C57BL/6JGpt-Tg(APP,hPSEN1)48/Gpt

Mouse Model: FAD2T(APP/PS1)
Strain Number: T005625

Transgenic (Tg)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Tg(APP,hPSEN1)48/Gpt
Strain Number: T005625
Official Symbol: App,Psen1
Strain Strategy: T005625.FAD2T(APP PS1) strain info.pdf
Official Full Name: amyloid beta (A4) precursor protein,presenilin 1
Also Known As: Ag,Abpp,Adap,Cvap,Abeta,betaApp,E030013M08Rik,PS1,Ad3h,PS-1,S182
NCBI Number: 1182019164
Research Areas: Disease Models,Neurodegenerative diseases,Alzheimer's disease
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Transgenic (Tg)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Icariin improves learning and memory function by enhancing HRD1-mediated ubiquitination of amyloid precursor protein in APP/PS1 mice. Journal of Alzheimer's disease : JAD (2025)2. Radiofluorination of 2-Arylquinolin-4-yl Oxypropanamide Derivatives for TSPO Imaging in Neuroinflammatory Murine, Nonhuman Primates, and Human Brain Autoradiography with Insensitivity to the rs6971 Polymorphism. Journal of medicinal chemistry (2025)3. Late-Stage Activation of Toll-like receptor 3 Alleviates Cognitive Impairment and Neuropathology in an Alzheimer's Disease Mouse Model. Molecular neurobiology (2025)4. Calycosin improved long-term memory impairment in the very early of APP/PS1 mice. Brain research (2025)5. Synthetic efferocytic receptor microglia enhances anti-inflammatory clearance of amyloid-β for AD treatment in mice. Science advances (2025)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.