C57BL/6JGpt-Ythdf1em1Cflox/Gpt
Ythdf1-flox|Strain NO.T009315
Conditional knockout (cKO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
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BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Ythdf1em1Cflox/Gpt |
| Strain Number: | T009315 |
| Official Symbol: | Ythdf1 |
| Strain Strategy: | T009315. Ythdf1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | YTH N6-methyladenosine RNA binding protein 1 |
| Also Known As: | 2210410K23Rik,8030473O16 |
| NCBI Number: | 228994 |
| MGI Number: | 1917431 |
| Chromosome: | 2 |
| Distance Between Two Loxps: | 1114bp |
| Research Areas: | Metabolic research,Protein metabolism,Developmental Biology,cell differentiation,Physiological system,cardiovascular system,Cell biology,cellular,Molecular biology,Signal Transduction,RNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T009315.Ythdf1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. J Neuroinflammation (2022)2. YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules. Redox Biol (2023)3. YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice. BMC Medicine (2024)4. YTHDF1 activates FBW7 transcription by regulating m6A-dependent FOXO1 to facilitate inflammatory response in ulcerative colitis-like model. Autoimmunity (2025) |