C57BL/6JGpt-Trem2em1Cd3332in1/Gpt
Trem2-KO|Strain NO.T003346
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Trem2em1Cd3332in1/Gpt |
| Strain Number: | T003346 |
| Official Symbol: | Trem2 |
| Strain Strategy: | T003346.Trem2 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | triggering receptor expressed on myeloid cells 2 |
| Also Known As: | TREM-2,Trem2a,Trem2b,Trem2c |
| NCBI Number: | 83433 |
| MGI Number: | 1913150 |
| Chromosome: | 17 |
| Deletion (size): | -3332bp+1bp |
| Research Areas: | Metabolic research,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,immune system,nervous system,Physiological system,cardiovascular system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein,Disease Models,Neurodegenerative diseases,Huntington's disease |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T003346.Trem2 Genotyping Protocol(KO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum2. TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARgamma and CD363. Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages4. Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer |
| Gene Family: | V-set domain containing |