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C57BL/6JGpt-Lepem1Cd25/Gpt

B6-ob|Strain NO.T001461

Knockout (KO),Unknown or confidential

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Lepem1Cd25/Gpt
Strain Number: T001461
Official Symbol: ob
Strain Strategy: T001461.B6-ob strain info.pdf
Official Full Name: leptin
Also Known As: ob,obese
NCBI Number: 16846
MGI Number: 104663
Chromosome: 6
Research Areas: Disease Models,Metabolic Disease,Obesity model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO),Unknown or confidential
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell Metabolism (2021)2. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Advanced Science (2020)3. Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms. Food & function (2020)4. Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model. Life Sciences (2021)5. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry (2021)6. Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner. The FASEB Journal (2021)7. Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer. Cancer Sci (2022)8. MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake. Nat Commun (2022)9. Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer. Adv Sci (Weinh) (2022)10. Anti-aging mechanism of different age donor-matched adipose-derived stem cells. Stem Cell Res Ther (2023)11. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction. Mol Metab (2024)12. Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor). Signal Transduct Target Ther (2024)13. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes. Heliyon (2024)14. Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate. ACS Nano (2024)15. Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption. Nat Metab (2024)16. USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1. J Transl Med (2024)17. Amino acid is a major carbon source for hepatic lipogenesis. Cell Metab (2024)18. Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis. NPJ Regen Med (2024)19. The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity. Clin Transl Med (2024)20. Lack of adipocyte FAM20C improves whole body glucose homeostasis. Physiol Rep (2024)21. Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice. Journal of biomedical science (2025)
Gene Family: Neuropeptides