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C57BL/6JGpt-H11em1Cin(hS100A8-iCre)/Gpt

Model: S100A8-iCre
Strain Number: T005636

Knockin (KI)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-H11em1Cin(hS100A8-iCre)/Gpt
Strain Number: T005636
Official Symbol: S100A8,iCre
Strain Strategy: T005636.H11-hS100A8-iCre-polyA Strategy-EN.pdfT005636.S100A8-iCre strain info.pdf
Official Full Name: S100 calcium binding protein A8
Also Known As: P8,MIF,NIF,CAGA,CFAG,CGLA,L1Ag,MRP8,CP-10,MA387,60B8AG
NCBI Number: 6279
Chromosome: 11
Research Areas: Tool Mice,Cre/Dre
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Genotyping Protocols: T005636.S100A8-iCre Genotyping Protocol(KI) .pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis. MedComm (2022)2. PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow. Nat Commun (2022)3. Rhaponticin Alleviates Collagen-induced Arthritis by Inhibiting NLRP3/GSDMD-mediated Neutrophil Extracellular Traps. Inflammation (2024)4. CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases. Cancer cell (2025)5. GSDMD-Deficient G-MDSCs Exert Profoundly Suppressive Activity to Relieve MPTP-Induced Parkinson's Disease. CNS neuroscience & therapeutics (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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