APC-min|Strain NO.T001457

Point mutation (PM)

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Strain Name: C57BL/6JGpt-Apcem1Cin(Min)/Gpt
Strain Number: T001457
Official Symbol: Apc
Strain Strategy: T001457.Apc-min strain info.pdf
Official Full Name: APC, WNT signaling pathway regulator
Also Known As: AI047805,AU020952,AW124434,CC1,Min,mAPC
NCBI Number: 11789
MGI Number: 88039
Chromosome: 18
Research Areas: Disease Models,Tumor model,Spontaneous tumor
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Point mutation (PM)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors2. Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment3. Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK4. Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway5. The protection of crocin against ulcerative colitis and colorectal cancer via suppression of NF-κB-mediated inflammation6. Effect of pristimerin on apoptosis through activation of ROS/endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer7. ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function8. Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function9. IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling10. p53 promotes peroxisomal fatty acid beta-oxidation to repress purine biosynthesis and mediate tumor suppression11. Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism12. A novel antidiuretic hormone governs tumour-induced renal dysfunction13. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer14. A Free Amino Acid Diet Alleviates Colorectal Tumorigenesis through Modulating Gut Microbiota and Metabolites
Gene Family: Armadillo repeat containingProtein phosphatase 1 regulatory subunits