C57BL/6JGpt-Apoe^em1Cd82/Gpt

Apoe-KO|Strain NO.T001458

Knockout (KO)

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt-Apoe^em1Cd82/Gpt
Strain Number:	T001458
Official Symbol:	Apoe
Strain Strategy:	T001458.Apoe-KO strain info.pdf
Official Full Name:	apolipoprotein E
Also Known As:	AI255918,Apo-E
NCBI Number:	11816
MGI Number:	88057
Chromosome:	7
Deletion (size):	-82bp
Research Areas:	Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Knockout (KO)
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Nicotine modulates CTSS (cathepsin S) synthesis and secretion through regulating the autophagy-lysosomal machinery in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology (2020)2. LncRNA NORAD promotes vascular endothelial cell injury and atherosclerosis through suppressing VEGF gene transcription via enhancing H3K9 deacetylation by recruiting HDAC6. Frontiers in Cell and Developmental Biology (2021)3. Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway. Antioxidants (2021)4. Targeting macrophage liver X receptors by hydrogel‐encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis. British Journal of Pharmacology (2021)5. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biology (2021)6. BTK Promotes Atherosclerosis by Regulating Oxidative Stress, Mitochondrial Injury, and ER Stress of Macrophages. Oxidative Medicine and Cellular Longevity (2021)7. ZBTB20 Positively Regulates Oxidative Stress, Mitochondrial Fission, and Inflammatory Responses of ox-LDL-Induced Macrophages in Atherosclerosis. Oxidative medicine and cellular longevity (2021)8. circDENND1B Participates in the Antiatherosclerotic Effect of IL-1β Monoclonal Antibody in Mouse by Promoting Cholesterol Efflux via miR-17-5p/Abca1 Axis. Frontiers in cell and developmental biology (2021)9. ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway. Theranostics (2021)10. Activated invariant natural killer T cells infiltrate aortic tissue as key participants in abdominal aortic aneurysm pathology. Immunology (2021)11. Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice. Phytomedicine (2022)12. Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production. Cellular Signalling (2022)13. Dual-responsive targeted atherosclerosis therapy through a multi-effective nanoplatform with anti-inflammatory, lipid-regulating and autophagy. Chemical Engineering Journal (2022)14. JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis. J Hematol Oncol (2022)15. Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect. J Nanobiotechnology (2022)16. Natural Cell Patches: Melanin Nanoparticles for MR Imaging‐Guided Antiatherosclerosis Therapy via Attenuating Macrophage Pyroptosis. Advanced Functional Materials (2023)17. Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses. EMBO Mol Med (2023)18. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy. nature neuroscience (2023)19. Plaque Macrophage‐Targeting Nanosystems with Cooperative Co‐Regulation of ROS and TRAF6 for Stabilization of Atherosclerotic Plaques. Advanced Functional Materials (2023)20. Multi-omics reveals aspirin eugenol ester alleviates neurological disease. Biomed Pharmacother (2023)21. Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques. Journal of the American Chemical Society (2023)22. Sulfated glucuronomannan hexamer inhibits lipid accumulation and ameliorates atherosclerosis in apolipoprotein E-deficient mice. Journal of Functional Foods (2023)23. Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis. Sci Adv (2023)24. An elastase-inhibiting, plaque-targeting and neutrophil-hitchhiking liposome against atherosclerosis. Acta Biomater (2023)25. Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn. Biol Direct (2023)26. Transcriptome analysis reveals therapeutic potential of NAMPT in protecting against abdominal aortic aneurysm in human and mouse. Bioact Mater (2024)27. lncRNA JPX-Enriched Chromatin Microenvironment Mediates Vascular Smooth Muscle Cell Senescence and Promotes Atherosclerosis. Arterioscler Thromb Vasc Biol (2024)28. S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype. Front Cell Dev Biol (2023)29. Medium-Dose Formoterol Attenuated Abdominal Aortic Aneurysm Induced by EPO via beta2AR/cAMP/SIRT1 Pathway. Advanced Science (2024)30. Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway. Journal of Traditional and Complementary Medicine (2024)31. Key chromatin regulator-related genes associated with the risk of coronary artery disease regulate the expression of HCFC1, RNF8, TNP1 and SET. Heliyon (2024)32. Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE (-/-) mice. Biochem Pharmacol (2024)33. FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque. J Inflamm Res (2024)34. Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling. Nat Commun (2024)35. ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT. Acta Pharmaceutica Sinica B (2024)36. LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis. CIRCULATION RESEARCH (2024)37. Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy. Cell Biol Toxicol (2024)38. Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation. Journal of Cellular and Molecular Medicine (2024)39. Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation. International Journal of Medical Sciences (2024)40. