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C57BL/6JGpt-Alkbh5em2Cd6815in34/Gpt

Mouse Model: Alkbh5-KO
Strain Number: T003676

Knockout (KO)

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Alkbh5em2Cd6815in34/Gpt
Strain Number: T003676
Official Symbol: Alkbh5
Strain Strategy: T003676.Alkbh5 Cas9-KO Strategy-EN.pdf
Official Full Name: alkB homolog 5, RNA demethylase
Also Known As: AW050020,AW215868,Abh5,E130207K11,Ofoxd
NCBI Number: 268420
MGI Number: 2144489
Chromosome: 11
Deletion (size): -6815bp+34bp
Research Areas: Developmental Biology,cell differentiation,Physiological system,reproductive system,endocrine/exocrine glands,Cell biology,cellular,Cell localization,Golgi apparatus,cell nucleus,Molecular biology,DNA methylation,oxidordeuctase
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Genotyping Protocols: T003676.Alkbh5 Genotyping Protocol(KO).pdf
Inventory Status: Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A. Clinical and translational medicine (2021)2. Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment. Nature Communications (2023)3. m(6)A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal3. iScience (2023)4. ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N (6)-methyladenosine methylation. Nat Commun (2023)5. ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m6A-dependent manner after myocardial infarction. Biochemical and Biophysical Research Communications (2024)6. ALKBH5 insufficiency protects against ferroptosis-driven cisplatin-induced renal cytotoxicity. Cell Biol Toxicol (2024)
Gene Family: Alkylation repair homologs

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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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