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C57BL/6JGpt-Apcem1Cin(Min)/Gpt

APC-min|Strain NO.T001457

Knockin (KI)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Apcem1Cin(Min)/Gpt
Strain Number: T001457
Official Symbol: Apc
Strain Strategy: T001457.Apc-min strain info.pdf
Official Full Name: APC, WNT signaling pathway regulator
Also Known As: AI047805,AU020952,AW124434,CC1,Min,mAPC
NCBI Number: 11789
MGI Number: 88039
Chromosome: 18
Research Areas: Disease Models,Tumor model,Spontaneous tumor
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors. Nature communications (2020)2. Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment. Biomedicine & Pharmacotherapy (2020)3. Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK. Phytomedicine (2020)4. Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway. Food Science and Human Wellness (2021)5. The protection of crocin against ulcerative colitis and colorectal cancer via suppression of NF-κB-mediated inflammation. Frontiers in pharmacology (2021)6. Effect of pristimerin on apoptosis through activation of ROS/endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer. Phytomedicine (2021)7. ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function.. Aging-US (2022)8. Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function. Front Pharmacol (2022)9. IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2022)10. Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism. Food and Agricultural Immunology (2023)11. A Free Amino Acid Diet Alleviates Colorectal Tumorigenesis through Modulating Gut Microbiota and Metabolites. Nutrients (2024)12. Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APC(min/+) Mice. Toxins (2024)13. Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice. iScience (2024)14. Astragaloside IV Ameliorates Colonic Adenomatous Polyps Development by Orchestrating Gut Bifidobacterium and Serum Metabolome. American Journal of Chinese Medicine (2024)15. Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum. World Journal of Gastrointestinal Oncology (2024)16. ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity. Neoplasia (2025)17. p53 promotes peroxisomal fatty acid beta-oxidation to repress purine biosynthesis and mediate tumor suppression. Cell Death & Disease (2023)18. BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism. Cell Host Microbe (2024)19. Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy. Nat Commun (2025)20. Caspase-6/Gasdermin C-Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2-Dependent Recruitment of Myeloid-Derived Suppressor Cells. Adv Sci (Weinh) (2025)21. Shen-Bai-Jie-Du decoction suppresses the progression of colorectal adenoma to carcinoma through regulating gut microbiota and short-chain fatty acids. Chin Med (2024)22. Parvimonas micra activates the Ras/ERK/c-Fos pathway by upregulating miR-218-5p to promote colorectal cancer progression. J Exp Clin Cancer Res (2023)23. Solobacterium moorei promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer. International journal of biological sciences (2025)24. A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Rep Med (2024)25. CDKL3 is a targetable regulator of cell cycle progression in cancers. J Clin Invest (2024)26. Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP-Ribosylation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)27. A novel antidiuretic hormone governs tumour-induced renal dysfunction. Nature (2023)
Gene Family: Armadillo repeat containingProtein phosphatase 1 regulatory subunits