FVB/NJGpt-Tg(MMTV-PyMT)/Gpt

Mouse Model: FVB-MMTV-PyMT
Strain Number: T004993

Transgenic (Tg)

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: FVB/NJGpt-Tg(MMTV-PyMT)/Gpt
Strain Number: T004993
Official Symbol: Fam89b
Strain Strategy: T004993.FVB-MMTV-PyMT strain info.pdf
Official Full Name: family with sequence similarity 89, member B
Also Known As: 1110021A21Rik,MMTV,Mtvr2
NCBI Number: 17826
MGI Number: 106595
Research Areas: Disease Models,Tumor model,Spontaneous tumor
Strain Background: [N000026] FVB/NJGpt
Modification Type: Transgenic (Tg)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Interleukin-16 enhances anti-tumor immune responses by establishing a Th1 cell-macrophage crosstalk through reprogramming glutamine metabolism in mice. Nat Commun (2025)2. GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer. BMC Biol (2024)3. Cucurbitacin B stimulates PD-1 immunotherapy response in malignant breast cancer by covalent targeting MTCH2. Phytomedicine (2025)4. NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis. J Exp Clin Cancer Res (2025)5. Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)6. A circular RNA activated by TGFbeta promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability. Nat Commun (2023)7. A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy. Nature nanotechnology (2025)8. Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII(hi) neutrophils. Signal Transduct Target Ther (2023)9. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature (2022)

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.