Detail information of PDX-BRC00257
Growth Properties
Fig 1. Growth Properties
Pathology Diagnosis
Fig 2. Clinical pathological diagnosis (HE-P0)
Tumor size: Maximum diameter of invasive carcinoma under microscope: at least 3.5cm, Other diameters 3.2cm × 2.6cm.
Histological type: Invasive ductal carcinoma, non-specific type.
Histological grading: Level III (poorly differentiated).
Nottingham: Gland formation is 3 points, nuclear grade is 3 points, nuclear division is 3 points, and total score is 9 points.
pTNM staging: T2.
IHC: (Left breast) ER(-), PR(-), Her-2(-), Ki-67(90%+), CK5/6(Individual cells + ), P53(+++).
Gene mutation in WES
Table 1. Gene mutation (Partial)
Gene | Hgvs | Priority |
EGFR | p.R468K; p.R476K; p.R521K | L |
ALK | p.K423R; p.K1491R; p.I1461V; p.I393V; p.D461E; p.D1529E | L |
TP53 | p.R210M; p.R249M; p.R90M; p.R117M | H |
BRCA1 | p.E991G; p.E1038G; p.S1613G); p.S1566G; p.S509G; p.S1634G; p.P871L; p.P824L; p.K1183R;.p.K1136R | L |
ERBB2 | p.P1155A; p.P1140A; p.P1170A | L |
MET | p.I22V; p.I452V; p.I452V; p.I452V | L |
FGFR2 | p.M186T; p.M97T; p.M71T | L |