Ldlr-KO|Strain NO.T001464

Knockout (KO)

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Strain Name: C57BL/6JGpt-Ldlrem1Cd82/Gpt
Strain Number: T001464
Official Symbol: Ldlr
Strain Strategy: T001464.Ldlr Cas9-KO Strategy-EN.pdfT001464.Ldlr-KO strain info.pdf
Official Full Name: low density lipoprotein receptor
Also Known As: Hlb301
NCBI Number: 16835
MGI Number: 96765
Chromosome: 9
Deletion (size): -82bp
Research Areas: Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice2. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia3. circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression4. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation5. Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages6. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways7. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus8. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion9. A gut-derived hormone regulates cholesterol metabolism
Gene Family: Low density lipoprotein receptorsMicroRNA protein coding host genes