C57BL/6JGpt[GF]

C57BL/6JGpt(Germ-Free)|Strain NO.N000295

Inbred strain

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt[GF]
Strain Number:	N000295
Official Symbol:
Strain Strategy:	N000295.C57BL_6JGPT[GF] strain info.pdf
Research Areas:	Humanized model,Humanized model of bacterial flora,Germ-free mice
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Inbred strain
Inventory Status:	Live
Sale Status:	IF (Available for Distribution)
Health Status:	Germfree (GF)
Health Report:	Please log in to view
Publications:	1. Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy. EMBO Molecular Medicine (2021)2. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology (2022)3. High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption. Nat Metab (2022)4. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nature Communications (2023)5. Targeting gut microbiota–derived kynurenine to predict and protect the remodeling of the pressureoverloaded young heart. SCIENCE ADVANCES (2023)6. Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis. iScience (2023)7. Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders. Brain (2023)8. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell (2024)9. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell (2024)10. Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon. Cell Metab (2024)11. EGCG protects intestines of mice and pelvic cancer patients against radiation injury via the gut microbiota/D-tagatose/AMPK axis. Radiother Oncol (2024)12. Microbiome-induced reprogramming in post-transcriptional landscape using nanopore direct RNA sequencing. Cell Rep (2024)13. Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice. Nat Commun (2024)14. Probiotics and their metabolite spermidine enhance IFN-γ+ CD4+ T cell immunity to inhibit hepatitis B virus. Cell Reports Medicine (2024)