Detail information of PDX-CRC00459

  • Growth Properties

图片2.png

Fig 1.  Growth Properties


  • Pathology Diagnosis

Tumor size: Left hemicolectomy sample. The size of the lump is 5cm * 3.5cm * 1.3cm. The cancer tissue invaded the periintestinal fibrous adipose tissue, and no clear vascular tumor thrombus was found. Neurological invasion was observed..

Histological type: Ulcerative tubular adenocarcinoma of the colon.

Stage: ⅡA(T3 N0 cM0).

Histological grading: moderately differentiated.

IHC: Tumor cells express MLH1 (+++), MSH2 (+++), PMS2 (+++), and MSH6 (+++).


  • Gene mutation in WES

Table 1. Gene mutation  (Partial)

Gen

Hgvs

Priority

EGFR

p.R254K

L

KRAS

p.G12D

H

ALK

p.K423R; p.K1491R; p.I1461Vc; p.I393V; p.D461E; p.D1529E

L

TP53

p.P33R; p.P72R

L

PTCH1

p.T1143S; p.T1129S; p.T1044S; p.T1195S; p.T1194S; p.P1315L; p.P1249L; p.P1164L; p.P1314L; p.P1263L

L

BRCA1

p.E991G; p.E1038G; p.S1566G; p.S509G; p.S1613G; p.S1634G; p.P871L; p.P824L; p.K1183R; p.K1136R

L

RET

p.T278N; p.T24N

L

ERBB2

p.P1140A; p.P1170A; p.P1155A; p.I640V; p.I655V; p.I625V

L

ERBB2

p.P1140A; p.P1170A; p.P1155A; p.I640V; p.I655V; p.I625V

L