Detail information of PDX-BLC00424

  • Growth Properties

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  • Pathology Diagnosis

Tumor size: Tumor size 3.5 × 2 × 2 cm, the tumor infiltrates the entire bladder wall to the surrounding adipose tissue.

Histological type: Invasive urothelial carcinoma (high grade).

Histological grading: High grade.

IHC: GATA3(+), CK5/6(+), P63 (+), CK7 (small focal cells +), CK20 (few cells +), Ki-67 (about 60% +).

  • Gene mutation in WES

Table 1. Gene mutation (Partial)

Gene

Hgvs

Priority

EGFR

p.R468K

L

ALK

p.K423R; p.K1491R; p.I1461V; p.I393V; p.D1529E; p.D461E

L

PTCH1

p.P1315L; p.P1249L; p.P1164L; p.P1314L; p.P1263L

L

RET

p.G691S; p.G437S; p.R982C; p.R728C; p.R67H

L

BRCA2

p.N372H; p.V2466A

L

CSF1R

p.G936S
p.H362R

M

L

ERBB2

p.P1155A; p.P1140A; p.P1170A

L

FLT3

p.D7G

L

FGFR3

p.G44S

M

RB1

p.L343V

H

TBCE（HRD)

p.T217M; p.T104M

H