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C57BL/6JGpt-Lepem1Cd25/Gpt

B6-ob|Strain NO.T001461

Knockout (KO),Unknown or confidential

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Lepem1Cd25/Gpt
Strain Number: T001461
Official Symbol: Lep,ob
Strain Strategy: T001461.B6-ob strain info.pdf
Official Full Name: leptin
Also Known As: ob,obese
NCBI Number: 16846
MGI Number: 104663
Chromosome: 6
Research Areas: Disease Models,Metabolic Disease,Obesity model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO),Unknown or confidential
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity2. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo3. Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms4. Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model5. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging6. Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner7. Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer8. MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake9. Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer10. Anti-aging mechanism of different age donor-matched adipose-derived stem cells11. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction12. Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)13. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes14. Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate15. Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption16. USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK117. Amino acid is a major carbon source for hepatic lipogenesis18. Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis19. The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity20. Lack of adipocyte FAM20C improves whole body glucose homeostasis
Gene Family: Neuropeptides