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C57BL/6JGpt-H11em1Cin(Tek-iCre)/Gpt

Mouse Model: Tek-iCre
Strain Number: T003764

Knockin (KI)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-H11em1Cin(Tek-iCre)/Gpt
Strain Number: T003764
Official Symbol: Tek,iCre
Strain Strategy: T003764.Tek-iCre strain info.pdf
Official Full Name: TEK receptor tyrosine kinase
Also Known As: AA517024,Cd202b,Hyk,STK1,Tie-2,Tie2
NCBI Number: 21687
MGI Number: 98664
Chromosome: 11
Research Areas: Tool Mice,Cre/Dre
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Genotyping Protocols: T003764.H11-Tek-Cre Genotyping Protocol(KI).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Endothelial Transient Receptor Potential Canonical Channel Regulates Angiogenesis and Promotes Recovery After Myocardial Infarction. Journal of the American Heart Association (2022)2. Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification. European heart journal (2022)3. NeuroD1 Regulated Endothelial Gene Expression to Modulate Transduction of AAV-PHP.eB and Recovery Progress after Ischemic Stroke. Aging and Disease (2023)4. cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation. Science Immunology (2024)5. PKM2‐Driven Lactate Overproduction Triggers Endothelial‐To‐Mesenchymal Transition in Ischemic Flap via Mediating TWIST1 Lactylation. Adv Sci (Weinh) (2024)6. GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health. Elife (2024)7. Targeted FTO Knockout in Endothelial Cells Boosts Adhesion and Lowers Inflammatory Infiltration to Alleviate Pulmonary Arterial Hypertension. Biochemical and biophysical research communications (2025)8. Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells. Nat Commun (2025)9. Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells. Cell Mol Life Sci (2025)
Gene Family: CD moleculesFibronectin type III domain containingImmunoglobulin like domain containingReceptor tyrosine kinases

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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