Detail information of PDX-CRC00459
Growth Properties
Fig 1. Growth Properties
Pathology Diagnosis
Tumor size: Left hemicolectomy sample. The size of the lump is 5cm * 3.5cm * 1.3cm. The cancer tissue invaded the periintestinal fibrous adipose tissue, and no clear vascular tumor thrombus was found. Neurological invasion was observed..
Histological type: Ulcerative tubular adenocarcinoma of the colon.
Stage: ⅡA(T3 N0 cM0).
Histological grading: moderately differentiated.
IHC: Tumor cells express MLH1 (+++), MSH2 (+++), PMS2 (+++), and MSH6 (+++).
Gene mutation in WES
Table 1. Gene mutation (Partial)
Gen | Hgvs | Priority |
EGFR | p.R254K | L |
KRAS | p.G12D | H |
ALK | p.K423R; p.K1491R; p.I1461Vc; p.I393V; p.D461E; p.D1529E | L |
TP53 | p.P33R; p.P72R | L |
PTCH1 | p.T1143S; p.T1129S; p.T1044S; p.T1195S; p.T1194S; p.P1315L; p.P1249L; p.P1164L; p.P1314L; p.P1263L | L |
BRCA1 | p.E991G; p.E1038G; p.S1566G; p.S509G; p.S1613G; p.S1634G; p.P871L; p.P824L; p.K1183R; p.K1136R | L |
RET | p.T278N; p.T24N | L |
ERBB2 | p.P1140A; p.P1170A; p.P1155A; p.I640V; p.I655V; p.I625V | L |
ERBB2 | p.P1140A; p.P1170A; p.P1155A; p.I640V; p.I655V; p.I625V | L |