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C57BL/6JGpt-Padi4em6Cd1080/Gpt

Padi4-KO|Strain NO.T011513

Knockout (KO)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Padi4em6Cd1080/Gpt
Strain Number: T011513
Official Symbol: Padi4
Strain Strategy: T011513.Padi4 Cas9-KO Strategy-EN.pdf
Official Full Name: peptidyl arginine deiminase, type IV
Also Known As: Pad4,Pdi4
NCBI Number: 18602
MGI Number: 1338898
Chromosome: 4
Deletion (size): -1080bp
Research Areas: Physiological system,renal/urinary system
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T011513.Padi4 Genotyping Protocol(KO).pdf
Inventory Status: Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis. MedComm (2022)2. The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis. Front Immunol (2023)3. Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis. Front Endocrinol (2023)4. The scaffold of neutrophil extracellular traps promotes CCA progression and modulates angiogenesis via ITGAV/NFkappaB. Cell Commun Signal (2024)5. Increased neutrophil extracellular traps caused by diet‐induced obesity delay fracture healing. FASEB J (2024)6. Neutrophil extracellular traps induce barrier dysfunction in DSS-induced ulcerative colitis via the cGAS-STING pathway. Int Immunopharmacol (2024)
Gene Family: Peptidyl arginine deiminases