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C57BL/6JGpt-Rag1em1Cd3259/Gpt

B6-Rag1-KO|Strain NO.T004753

Knockout (KO)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Rag1em1Cd3259/Gpt
Strain Number: T004753
Official Symbol: Rag1
Strain Strategy: T004753.B6-Rag1-KO strain info.pdf
Official Full Name: recombination activating 1
Also Known As: Rag-1
NCBI Number: 19373
MGI Number: 97848
Chromosome: 2
Deletion (size): -3259bp
Research Areas: Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors2. Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation3. Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ4. Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy5. Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity6. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-beta signaling in regulatory T cells7. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness8. The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity9. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression10. Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation11. Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity12. Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis13. A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis14. Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells15. Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection16. Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8(+) T-cell exhaustion17. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8(+) T cell responses18. RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis19. Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice20. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer21. A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice22. A pathological joint-liver axis mediated by matrikine-activated CD4(+) T cells23. The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells24. Reconstituted CD74(+) NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation25. VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation26. TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma27. Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling28. PAC1 constrains type II inflammation through promotion of CGRP signaling in ILC2s29. Crystalline silica-induced recruitment and immuno-imbalance of CD4(+) tissue resident memory T cells promote silicosis progression
Gene Family: DNA transposon derived genesRing finger proteins