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Cell Rep (2024)41. Limosilactobacillus fermentum TY-S11 ameliorates hypercholesterolemia via promoting cholesterol excretion and regulating gut microbiota in high-cholesterol diet-fed apolipoprotein E-deficient mice. Heliyon (2024)42. Reparative effects after low-dose radiation exposure: Inhibition of atherosclerosis by reducing NETs release. Sci Total Environ (2024)43. Radiation-Induced Endothelial Ferroptosis Accelerates Atherosclerosis via the DDHD2-Mediated Nrf2/GPX4 Pathway. Biomolecules (2024)44. Increased Expression of Mevalonate Pathway-Related Enzymes in Angiotensin II-Induced Abdominal Aortic Aneurysms. International Heart Journal (2024)45. The metabolite 2-Methylbutyrylcarnitine does not Promote Atherosclerosis in Apolipoprotein E-Deficient Mice. BIO Integration (2024)46. Mechanism of Bile Acid in Regulating Platelet Function and Thrombotic Diseases. Advanced Science (2024)47. Trimethylamine N-oxide promotes PERK-mediated endothelial-mesenchymal transition and apoptosis thereby aggravates atherosclerosis. International Immunopharmacology (2024)48. MiRNA-132/212 encapsulated by adipose tissue-derived exosomes worsen atherosclerosis progression. Cardiovascular Diabetology (2024)49. SGK1 contributes to ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathway. Journal of Molecular and Cellular Cardiology (2024)50. Palmatine protects against atherosclerosis by gut microbiota and phenylalanine metabolism. Pharmacological Research (2024)51. Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1. Journal of Biomedical Science (2024)52. SIRT1 mediates the inflammatory response of macrophages and regulates the TIMP3/ADAM17 pathway in atherosclerosis. Experimental Cell Research (2024)53. Targeting the smooth muscle cell Keap1-Nrf2-GSDMD-pyroptosis axis by cryptotanshinone prevents abdominal aortic aneurysm formation. Theranostics (2024)54. Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation. Cell Death Dis (2024)55. Role and mechanism of Actein on condylar bone metabolism in APOE deletion-induced osteoporotic mice. Bone (2024)56. Tanyu Tongzhi formula attenuates atherosclerotic plaque vulnerability by inhibiting CD40+ monocyte differentiation. Tradit Med Res (2024)57. Nox1/PAK1 is required for angiotensin II-induced vascular inflammation and abdominal aortic aneurysm formation. Redox Biol (2024)58. Design of a deuterated TSPO tracer and its application in glioma and atherosclerotic imaging. New Journal of Chemistry (2024)59. Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 …. J Neuroinflammation (2024)60. Morin, a matrix metalloproteinase 9 inhibitor, attenuates endothelial-to-mesenchymal transition in atherosclerosis by downregulating Notch-1 signaling. J Integr Med (2024)61. Testosterone deficiency aggravates diet-induced non-alcoholic fatty liver disease by inducing hepatocyte ferroptosis via targeting BMAL1 in mice. Int Immunopharmacol (2024)62. Dual-mode-driven nanomotors targeting inflammatory macrophages for the MRI and synergistic treatment of atherosclerosis. Journal of nanobiotechnology (2025)63. Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway. Cardiovascular diabetology (2025)64. Cellular Senescence Genes as Cutting‐Edge Signatures for Abdominal Aortic Aneurysm Diagnosis: Potential for Innovative Therapeutic Interventions. Journal of cellular and molecular medicine (2025)65. Inhibition of bone morphogenetic protein 4 alleviates angiotensin II-induced abdominal aortic aneurysm by reducing inflammation and endothelial-mesenchymal transition. Atherosclerosis (2025)66. Cellular crosstalk in organotypic vasculature: mechanisms of diabetic cardiorenal complications and SGLT2i responses. Cardiovascular diabetology (2025)67. Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. Cell metabolism (2025)68. Ultrabright difuranfluoreno-dithiophen polymers for enhanced afterglow imaging of atherosclerotic plaques. Sci Adv (2025)69. Myricetin alleviates high-fat diet-induced atherosclerosis in ApoE-/- mice by regulating bile acid metabolism involved in gut microbiota remodeling. Food Funct (2025)70. Shexiang Baoxin Pill alleviates atherosclerosis by inhibiting macrophage-mediated inflammation via suppressing KMT5A mediated Irf7 transcription. J Ethnopharmacol (2025)71. Macrophage WEE1 Directly Binds to and Phosphorylates NF-κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis. Adv Sci (Weinh) (2025)72. A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY. Theranostics (2025)73. AMBP protects against aortic valve calcification by inhibiting ERK1/2 and JNK pathways mediated by FHL3. Theranostics (2025)74. Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model. Scientific reports (2025)75. Identification of hub biomarkers in coronary artery disease patients using machine learning and bioinformatic analyses. Scientific reports (2025)76. The anti-atherosclerosis effect and molecular mechanism of AMPKα1 by polarizing monocytes to an M2 phenotype via cell-intrinsic lysosomal lipolysis. Cardiovasc Pathol (2025)77. Lysosomal zinc nanomodulation blocks macrophage pyroptosis for counteracting atherosclerosis progression. Science advances (2025)78. Dehydrocostus lactone attenuates atherogenesis by promoting cholesterol efflux and inhibiting inflammation via TLR2/PPAR-γ/NF-κB signaling pathway. Mol Med (2025)79. EP300-mediated H3K18la regulation of METTL3 promotes macrophage ferroptosis and atherosclerosis through the m6A modification of SLC7A11. Biochimica et biophysica acta. General subjects (2025)80. sFRP5 ameliorates atherosclerosis by suppressing the JNK/TLR9 pathway in macrophages. Transl Res (2025)81. Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC. Molecular cancer (2025)82. Lactate-Activated GPR132-Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes. Adv Sci (Weinh) (2025)83. Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway. Adv Sci (Weinh) (2025)
Gene Family:	Apolipoproteins