue repair |
| Gene Family: | Gasdermins |