C57BL/6JGpt-C3ar1em6Cd4816/Gpt
Mouse Model: C3ar1-KO
Strain Number: T006106
Knockout (KO)
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- Quantity: - +
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-C3ar1em6Cd4816/Gpt |
| Strain Number: | T006106 |
| Official Symbol: | C3ar1 |
| Strain Strategy: | T006106.C3ar1 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | complement component 3a receptor 1 |
| Also Known As: | AZ3B,C3AR,HNFAG09 |
| NCBI Number: | 12267 |
| MGI Number: | 1097680 |
| Chromosome: | 6 |
| Deletion (size): | -4816bp |
| Research Areas: | Metabolic research,adipose tissue,homeostasis/metabolism,Developmental Biology,growth/size/body,mortality/aging,immune system,nervous system,vision/eye,Physiological system,skeleton,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell Proliferation,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T006106.C3ar1 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome. Life Sci (2022)2. C3a/C3aR synergies with TGF-beta to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome. J Transl Med (2023)3. Astrocyte-derived complement C3 facilitated microglial phagocytosis of synapses in Staphylococcus aureus-associated neurocognitive deficits. PLoS Pathog (2025) |
| Gene Family: | Complement component GPCRsComplement system regulators and receptors |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.