C57BL/6JGpt-Nlrp3em1Cflox/Gpt
Mouse Model: Nlrp3-flox
Strain Number: T010872
Conditional knockout (cKO)
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- Quantity: - +
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- Age:
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Nlrp3em1Cflox/Gpt |
| Strain Number: | T010872 |
| Official Symbol: | Nlrp3 |
| Strain Strategy: | T010872. Nlrp3 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | NLR family, pyrin domain containing 3 |
| Also Known As: | AGTAVPRL,AII/AVP,Cias1,FCAS,FCU,MWS,Mmig1,NALP3,Pypaf1 |
| NCBI Number: | 216799 |
| MGI Number: | 2653833 |
| Chromosome: | 11 |
| Distance Between Two Loxps: | 4500bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Inflammation,nervous system,Physiological system,integument,skeleton,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,limbs/digits/tail,Cell biology,Cell death,cellular,Cell localization,endoplasmic reticulum,Golgi apparatus,cell nucleus,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T010872.Nlrp3 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice. Cell Rep (2022)2. Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury. CNS Neuroscience & Therapeutics (2024)3. NLRP3 inflammasome constrains liver regeneration through impairing MerTK-mediated macrophage efferocytosis. Science advances (2025)4. ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury. Clin Transl Med (2025) |
| Gene Family: | NLR familyPyrin domain containing |
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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.