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C57BL/6JGpt-Rag1em1Cd3259/Gpt

Mouse Model: B6-Rag1-KO
Strain Number: T004753

Knockout (KO)

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Rag1em1Cd3259/Gpt
Strain Number: T004753
Official Symbol: Rag1
Strain Strategy: T004753. B6-Rag1-KO strain info.pdf
Official Full Name: recombination activating 1
Also Known As: Rag-1
NCBI Number: 19373
MGI Number: 97848
Chromosome: 2
Deletion (size): -3259bp
Research Areas: Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. Journal of Hematology & Oncology (2021)2. Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation. Pharmacological Research (2021)3. Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ. Frontiers in cell and developmental biology (2021)4. Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity. Journal for immunotherapy of cancer (2021)5. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-beta signaling in regulatory T cells. Cell Rep (2022)6. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Nat Commun (2022)7. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression. Nat Commun (2022)8. Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation. Oncoimmunology (2022)9. Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity. Nat Commun (2022)10. Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis. Nature Communications (2023)11. Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection. Microbiol Spectr (2023)12. Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8(+) T-cell exhaustion. Nat Commun (2023)13. RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. Cell Rep (2024)14. Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice. Cell Rep (2024)15. A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice. J Cell Mol Med (2024)16. The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells. Cell Rep (2024)17. Reconstituted CD74(+) NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation. J Autoimmun (2024)18. VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation. J Inflamm Res (2024)19. Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling. Nature Communications (2024)20. PAC1 constrains type II inflammation through promotion of CGRP signaling in ILC2s. The journal of Clinical Investigation (2024)21. Crystalline silica-induced recruitment and immuno-imbalance of CD4(+) tissue resident memory T cells promote silicosis progression. Commun Biol (2024)22. Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease. Gut microbes (2025)23. KLHL25-ACLY module functions as a switch in the fate determination of the differentiation of iTreg/Th17. Commun Biol (2025)24. Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn's disease. J Transl Med (2025)25. The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity. Journal of Neuroinflammation (2022)26. Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes. Nat Commun (2025)27. Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy. EMBO Molecular Medicine (2021)28. A pathological joint-liver axis mediated by matrikine-activated CD4(+) T cells. Signal Transduct Target Ther (2024)29. TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis. Nature communications (2025)30. TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma. Nature Communications (2024)31. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease. Cell Host Microbe (2024)32. A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis. Cell Res (2023)33. AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression. Sci Adv (2025)34. ACAT1 regulates tertiary lymphoid structures and correlates with immunotherapy response in non-small cell lung cancer. J Clin Invest (2025)35. Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells. J Clin Invest (2023)36. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8(+) T cell responses. Cell Metab (2023)37. Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy. Nat Commun (2025)38. TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion. Nature communications (2025)39. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell (2024)
Gene Family: DNA transposon derived genesRing finger proteins

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