C57BL/6JGpt-Lyz2^em1Cin(iCre)/Gpt

Lyz2-icre|Strain NO.T003822

Knockin (KI)

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt-Lyz2^em1Cin(iCre)/Gpt
Strain Number:	T003822
Official Symbol:	Lyz2,iCre
Strain Strategy:	T003822.Lyz2-iCre strain info.pdf
Official Full Name:	lysozyme 2
Also Known As:	AI326280,Lys,Lysm,Lyzf2,Lyzs,Lzm,Lzm-s1,Lzp
NCBI Number:	17105
MGI Number:	96897
Chromosome:	10
Research Areas:	Tool Mice,Cre/Dre
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Knockin (KI)
Genotyping Protocols:	T003822.Lyz2-iCre Genotyping Protocol(KI).pdf
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury. International Journal of Biological Sciences (2022)2. Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses. Molecular Cell (2022)3. Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2‐Dependent Way. Journal of Bone and Mineral Research (2021)4. Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis. Journal of Inflammation Research (2021)5. NLRP3 protects mice from radiation-induced colon and skin damage via attenuating cGAS-STING signaling. Toxicology and Applied Pharmacology (2021)6. NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation. Cell proliferation (2021)7. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses. EMBO Mol Med (2023)8. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism. Nature Communications (2023)9. Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization. Genes & Diseases (2024)10. Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis. Redox Biol (2024)11. Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption. Nat Commun (2024)12. ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis. Nat Commun (2024)13. Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice. Commun Biol (2024)14. Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics. eBioMedicine (2024)15. Macrophage NRF1 promotes mitochondrial protein turnover via the ubiquitin proteasome system to limit mitochondrial stress and inflammation. Cell Reports (2024)16. A RANKL-UCHL1-sCD13 negative feedback loop limits osteoclastogenesis in subchondral bone to prevent osteoarthritis progression. Nat Commun (2024)17. Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice. Nat Commun (2022)18. Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn's disease. Cell Host Microbe (2024)19. Macrophage ATG16L1 promotes liver regeneration after partial hepatectomy. JHEP Reports (2025)20. Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction. Cell communication and signaling : CCS (2025)21. Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses. Cell research (2025)22. METTL3 Potentiates M2 Macrophage‐Driven MMT to Aggravate Renal Allograft Fibrosis via the TGF‐β1/Smad3 Pathway. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)23. Metabolomics unveils the role of pipecolic acid in regulating monocytes/macrophages-endothelial cells crosstalk to modulate choroidal neovascularization. Experimental eye research (2025)24. The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation. Cell death and differentiation (2025)25. Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. Cell metabolism (2025)26. E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis. Nat Commun (2025)27. GPNMB disrupts SNARE complex assembly to maintain bacterial proliferation within macrophages. Cell Mol Immunol (2025)28. Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment. Nat Commun (2025)29. Metabolic remodelling produces fumarate via the aspartate-argininosuccinate shunt in macrophages as an antiviral defence. Nat Microbiol (2025)30. Myeloid deficiency of Z-DNA binding protein 1 restricts septic cardiomyopathy via promoting macrophage polarisation towards the M2-subtype. Clin Transl Med (2025)31. Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis. Adv Sci (Weinh) (2025)32. Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups. Cancer Cell (2025)33. Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway. Adv Sci (Weinh) (2025)34. Geranylgeranyl diphosphate synthase deficiency impairs efferocytosis and resolution of acute lung injury. Respiratory research (2025)35. NRF1 coordinates mitochondrial adaptations to dampen intracellular ROS and inflammatory responses during ischemia reperfusion. Cell death discovery (2025)36. Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment. Signal transduction and targeted therapy (2025)37. The anti-atherosclerosis effect and molecular mechanism of AMPKα1 by polarizing monocytes to an M2 phenotype via cell-intrinsic lysosomal lipolysis. Cardiovasc Pathol (2025)38. Targeting notch1 with berbamine alleviates the inflammatory responses of macrophages in sepsis. International immunopharmacology (2025)39. Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma. Science advances (2025)