Hot Search:

C57BL/6JGpt-Ldlrem1Cd82/Gpt

Ldlr-KO|Strain NO.T001464

Knockout (KO)

  • Product Type:
  • Quantity: - +
  • Sex:
  • Age:
  • Genotype:
BASIC INFORMATION
Strain Name: C57BL/6JGpt-Ldlrem1Cd82/Gpt
Strain Number: T001464
Official Symbol: Ldlr
Strain Strategy: T001464.LDL-R-KO strain info.pdf
Official Full Name: low density lipoprotein receptor
Also Known As: Hlb301
NCBI Number: 16835
MGI Number: 96765
Chromosome: 9
Deletion (size): -82bp
Research Areas: Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice. Food & Function (2021)2. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia. The Journal of clinical investigation (2021)3. circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression. Molecular Therapy-Nucleic Acids (2021)4. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation. J Mol Cell Biol (2023)5. Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages. Front Pharmacol (2023)6. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways. Eur Heart J (2023)7. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus. Cell Res (2024)8. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature (2022)9. A gut-derived hormone regulates cholesterol metabolism. Cell (2024)10. Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor. Cell Death Dis (2024)11. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice. Journal of Lipid Research (2024)12. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Mil Med Res (2025)13. BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity. Cell Rep (2025)
Gene Family: Low density lipoprotein receptorsMicroRNA protein coding host genes