C57BL/6JGpt-Rag1^em1Cd3259/Gpt

B6-Rag1-KO|Strain NO.T004753

Knockout (KO)

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt-Rag1^em1Cd3259/Gpt
Strain Number:	T004753
Official Symbol:	Rag1
Strain Strategy:	Log in to read more
Official Full Name:	recombination activating 1
Also Known As:	Rag-1
NCBI Number:	19373
MGI Number:	97848
Chromosome:	2
Deletion (size):	-3259bp
Research Areas:	Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Knockout (KO)
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. Journal of Hematology & Oncology (2021)2. Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation. Pharmacological Research (2021)3. Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ. Frontiers in cell and developmental biology (2021)4. Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy. EMBO Molecular Medicine (2021)5. Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity. Journal for immunotherapy of cancer (2021)6. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-beta signaling in regulatory T cells. Cell Rep (2022)7. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Nat Commun (2022)8. The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity. Journal of Neuroinflammation (2022)9. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression. Nat Commun (2022)10. Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation. Oncoimmunology (2022)11. Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity. Nat Commun (2022)12. Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis. Nature Communications (2023)13. A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis. Cell Res (2023)14. Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells. J Clin Invest (2023)15. Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection. Microbiol Spectr (2023)16. Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8(+) T-cell exhaustion. Nat Commun (2023)17. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8(+) T cell responses. Cell Metab (2023)18. RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis. Cell Rep (2024)19. Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice. Cell Rep (2024)20. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell (2024)21. A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice. J Cell Mol Med (2024)22. A pathological joint-liver axis mediated by matrikine-activated CD4(+) T cells. Signal Transduct Target Ther (2024)23. The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells. Cell Rep (2024)24. Reconstituted CD74(+) NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation. J Autoimmun (2024)25. VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation. J Inflamm Res (2024)26. TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma. Nature Communications (2024)27. Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling. Nature Communications (2024)28. PAC1 constrains type II inflammation through promotion of CGRP signaling in ILC2s. The journal of Clinical Investigation (2024)29. Crystalline silica-induced recruitment and immuno-imbalance of CD4(+) tissue resident memory T cells promote silicosis progression. Commun Biol (2024)30. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease. Cell Host Microbe (2024)31. Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease. Gut microbes (2025)32. KLHL25-ACLY module functions as a switch in the fate determination of the differentiation of iTreg/Th17. Commun Biol (2025)33. Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy. Nat Commun (2025)34. ACAT1 regulates tertiary lymphoid structures and correlates with immunotherapy response in non-small cell lung cancer. J Clin Invest (2025)35. AMPK-dependent Parkin activation suppresses macrophage antigen presentation to promote tumor progression. Sci Adv (2025)36. Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn's disease. J Transl Med (2025)37. Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes. Nat Commun (2025)38. TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion. Nature communications (2025)39. TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis. Nature communications (2025)
Gene Family:	DNA transposon derived genes Ring finger proteins