C57BL/6JGpt-Cgasem2Cd1012/Gpt
Mouse Model: Cgas-KO
Strain Number: T003215
Knockout (KO)
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- Quantity: - +
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Cgasem2Cd1012/Gpt |
| Strain Number: | T003215 |
| Official Symbol: | Cgas |
| Strain Strategy: | T003215.Cgas Cas9-KO Strategy-EN.pdf |
| Official Full Name: | cyclic GMP-AMP synthase |
| Also Known As: | E330016A19Rik,Mb21d1 |
| NCBI Number: | 214763 |
| MGI Number: | 2442261 |
| Chromosome: | 9 |
| Deletion (size): | -1012bp |
| Research Areas: | Metabolic research,homeostasis/metabolism,Developmental Biology,mortality/aging,immune system,nervous system,behavior/neurological,Physiological system,hematopoietic system,Cell biology,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA binding protein,Lipid binding protein,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T003215.Cgas Genotyping Protocol(KO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway. Nat Biomed Eng (2023)2. Degradation of PARP1 by MARCHF3 in tumor cells triggers cCAS-STING activation in dendritic cells to regulate antitumor immunity in hepatocellular …. J Immunother Cancer (2024) |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.