C57BL/6JGpt[GF]

Mouse Model: C57BL/6JGpt(Germ-Free)
Strain Number: N000295

Inbred strain

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt[GF]
Strain Number: N000295
Official Symbol:
Strain Strategy: Log in to read more
Research Areas: Humanized model,Humanized model of bacterial flora,Germ-free mice
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Inbred strain
Inventory Status: Live
Sale Status: IF (Available for Distribution)
Health Status: Germfree (GF)
Health Report: Please log in to view
Publications: 1. Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy. EMBO Molecular Medicine (2021)2. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nature Immunology (2022)3. High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption. Nat Metab (2022)4. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nature Communications (2023)5. Targeting gut microbiota–derived kynurenine to predict and protect the remodeling of the pressureoverloaded young heart. SCIENCE ADVANCES (2023)6. Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis. iScience (2023)7. Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders. Brain (2023)8. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell (2024)9. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell (2024)10. Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon. Cell Metab (2024)11. EGCG protects intestines of mice and pelvic cancer patients against radiation injury via the gut microbiota/D-tagatose/AMPK axis. Radiother Oncol (2024)12. Microbiome-induced reprogramming in post-transcriptional landscape using nanopore direct RNA sequencing. Cell Rep (2024)13. Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice. Nat Commun (2024)14. Probiotics and their metabolite spermidine enhance IFN-γ+ CD4+ T cell immunity to inhibit hepatitis B virus. Cell Reports Medicine (2024)15. A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders. Cell Discov (2025)16. Dietary emulsifier carboxymethylcellulose-induced gut dysbiosis and SCFA reduction aggravate acute pancreatitis through classical monocyte activation. Microbiome (2025)17. Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness. Signal Transduct Target Ther (2025)18. Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets. Frontiers in veterinary science (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.