C57BL/6JGpt-Gpbar1em1Cflox/Gpt
Mouse Model: Gpbar1-flox
Strain Number: T008782
Conditional knockout (cKO)
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- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Gpbar1em1Cflox/Gpt |
| Strain Number: | T008782 |
| Official Symbol: | Gpbar1 |
| Strain Strategy: | Log in to read more |
| Official Full Name: | G protein-coupled bile acid receptor 1 |
| Also Known As: | BG37,GPCR,GPR131,M-BAR,TGR5 |
| NCBI Number: | 227289 |
| MGI Number: | 2653863 |
| Chromosome: | 1 |
| Distance Between Two Loxps: | 6436bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,growth/size/body,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,Cell biology,Cell Proliferation,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Roles and Mechanisms of TGR5 in the Modulation of CD4+ T Cell Functions in Myocardial Infarction. Journal of Cardiovascular Translational Research (2021)2. Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis. Cell Metabolism (2021)3. Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy. Nat Metab (2024)4. Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. J Transl Med (2024)5. Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis. Adv Sci (Weinh) (2025) |
| Gene Family: | G protein-coupled bile acid receptor |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.