C57BL/6JGpt-Mettl3em1Cflox/Gpt
Mettl3-flox|Strain NO.T006659
Conditional knockout (cKO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
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BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Mettl3em1Cflox/Gpt |
| Strain Number: | T006659 |
| Official Symbol: | Mettl3 |
| Strain Strategy: | T006659. Mettl3 Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | methyltransferase like 3 |
| Also Known As: | 2310024F18Rik,M6A,Spo8 |
| NCBI Number: | 56335 |
| MGI Number: | 1927165 |
| Chromosome: | 14 |
| Distance Between Two Loxps: | 2436bp |
| Research Areas: | Metabolic research,Protein metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,Cell biology,cell nucleus,Molecular biology,Signal Transduction,RNA binding protein,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T006659.Mettl3 Genotyping Protocol(CKO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy2. Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms3. METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication4. METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial-Mesenchymal Transition in Gastric Precancerous Lesions |
| Gene Family: | m6A methyltransferase complexMethyltransferase like |