C57BL/6JGpt-Ythdf1em1Cflox/Gpt
Mouse Model: Ythdf1-flox
Strain Number: T009315
Conditional knockout (cKO)
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Ythdf1em1Cflox/Gpt |
| Strain Number: | T009315 |
| Official Symbol: | Ythdf1 |
| Strain Strategy: | T009315. Ythdf1 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | YTH N6-methyladenosine RNA binding protein 1 |
| Also Known As: | 2210410K23Rik,8030473O16 |
| NCBI Number: | 228994 |
| MGI Number: | 1917431 |
| Chromosome: | 2 |
| Distance Between Two Loxps: | 1114bp |
| Research Areas: | Metabolic research,Protein metabolism,Developmental Biology,cell differentiation,Physiological system,cardiovascular system,Cell biology,cellular,Molecular biology,Signal Transduction,RNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T009315.Ythdf1 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray. J Neuroinflammation (2022)2. YTHDF1 mitigates acute kidney injury via safeguarding m(6)A-methylated mRNAs in stress granules of renal tubules. Redox Biol (2023)3. YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice. BMC Medicine (2024)4. YTHDF1 activates FBW7 transcription by regulating m6A-dependent FOXO1 to facilitate inflammatory response in ulcerative colitis-like model. Autoimmunity (2025) |
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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.