B6-ob|Strain NO.T001461

Knockout (KO),Unknown or confidential

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Strain Name: C57BL/6JGpt-Lepem1Cd25/Gpt
Strain Number: T001461
Official Symbol: Lep,ob
Strain Strategy: T001461.Lep Cas9-KO Strategy-EN.pdfT001461.B6-ob strain Info.pdf
Official Full Name: leptin
Also Known As: ob,obese
NCBI Number: 16846
MGI Number: 104663
Chromosome: 6
Research Areas: Disease Models,Metabolic Disease,Obesity model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO),Unknown or confidential
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity2. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo3. Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms4. Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model5. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging6. Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner7. Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer8. MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake9. Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer10. Anti-aging mechanism of different age donor-matched adipose-derived stem cells11. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction12. Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)13. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes14. Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate
Gene Family: Neuropeptides