C57BL/6JGpt-Nlrp12em21Cd7903/Gpt
Mouse Model: Nlrp12-KO
Strain Number: T006031
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Nlrp12em21Cd7903/Gpt |
| Strain Number: | T006031 |
| Official Symbol: | Nlrp12 |
| Strain Strategy: | T006031.Nlrp12 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | NLR family, pyrin domain containing 12 |
| Also Known As: | Nalp12,PYPAF7,monarch-1 |
| NCBI Number: | 378425 |
| MGI Number: | 2676630 |
| Chromosome: | 7 |
| Deletion (size): | -7903bp |
| Research Areas: | Metabolic research,immune system,Tumor research,Signal Transduction,Cell death,DNA transcription,digestive/alimentary system,Protein metabolism,Physiological system,homeostasis/metabolism,Cell biology,Molecular biology,cellular,hematopoietic system,Cell localization |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T006031.Nlrp12 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma. Cancer Immunol Immunother (2024)2. AIP1 Regulates Ocular Angiogenesis Via NLRP12‐ASC‐Caspase‐8 Inflammasome‐Mediated Endothelial Pyroptosis. Adv Sci (Weinh) (2024) |
| Gene Family: | NLR familyPyrin domain containing |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.