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C57BL/6JGpt-Mettl3em1Cflox/Gpt

Mettl3-flox|Strain NO.T006659

Conditional knockout (cKO)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Mettl3em1Cflox/Gpt
Strain Number: T006659
Official Symbol: Mettl3
Strain Strategy: T006659. Mettl3 Cas9-CKO Strategy-EN.pdf
Official Full Name: methyltransferase like 3
Also Known As: 2310024F18Rik,M6A,Spo8
NCBI Number: 56335
MGI Number: 1927165
Chromosome: 14
Distance Between Two Loxps: 2436bp
Research Areas: Metabolic research,Protein metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,Cell biology,cell nucleus,Molecular biology,Signal Transduction,RNA binding protein,transferase
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Conditional knockout (cKO)
Genotyping Protocols: T006659.Mettl3 Genotyping Protocol(CKO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy2. Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms3. METTL3-mediated N6-methyladenosine modification governs pericyte dysfunction during diabetes-induced retinal vascular complication4. METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial-Mesenchymal Transition in Gastric Precancerous Lesions5. METTL3 governs thymocyte development and thymic involution by regulating ferroptosis6. Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells
Gene Family: m6A methyltransferase complexMethyltransferase like