C57BL/6JGpt-Trem2em1Cd3332in1/Gpt
Mouse Model: Trem2-KO
Strain Number: T003346
Knockout (KO)
- Product Type:
- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Trem2em1Cd3332in1/Gpt |
| Strain Number: | T003346 |
| Official Symbol: | Trem2 |
| Strain Strategy: | T003346.Trem2 Cas9-KO Strategy-EN.pdfT003346.Trem2-KO strain info.pdf |
| Official Full Name: | triggering receptor expressed on myeloid cells 2 |
| Also Known As: | TREM-2,Trem2a,Trem2b,Trem2c |
| NCBI Number: | 83433 |
| MGI Number: | 1913150 |
| Chromosome: | 17 |
| Deletion (size): | -3332bp+1bp |
| Research Areas: | Metabolic research,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,immune system,nervous system,Physiological system,cardiovascular system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein,Disease Models,Neurodegenerative diseases,Huntington's disease |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T003346.Trem2 Genotyping Protocol(KO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum. J Cell Mol Med (2023)2. TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARgamma and CD36. Cell Death Dis (2024)3. Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages. PLOS Pathogens (2024)4. Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer. J Exp Clin Cancer Res (2024)5. The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning. Front Immunol (2024) |
| Gene Family: | V-set domain containing |
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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.