C57BL/6JGpt-Gpbar1em1Cflox/Gpt
Gpbar1-flox|Strain NO.T008782
Conditional knockout (cKO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Gpbar1em1Cflox/Gpt |
| Strain Number: | T008782 |
| Official Symbol: | Gpbar1 |
| Strain Strategy: | T008782.Gpbar1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | G protein-coupled bile acid receptor 1 |
| Also Known As: | BG37,GPCR,GPR131,M-BAR,TGR5 |
| NCBI Number: | 227289 |
| MGI Number: | 2653863 |
| Chromosome: | 1 |
| Distance Between Two Loxps: | 6436bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,growth/size/body,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,Cell biology,Cell Proliferation,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T008782.Gpbar1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Roles and Mechanisms of TGR5 in the Modulation of CD4+ T Cell Functions in Myocardial Infarction2. Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis3. Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy |
| Gene Family: | G protein-coupled bile acid receptor |