C57BL/6JGpt-Gpbar1em1Cflox/Gpt
Gpbar1-flox|Strain NO.T008782
Conditional knockout (cKO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Gpbar1em1Cflox/Gpt |
| Strain Number: | T008782 |
| Official Symbol: | Gpbar1 |
| Strain Strategy: | T008782.Gpbar1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | G protein-coupled bile acid receptor 1 |
| Also Known As: | BG37,GPCR,GPR131,M-BAR,TGR5 |
| NCBI Number: | 227289 |
| MGI Number: | 2653863 |
| Chromosome: | 1 |
| Distance Between Two Loxps: | 6436bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,growth/size/body,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,Cell biology,Cell Proliferation,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T008782.Gpbar1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Roles and Mechanisms of TGR5 in the Modulation of CD4+ T Cell Functions in Myocardial Infarction2. Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis3. Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy4. Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation |
| Gene Family: | G protein-coupled bile acid receptor |