Hot Search:

C57BL/6JGpt-Ldlrem1Cd82/Gpt

Ldlr-KO|Strain NO.T001464

Knockout (KO)

  • Product Type:
  • Quantity: - +
  • Sex:
  • Age:
  • Genotype:
BASIC INFORMATION
Strain Name: C57BL/6JGpt-Ldlrem1Cd82/Gpt
Strain Number: T001464
Official Symbol: Ldlr
Strain Strategy: T001464.LDL-R-KO strain info.pdf
Official Full Name: low density lipoprotein receptor
Also Known As: Hlb301
NCBI Number: 16835
MGI Number: 96765
Chromosome: 9
Deletion (size): -82bp
Research Areas: Disease Models,Cardiovascular Disease,Atherosclerosis,Hyperlipidemia
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockout (KO)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice. Food & Function (2021)2. circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression. Molecular Therapy-Nucleic Acids (2021)3. Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages. Front Pharmacol (2023)4. Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor. Cell Death Dis (2024)5. siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice. Journal of Lipid Research (2024)6. BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity. Cell Rep (2025)7. Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatment. BMC cancer (2025)8. Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia. The Journal of clinical investigation (2021)9. Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation. J Mol Cell Biol (2023)10. Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways. Eur Heart J (2023)11. LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus. Cell Res (2024)12. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Mil Med Res (2025)13. A gut-derived hormone regulates cholesterol metabolism. Cell (2024)14. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature (2022)
Gene Family: Low density lipoprotein receptorsMicroRNA protein coding host genes