C57BL/6JGpt-Nlrp3em1Cflox/Gpt
Nlrp3-flox|Strain NO.T010872
Conditional knockout (cKO)
![](https://oss.gempharmatech.com/upload/20221109/detail-page2_06.jpg)
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BASIC INFORMATION
Strain Name: | C57BL/6JGpt-Nlrp3em1Cflox/Gpt |
Strain Number: | T010872 |
Official Symbol: | Nlrp3 |
Strain Strategy: | T010872. Nlrp3 Cas9-CKO Strategy-EN.pdf |
Official Full Name: | NLR family, pyrin domain containing 3 |
Also Known As: | AGTAVPRL,AII/AVP,Cias1,FCAS,FCU,MWS,Mmig1,NALP3,Pypaf1 |
NCBI Number: | 216799 |
MGI Number: | 2653833 |
Chromosome: | 11 |
Distance Between Two Loxps: | 4500bp |
Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Inflammation,nervous system,Physiological system,integument,skeleton,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,limbs/digits/tail,Cell biology,Cell death,cellular,Cell localization,endoplasmic reticulum,Golgi apparatus,cell nucleus,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
Strain Background: | [N000013] C57BL/6JGpt |
Modification Type: | Conditional knockout (cKO) |
Genotyping Protocols: | T010872.Nlrp3 Genotyping Protocol(CKO).pdf |
Inventory Status: | Cryopreserved |
Sale Status: | IF (Available for Distribution) |
Health Status: | Specific pathogen free (SPF) |
Publications: | 1. Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice2. Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury |
Gene Family: | NLR familyPyrin domain containing |