C57BL/6JGpt-Nlrp3em7Cd4411/Gpt
Mouse Model: Nlrp3-KO
Strain Number: T010873
Knockout (KO)
- Product Type:
- Quantity: - +
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- Age:
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Nlrp3em7Cd4411/Gpt |
| Strain Number: | T010873 |
| Official Symbol: | Nlrp3 |
| Strain Strategy: | T010873. Nlrp3 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | NLR family,pyrin domain containing 3 |
| Also Known As: | AGTAVPRL,AII/AVP,Cias1,FCAS,FCU,MWS,Mmig1,NALP3,Pypaf1 |
| NCBI Number: | 216799 |
| MGI Number: | 2653833 |
| Chromosome: | 11 |
| Deletion (size): | -4411bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Inflammation,nervous system,Physiological system,integument,skeleton,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,limbs/digits/tail,Cell biology,Cell death,cellular,Cell localization,endoplasmic reticulum,Golgi apparatus,cell nucleus,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T010873.Nlrp3 Genotyping Protocol(KO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Berberine augments hypertrophy of colonic patches in mice with intraperitoneal bacterial infection. International Immunopharmacology (2021)2. Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways. Acta Pharmacologica Sinica (2021)3. Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol. ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2022)4. Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy. Int J Biol Sci (2024)5. The LTB4-BLT1 axis attenuates influenza-induced lung inflammation by suppressing NLRP3 activation. Cell Death Discov (2025)6. NLRP3 regulates macrophage function by M-CSF/M-CSFR signaling in acute radiation-induced lung injury. Molecular immunology (2025) |
| Gene Family: | NLR familyPyrin domain containing |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.