C57BL/6JGpt-Fgf4em1Cflox/Gpt
Mouse Model: Fgf4-flox
Strain Number: T009264
Conditional knockout (cKO)
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Fgf4em1Cflox/Gpt |
| Strain Number: | T009264 |
| Official Symbol: | Fgf4 |
| Strain Strategy: | T009264.Fgf4 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | fibroblast growth factor 4 |
| Also Known As: | Fgf-4,Fgfk,HBGF-4,Hst1,Hstf-1,KS3,hst,hst-1,kFGF |
| NCBI Number: | 14175 |
| MGI Number: | 95518 |
| Chromosome: | 7 |
| Distance Between Two Loxps: | 15000bp |
| Research Areas: | Metabolic research,Protein metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,nervous system,vision/eye,Physiological system,skeleton,reproductive system,limbs/digits/tail,Cell biology,Cell Proliferation,Cell death,cellular,Molecular biology,Signal Transduction,DNA transcription |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T009264.Fgf4 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis. Hepatology (2022)2. A non-mitogenic FGF4 analog alleviates non-alcoholic steatohepatitis through an AMPK-dependent pathway. Biochim Biophys Acta Mol Basis Dis (2022) |
| Gene Family: | Fibroblast growth factor familyReceptor ligands |
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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.