C57BL/6JGpt-Ldlr^em1Cd82/Gpt

Ldlr-KO|Strain NO.T001464

Knockout (KO)

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BASIC INFORMATION

Strain Name:	C57BL/6JGpt-Ldlr^em1Cd82/Gpt
Strain Number:	T001464
Official Symbol:	Ldlr
Strain Strategy:	T001464.Ldlr-KO strain info.pdf T001464.Ldlr-KO Strategy-EN.pdf
Official Full Name:	low density lipoprotein receptor
Also Known As:	Hlb301
NCBI Number:	16835
MGI Number:	96765
Chromosome:	9
Deletion (size):	-82bp
Research Areas:	Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background:	[N000013] C57BL/6JGpt
Modification Type:	Knockout (KO)
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice 2. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia 3. circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression 4. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation 5. Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages 6. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways 7. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus 8. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion 9. A gut-derived hormone regulates cholesterol metabolism 10. Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor 11. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice
Gene Family:	Low density lipoprotein receptors MicroRNA protein coding host genes