C57BL/6JGpt-Lyz2^em1Cin(iCre)/Gpt

Lyz2-icre|Strain NO.T003822

Knockin (KI)

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt-Lyz2^em1Cin(iCre)/Gpt
Strain Number:	T003822
Official Symbol:	Lyz2,iCre
Strain Strategy:	T003822.Lyz2-iCre strain info.pdf
Official Full Name:	lysozyme 2
Also Known As:	AI326280,Lys,Lysm,Lyzf2,Lyzs,Lzm,Lzm-s1,Lzp
NCBI Number:	17105
MGI Number:	96897
Chromosome:	10
Research Areas:	Tool Mice,Cre/Dre
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Knockin (KI)
Genotyping Protocols:	T003822.Lyz2-iCre Genotyping Protocol(KI).pdf
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury 2. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses 3. Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2‐Dependent Way 4. Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis 5. NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling 6. NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation 7. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses 8. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism 9. Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization 10. Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis 11. Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption 12. ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis 13. Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice 14. Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics 15. Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation 16. A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression 17. Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice 18. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease 19. Macrophage ATG16L1 promotes liver regeneration after partial hepatectomy 20. Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction 21. Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses 22. METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway