C57BL/6JGpt-H11em1Cin(Vil1-icre)/Gpt

Mouse Model: H11-Vil1-iCre
Strain Number: T004714

Knockin (KI)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-H11em1Cin(Vil1-icre)/Gpt
Strain Number: T004714
Official Symbol: Vil1
Strain Strategy: T004714.H11-Vil1-iCre strain info.pdfT004714.H11-Vil1-iCre-ployA Strategy-EN.pdf
Official Full Name: villin 1
Also Known As: Vil
NCBI Number: 22349
MGI Number: 98930
Chromosome: 11
Research Areas: Tool Mice,Cre/Dre
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Genotyping Protocols: T004714.Vil1-iCre Genotyping Protocol(KI).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Fragile Guts Make Fragile Brains: Intestinal Epithelial Nrf2 Deficiency Exacerbates Neurotoxicity Induced by Polystyrene Nanoplastics. ACS Nano (2024)2. Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies. Signal Transduct Target Ther (2024)3. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease. Cell Host Microbe (2024)4. Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production. J Adv Res (2025)5. Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation. Gut Microbes (2025)6. TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity. Journal of experimental & clinical cancer research (2025)
Gene Family: Gelsolin/villins

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.