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C57BL/6JGpt-Lepem1Cd25/Gpt

Mouse Model: B6-ob
Strain Number: T001461

Knockout (KO),Unknown or confidential

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Lepem1Cd25/Gpt
Strain Number: T001461
Official Symbol: Lep
Strain Strategy: T001461.B6-ob strain info.pdf
Official Full Name: leptin
Also Known As: ob,obese
NCBI Number: 16846
MGI Number: 104663
Chromosome: 6
Research Areas: Disease Models,Metabolic Disease,Obesity model
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO),Unknown or confidential
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity. Cell Metabolism (2021)2. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo. Advanced Science (2020)3. Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms. Food & function (2020)4. Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model. Life Sciences (2021)5. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry (2021)6. Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner. The FASEB Journal (2021)7. Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer. Cancer Sci (2022)8. MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake. Nat Commun (2022)9. Anti-aging mechanism of different age donor-matched adipose-derived stem cells. Stem Cell Res Ther (2023)10. Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction. Mol Metab (2024)11. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes. Heliyon (2024)12. USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1. J Transl Med (2024)13. Macrophage-derived extracellular vesicles transfer mitochondria to adipocytes and promote adipocyte–myofibroblast transition in epidural fibrosis. NPJ Regen Med (2024)14. The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity. Clin Transl Med (2024)15. Lack of adipocyte FAM20C improves whole body glucose homeostasis. Physiol Rep (2024)16. Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice. Journal of biomedical science (2025)17. A Novel Recombinant Human FGF21 Analog with High Glycosylation Has a Prolonged Half-Life and Affects Glycemic and Body Weight Control. Int J Mol Sci (2025)18. SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2. Cell Mol Life Sci (2025)19. Mib2 Regulates Lipid Metabolism in Heart Failure With Preserved Ejection Fraction via the Runx2-Hmgcs2 Axis. J Cell Mol Med (2025)20. Metagenomic and metabolomic analyses show correlations between intestinal microbiome diversity and microbiome metabolites in ob/ob and ApoE(-/-) mice. Front Nutr (2022)21. Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate. ACS Nano (2024)22. Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer. Adv Sci (Weinh) (2022)23. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Mil Med Res (2025)24. Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption. Nat Metab (2024)25. Amino acid is a major carbon source for hepatic lipogenesis. Cell Metab (2024)26. Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor). Signal Transduct Target Ther (2024)
Gene Family: Neuropeptides

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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