Hot Search:

C57BL/6JGpt-Mettl3em1Cflox/Gpt

Mettl3-flox|Strain NO.T006659

Conditional knockout (cKO)

  • Product Type:
  • Quantity: - +
  • Sex:
  • Age:
  • Genotype:
BASIC INFORMATION
Strain Name: C57BL/6JGpt-Mettl3em1Cflox/Gpt
Strain Number: T006659
Official Symbol: Mettl3
Strain Strategy: T006659. Mettl3 Cas9-CKO Strategy-EN.pdf
Official Full Name: methyltransferase like 3
Also Known As: 2310024F18Rik,M6A,Spo8
NCBI Number: 56335
MGI Number: 1927165
Chromosome: 14
Distance Between Two Loxps: 2436bp
Research Areas: Metabolic research,Protein metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,Cell biology,cell nucleus,Molecular biology,Signal Transduction,RNA binding protein,transferase
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Conditional knockout (cKO)
Genotyping Protocols: T006659.Mettl3 Genotyping Protocol(CKO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy. Cell Death Dis (2023)2. Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms. Science translational medicine (2022)3. METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication. Theranostics (2022)4. METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial-Mesenchymal Transition in Gastric Precancerous Lesions. Toxics (2024)5. METTL3 governs thymocyte development and thymic involution by regulating ferroptosis. Nat Commun (2024)6. Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells. Cell Mol Biol Lett (2024)7. METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)
Gene Family: m6A methyltransferase complexMethyltransferase like