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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22kitem1Cin(V831M)/Gpt

Mouse Model: NCG-X
Strain Number: T003802

Point mutation (PM)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22kitem1Cin(V831M)/Gpt
Strain Number: T003802
Official Symbol: Kit
Strain Strategy: T003802.NCG-X strain info.pdf
Official Full Name: KIT proto-oncogene receptor tyrosine kinase
Also Known As: Bs,CD117,Fdc,Gsfsco1,Gsfsco5,Gsfsow3,SCO1,SCO5,SOW3,Ssm,Tr-kit,W,c-KIT
NCBI Number: 16590
MGI Number: 96677
Chromosome: 5
Research Areas: Humanized model,Humanization of the immune system,Immunodeficiency
Strain Background: [N000235] NOD/ShiLtJGpt
Modification Type: Point mutation (PM)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia. The American Journal of Human Genetics (2021)2. Hypoxia drives hematopoiesis with the enhancement of T lineage through eliciting arterial specification of hematopoietic endothelial progenitors from hESC. Stem Cell Res Ther (2022)3. Efficient and in situ correction of hemoglobin Constant Spring mutation by prime editing in human hematopoietic cells. Molecular Therapy Nucleic Acids (2024)4. NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma. Cancer Immunol Immunother (2024)5. A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression. Exp Hematol Oncol (2025)6. Molecular characterization of human HSPCs with different cell fates in vivo using single‐cell transcriptome analysis and lentiviral barcoding technology. Clin Transl Med (2024)7. Therapeutic gene correction of HBB frameshift CD41-42 (-TCTT) deletion in human hematopoietic stem cells. Advanced biotechnology (2025)8. Decoding the ontogeny of myeloid lineage diversity by cross-species and developmental analyses of hematopoietic progenitor atlases. Cell Rep (2025)9. Therapeutic adenine base editing of human hematopoietic stem cells. Nat Commun (2023)10. Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Science Advances (2022)11. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol (2023)
Gene Family: CD moleculesImmunoglobulin like domain containingReceptor tyrosine kinases

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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