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C57BL/6JGpt-Ldlrem1Cd82/Gpt

Mouse Model: Ldlr-KO
Strain Number: T001464

Knockout (KO)

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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library

With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Ldlrem1Cd82/Gpt
Strain Number: T001464
Official Symbol: Ldlr
Strain Strategy: T001464.LDL-R-KO strain info.pdf
Official Full Name: low density lipoprotein receptor
Also Known As: Hlb301
NCBI Number: 16835
MGI Number: 96765
Chromosome: 9
Deletion (size): -82bp
Research Areas: Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice. Food & Function (2021)2. circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression. Molecular Therapy-Nucleic Acids (2021)3. Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages. Front Pharmacol (2023)4. Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor. Cell Death Dis (2024)5. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice. Journal of Lipid Research (2024)6. BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity. Cell Rep (2025)7. Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatment. BMC cancer (2025)8. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia. The Journal of clinical investigation (2021)9. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation. J Mol Cell Biol (2023)10. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways. Eur Heart J (2023)11. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus. Cell Res (2024)12. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Mil Med Res (2025)13. A gut-derived hormone regulates cholesterol metabolism. Cell (2024)14. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature (2022)
Gene Family: Low density lipoprotein receptorsMicroRNA protein coding host genes

Extend the Value of Your Mouse Models with Integrated Preclinical Services

GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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