Detail information of PDX-BRC00406

  • Growth Properties

图片2.png

Fig 1.  Growth Properties

  • Pathology Diagnosis

Tumor size: 1.8cm×1.5cm×1.2cm.

Histological type: Infiltrating carcinoma（Without capsule, infiltrating adipose tissue can be seen around to form sub foci, and focal nuclear division is slightly active）.

Histological grading: Low grade malignancy.

pTNM staging: T1c.

IHC: (Left breast) Tumor cells ER (-), PR (-), Her-2 (-), Ki67 (hot spot approximately 25%+), CK5/6 (+), P53 (-), Calponin (focal+), P63 (-), SMMHC (focal+), GATA3 (-), S-100 (+), SOX10 (+), CK pan (+), EMA (+), CK14 (focal+), Syn (-).

  • Gene mutation in WES

Table 1. Gene mutation (Partial)

Gene

Hgvs

Priority

ALK

p.K423R; p.K1491R; p.I1461V; p.I393V; p.D461E; p.D1529E

L

PTCH1

p.T1143S; p.T1129S; p.T1044S

L

BRCA1

p.E991G; p.E1038G; p.S1613G; p.S1566G; p.S509G; p.S1634G; p.P871L; p.P824L; p.K1183R; p.K1136R

L

BRCA2

p.N991D; p.V2466A; p.N289H

L

CSF1R


p.H362R

L

ERBB2

p.P1155A; p.P1140A; p.P1170A

L

FLT3

p.T227M

L

FGFR2

p.M186T;  p.M97T

p.M71T; p.G149W; p.G238W; p.G123W

L

H