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C57BL/6JGpt-
Rag1
em1Cd3259
/Gpt
B6-Rag1-KO|Strain NO.T004753
Knockout (KO)
Product Type:
Live Mouse
Frozen Embryo
Quantity:
-
+
Sex:
Male
Female
Age:
1 weeks
2 weeks
3 weeks
4 weeks
5 weeks
6 weeks
7 weeks
8 weeks
9 weeks
10 weeks
11 weeks
12 weeks
13 weeks
14 weeks
15 weeks
16 weeks
17 weeks
18 weeks
19 weeks
20 weeks
21 weeks
22 weeks
23 weeks
24 weeks
25 weeks
26 weeks
27 weeks
28 weeks
29 weeks
30 weeks
>30 weeks
Genotype:
(Rag1)KO/KO
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BASIC INFORMATION
Strain Name:
C57BL/6JGpt-
Rag1
em1Cd3259
/Gpt
Strain Number:
T004753
Official Symbol:
Rag1
Strain Strategy:
T004753.B6-Rag1-KO strain info.pdf
Official Full Name:
recombination activating 1
Also Known As:
Rag-1
NCBI Number:
19373
MGI Number:
97848
Chromosome:
2
Deletion (size):
-3259bp
Research Areas:
Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background:
[N000013] C57BL/6JGpt
Modification Type:
Knockout (KO)
Inventory Status:
Live,Cryopreserved
Sale Status:
IF (Available for Distribution)
Health Status:
Specific pathogen free (SPF)
Health Report:
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Publications:
1. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors
2. Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation
3. Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
4. Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy
5. Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity
6. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-beta signaling in regulatory T cells
7. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness
8. The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity
9. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression
10. Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation
11. Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity
12. Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis
13. A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis
14. Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells
15. Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection
16. Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8(+) T-cell exhaustion
17. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8(+) T cell responses
18. RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis
19. Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice
20. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
21. A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice
22. A pathological joint-liver axis mediated by matrikine-activated CD4(+) T cells
23. The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells
24. Reconstituted CD74(+) NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation
25. VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation
26. TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma
27. Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling
28. PAC1 constrains type II inflammation through promotion of CGRP signaling in ILC2s
29. Crystalline silica-induced recruitment and immuno-imbalance of CD4(+) tissue resident memory T cells promote silicosis progression
Gene Family:
DNA transposon derived genes
Ring finger proteins
0
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