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C57BL/6JGpt-Alkbh5em2Cd6815in34/Gpt

Alkbh5-KO|Strain NO.T003676

Knockout (KO)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Alkbh5em2Cd6815in34/Gpt
Strain Number: T003676
Official Symbol: Alkbh5
Strain Strategy: T003676.Alkbh5 Cas9-KO Strategy-EN.pdf
Official Full Name: alkB homolog 5, RNA demethylase
Also Known As: AW050020,AW215868,Abh5,E130207K11,Ofoxd
NCBI Number: 268420
MGI Number: 2144489
Chromosome: 11
Deletion (size): -6815bp+34bp
Research Areas: Developmental Biology,cell differentiation,Physiological system,reproductive system,endocrine/exocrine glands,Cell biology,cellular,Cell localization,Golgi apparatus,cell nucleus,Molecular biology,DNA methylation,oxidordeuctase
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T003676.Alkbh5 Genotyping Protocol(KO).pdf
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A2. Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment3. m(6)A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal34. ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N (6)-methyladenosine methylation5. CEACAM6 facilitates gastric cancer progression through upregulating SLC27A26. Identification of Cuproptosis-Related Genes for Molecular Subtyping: Predicting Prognostic and Therapeutic Response in Glioma
Gene Family: Alkylation repair homologs