Detail information of PDX-BRC00257

  • Growth Properties

图片1.png

Fig 1.  Growth Properties

  • Pathology Diagnosis

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Fig 2. Clinical pathological diagnosis (HE-P0)


Tumor size: Maximum diameter of invasive carcinoma under microscope: at least 3.5cm, Other diameters 3.2cm × 2.6cm.

Histological type: Invasive ductal carcinoma, non-specific type.

Histological grading: Level III (poorly differentiated).

Nottingham: Gland formation is 3 points, nuclear grade is 3 points, nuclear division is 3 points, and total score is 9 points.

pTNM staging: T2.

IHC: (Left breast) ER(-), PR(-), Her-2(-), Ki-67(90%+), CK5/6(Individual cells + ), P53(+++).

  • Gene mutation in WES

Table 1. Gene mutation  (Partial)

Gene

Hgvs

Priority

EGFR

p.R468K; p.R476K; p.R521K

L

ALK

p.K423R; p.K1491R; p.I1461V; p.I393V; p.D461E; p.D1529E

L

TP53

p.R210M; p.R249M; p.R90M; p.R117M

H

BRCA1

p.E991G; p.E1038G; p.S1613G); p.S1566G; p.S509G; p.S1634G; p.P871L; p.P824L; p.K1183R;.p.K1136R

L

ERBB2

p.P1155A; p.P1140A; p.P1170A

L

MET

p.I22V; p.I452V; p.I452V; p.I452V

L

FGFR2

p.M186T; p.M97T; p.M71T

L