Nlrp3-KO|Strain NO.T010873

Knockout (KO)

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Strain Name: C57BL/6JGpt-Nlrp3em7Cd4411/Gpt
Strain Number: T010873
Official Symbol: Nlrp3
Strain Strategy: T010873. Nlrp3 Cas9-KO Strategy-EN.pdf
Official Full Name: NLR family, pyrin domain containing 3
Also Known As: AGTAVPRL,AII/AVP,Cias1,FCAS,FCU,MWS,Mmig1,NALP3,Pypaf1
NCBI Number: 216799
MGI Number: 2653833
Chromosome: 11
Deletion (size): -4411bp
Research Areas: Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Inflammation,nervous system,Physiological system,integument,skeleton,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,limbs/digits/tail,Cell biology,Cell death,cellular,Cell localization,endoplasmic reticulum,Golgi apparatus,cell nucleus,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T010873.Nlrp3 Genotyping Protocol(KO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Berberine augments hypertrophy of colonic patches in mice with intraperitoneal bacterial infection2. Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways3. Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol4. Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy
Gene Family: NLR familyPyrin domain containing