C57BL/6JGpt-Grin2bem1Cflox/Gpt
Mouse Model: Grin2b-flox
Strain Number: T009537
Conditional knockout (cKO)
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- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Grin2bem1Cflox/Gpt |
| Strain Number: | T009537 |
| Official Symbol: | Grin2b |
| Strain Strategy: | T009537.Grin2b Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
| Also Known As: | AW490526,GluN2B,GluRepsilon2,NR2B,Nmdar2b |
| NCBI Number: | 14812 |
| MGI Number: | 95821 |
| Chromosome: | 6 |
| Distance Between Two Loxps: | 2300bp |
| Research Areas: | Metabolic research,Developmental Biology,nervous system,Signal Transduction,Cell death,Protein metabolism,homeostasis/metabolism,behavior/neurological,Cell biology,Molecular biology,cellular,growth/size/body,mortality/aging,Cell localization,Cytoplasmic vesicle,endosome,Organelles membrane,synapse,transporter |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T009537.Grin2b Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain. Brain Behav Immun (2022)2. Activation of the N-methyl-D-aspartate receptor contributes to orofacial neuropathic and inflammatory allodynia by facilitating calcium-calmodulin-dependent protein kinase II phosphorylation in mice. Brain research bulletin (2022) |
| Gene Family: | Glutamate ionotropic receptor NMDA type subunits |
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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.