C57BL/6JGpt-Prkaa1em1Cflox/Gpt
Mouse Model: Prkaa1-flox
Strain Number: T007182
Conditional knockout (cKO)
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Prkaa1em1Cflox/Gpt |
| Strain Number: | T007182 |
| Official Symbol: | Prkaa1 |
| Strain Strategy: | Log in to read more |
| Official Full Name: | protein kinase, AMP-activated, alpha 1 catalytic subunit |
| Also Known As: | AI194361,AI450832,AL024255,AMPKalpha1,C130083N04Rik |
| NCBI Number: | 105787 |
| MGI Number: | 2145955 |
| Chromosome: | 15 |
| Distance Between Two Loxps: | 5600bp |
| Research Areas: | Metabolic research,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,immune system,Physiological system,Muscle ,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia/macrophage via the AMPK-PGC1α-PPARγ pathway to promote recovery in mice with spinal cord injury. Journal of neuroinflammation (2025)2. The anti-atherosclerosis effect and molecular mechanism of AMPKα1 by polarizing monocytes to an M2 phenotype via cell-intrinsic lysosomal lipolysis. Cardiovasc Pathol (2025) |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.