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C57BL/6JGpt-Apcem1Cin(Min)/Gpt

Model: APC-min
Strain Number: T001457

Knockin (KI)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Apcem1Cin(Min)/Gpt
Strain Number: T001457
Official Symbol: Apc
Strain Strategy: T001457.Apc-min strain info.pdf
Official Full Name: APC, WNT signaling pathway regulator
Also Known As: AI047805,AU020952,AW124434,CC1,Min,mAPC
NCBI Number: 11789
MGI Number: 88039
Chromosome: 18
Research Areas: Disease Models,Tumor model,Spontaneous tumor
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors. Nature communications (2020)2. Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment. Biomedicine & Pharmacotherapy (2020)3. Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK. Phytomedicine (2020)4. Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway. Food Science and Human Wellness (2021)5. The protection of crocin against ulcerative colitis and colorectal cancer via suppression of NF-κB-mediated inflammation. Frontiers in pharmacology (2021)6. Effect of pristimerin on apoptosis through activation of ROS/endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer. Phytomedicine (2021)7. ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function.. Aging-US (2022)8. Calf Thymus Polypeptide Restrains the Growth of Colorectal Tumor via Regulating the Intestinal Microbiota-Mediated Immune Function. Front Pharmacol (2022)9. IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2022)10. Overdose intake of Neu5Gc triggers colorectal inflammation and alters liver metabolism. Food and Agricultural Immunology (2023)11. A Free Amino Acid Diet Alleviates Colorectal Tumorigenesis through Modulating Gut Microbiota and Metabolites. Nutrients (2024)12. Exposure to Microcystin-LR Promotes Colorectal Cancer Progression by Altering Gut Microbiota and Associated Metabolites in APC(min/+) Mice. Toxins (2024)13. Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice. iScience (2024)14. Astragaloside IV Ameliorates Colonic Adenomatous Polyps Development by Orchestrating Gut Bifidobacterium and Serum Metabolome. American Journal of Chinese Medicine (2024)15. Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum. World Journal of Gastrointestinal Oncology (2024)16. ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity. Neoplasia (2025)17. Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer. Cell Rep Med (2025)18. Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis. Nature communications (2025)19. CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis. Cell reports (2025)20. Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by attenuating the malignancy of cancer stem cells via the gut microbiota-bile acid-FXR axis. Phytomedicine (2025)
Gene Family: Armadillo repeat containingProtein phosphatase 1 regulatory subunits

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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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