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C57BL/6JGpt-Lyz2em1Cin(iCre)/Gpt

Lyz2-icre|Strain NO.T003822

Knockin (KI)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Lyz2em1Cin(iCre)/Gpt
Strain Number: T003822
Official Symbol: Lyz2,iCre
Strain Strategy: T003822.Lyz2-iCre strain info.pdf
Official Full Name: lysozyme 2
Also Known As: AI326280,Lys,Lysm,Lyzf2,Lyzs,Lzm,Lzm-s1,Lzp
NCBI Number: 17105
MGI Number: 96897
Chromosome: 10
Research Areas: Tool Mice,Cre/Dre
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Genotyping Protocols: T003822.Lyz2-iCre Genotyping Protocol(KI).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury2. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses3. Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2‐Dependent Way4. Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis5. NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling6. NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation7. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses8. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism9. Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization10. Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis11. Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption12. ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis13. Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice14. Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics15. Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation